(Q36999042)

English

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells

scientific article published on May 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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object named as

Thomas Kukar

15

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Malú Gámez Tansey

16

object named as

Malú G Tansey

1 reference

Europe PubMed Central

17 August 2017

PMC publication ID

2

object named as

Jianjun Chang

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Europe PubMed Central

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17 August 2017

10

object named as

Jaegwon Chung

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17 August 2017

Robert V Farese

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object named as

Robert V Farese

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17 August 2017

author name string

Xi Chen

1

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17 August 2017

Qiudong Deng

3

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17 August 2017

Jie Xu

4

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17 August 2017

Thi A Nguyen

5

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17 August 2017

Lauren H Martens

6

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17 August 2017

Basar Cenik

7

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17 August 2017

Georgia Taylor

8

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17 August 2017

Kathryn F Hudson

9

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17 August 2017

Kimberley Yu

11

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17 August 2017

Phillip Yu

12

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17 August 2017

Joachim Herz

13

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17 August 2017

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publication date

1 May 2013

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17 August 2017

Journal of Neuroscience

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17 August 2017

33

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17 August 2017

21

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17 August 2017

9202-9213

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Europe PubMed Central

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17 August 2017

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Progranulin regulates neuronal outgrowth independent of sortilin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage

1 reference

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29 September 2017

Regulation of microglia effector functions by tumor necrosis factor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Core features of frontotemporal dementia recapitulated in progranulin knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Potential mechanisms of progranulin-deficient FTLD

1 reference

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29 September 2017

Regulator of G-protein signaling-10 negatively regulates NF-κB in microglia and neuroprotects dopaminergic neurons in hemiparkinsonian rats

1 reference

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29 September 2017

Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Structure, function, and mechanism of progranulin; the brain and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Roles of soluble and membrane TNF and related ligands in mycobacterial infections: effects of selective and non-selective TNF inhibitors during infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

TDP-43 is a developmentally regulated protein essential for early embryonic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Progranulin is expressed within motor neurons and promotes neuronal cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Substrate-targeting gamma-secretase modulators

1 reference

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29 September 2017

The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease

1 reference

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29 September 2017

Synaptic scaling mediated by glial TNF-alpha

1 reference

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29 September 2017

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

1 reference

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29 September 2017

Molecular mechanism of TNF signaling and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Quantitative real-time polymerase chain reaction measurement of regulators of G-protein signaling mRNA levels in mouse tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

1 reference

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29 September 2017

Progranulin is a mediator of the wound response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Biological activities and signaling pathways of the granulin/epithelin precursor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

29 September 2017

Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

27 June 2018

Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

27 June 2018

GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

4 September 2018

Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

4 September 2018

rs5848 variant of progranulin gene is a risk of Alzheimer's disease in the Taiwanese population.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

4 September 2018

Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

4 September 2018

Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

4 September 2018

Synaptic dysfunction in progranulin-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707136

4 December 2018

Identifiers

10.1523/JNEUROSCI.5336-12.2013

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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