(Q37003068)

English

Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection

scientific article published on December 2005

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Kenneth A Jacobson

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Zhan-Guo Gao

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Susanna Tchilibon

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Heng T Duong

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Bhalchandra V Joshi

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Dmitry Sonin

6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Bruce T Liang

7

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

language of work or name

0 references

publication date

1 December 2005

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

48

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

26

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

8103-8107

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Adenosine and brain function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

Role of adenosine A1 and A3 receptors in regulation of cardiomyocyte homeostasis after mitochondrial respiratory chain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

A new synthetic route to (North)-methanocarba nucleosides designed as A3 adenosine receptor agonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

Navigating chemical space for biology and medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

Adenosine receptor agonists: from basic medicinal chemistry to clinical development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

N6-Substituted adenosine derivatives: selectivity, efficacy, and species differences at A3 adenosine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

Overexpression of A(3) adenosine receptors decreases heart rate, preserves energetics, and protects ischemic hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

A novel pharmacological approach to treating cardiac ischemia. Binary conjugates of A1 and A3 adenosine receptor agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

A physiological role of the adenosine A3 receptor: sustained cardioprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

A binding site model and structure-activity relationships for the rat A3 adenosine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

29 September 2017

Adenosine receptor subtypes mediating coronary vasodilation in rat hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

27 June 2018

Distinct cardioprotective effects of adenosine mediated by differential coupling of receptor subtypes to phospholipases C and D.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

27 June 2018

Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

27 June 2018

Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

4 September 2018

Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

4 September 2018

Protein kinase C-delta mediates adenosine A3 receptor-induced delayed cardioprotection in mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

4 September 2018

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

4 September 2018

Adenosine A(3) receptor activation protects the myocardium from reperfusion/reoxygenation injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

4 September 2018

Adenosine-mediated cardioprotection in ischemic-reperfused mouse heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

4 September 2018

Protection of IB-MECA against myocardial stunning in conscious rabbits is not mediated by the A1 adenosine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597460

4 September 2018

Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/16366590

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a role for both the adenosine A1 and A3 receptors in protection of isolated human atrial muscle against simulated ischaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16366590

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM050726B

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

0 references

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