(Q37004418)

17 August 2017

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title

Role of the melatonin system in the control of sleep: therapeutic implications (English)

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Seithikurippu R. Pandi-Perumal

17 August 2017

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object named as

Seithikurippu R Pandi-Perumal

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17 August 2017

author name string

Venkatramanujan Srinivasan

2

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17 August 2017

D Warren Spence

3

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17 August 2017

Daniel P Cardinali

4

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17 August 2017

publication date

1 January 2007

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17 August 2017

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17 August 2017

volume

21

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17 August 2017

issue

12

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17 August 2017

page(s)

995-1018

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https://scigraph.springernature.com/pub.10.2165/00023210-200721120-00004

17 August 2017

exact match

0 references

cites work

Sleep disorders and melatonin rhythms in elderly people

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721120-00004

Regulation of pineal serotonin N-acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721120-00004

The neurobiology of sleep: genetics, cellular physiology and subcortical networks

21 January 2018

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https://api.crossref.org/works/10.2165%2F00023210-200721120-00004

Integration of human sleep-wake regulation and circadian rhythmicity

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721120-00004

Delayed sleep phase syndrome. A chronobiological disorder with sleep-onset insomnia

21 January 2018

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https://api.crossref.org/works/10.2165%2F00023210-200721120-00004

Delayed sleep phase syndrome: a review of its clinical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721120-00004

A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721120-00004

Melatonin for the prevention and treatment of jet lag.

21 January 2018

1 reference

12 December 2020

Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: an open-label pilot study using actigraphy

1 reference

12 December 2020

Melatonin: a major regulator of the circadian rhythm of core temperature in humans

1 reference

12 December 2020

Potential of Melatonin Replacement Therapy in Older Patients with Sleep Disorders

1 reference

12 December 2020

First-night effect of melatonin treatment in patients with chronic schizophrenia.

1 reference

12 December 2020

Toxicology of Melatonin

1 reference

12 December 2020

Familial advanced sleep phase syndrome

1 reference

12 December 2020

Delayed sleep phase syndrome response to melatonin

1 reference

12 December 2020

Melatonin in medically ill patients with insomnia: a double-blind, placebo-controlled study.

1 reference

12 December 2020

Hypothalamic regulation of sleep and circadian rhythms

1 reference

12 December 2020

Thermoregulatory effects of melatonin in relation to sleepiness

1 reference

12 December 2020

Effect of pharmacological daytime doses of melatonin on human mood and performance.

1 reference

12 December 2020

The circadian melatonin and cortisol secretion pattern in permanent night shift workers

1 reference

12 December 2020

The impact of insomnia on cognitive functioning in older adults.

1 reference

12 December 2020

Melatonin analogues as agonists and antagonists in the circadian system and other brain areas.

1 reference

12 December 2020

Basic aspects of melatonin action.

1 reference

12 December 2020

Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia

1 reference

12 December 2020

Neural control of the pineal gland

1 reference

12 December 2020

The Pineal As A Neuroendocrine Transducer

1 reference

12 December 2020

Melatonin in sleep disorders and jet-lag

1 reference

12 December 2020

A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease.

1 reference

12 December 2020

Could agomelatine be the ideal antidepressant?

1 reference

12 December 2020

Dual coupling of MT(1) and MT(2) melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure.

1 reference

12 December 2020

Melatonin-mediated regulation of human MT(1) melatonin receptors expressed in mammalian cells

1 reference

12 December 2020

Melatonin as a candidate compound for neuroprotection in amyotrophic lateral sclerosis (ALS): high tolerability of daily oral melatonin administration in ALS patients

1 reference

12 December 2020

Continuous measurement of temperature in non-24 hour sleep-wake syndrome

1 reference

12 December 2020

Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG.

1 reference

12 December 2020

Biologic rhythm disorders, depression, and phototherapy. A new hypothesis

1 reference

12 December 2020

Twenty-four-hour melatonin and core body temperature rhythms: their adaptation in night workers

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12 December 2020

Does exogenous melatonin improve day sleep or night alertness in emergency physicians working night shifts?

1 reference

12 December 2020

Searching for new options for treating insomnia: are melatonin and ramelteon beneficial?

1 reference

12 December 2020

Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

1 reference

12 December 2020

Day-time naps and melatonin in blind people

1 reference

12 December 2020

Melatonin in older people with age-related sleep maintenance problems: a comparison with age matched normal sleepers.

1 reference

12 December 2020

Daily rhythm in human urinary melatonin

1 reference

12 December 2020

Daytime melatonin infusions induce sleep in pigeons without altering subsequent amounts of nocturnal sleep

1 reference

12 December 2020

Melatonin metabolism: neural regulation of pineal serotonin: acetyl coenzyme A N-acetyltransferase activity

1 reference

12 December 2020

Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT(2C) antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study

1 reference

12 December 2020

A two process model of sleep regulation

1 reference

12 December 2020

Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease.

1 reference

12 December 2020

Melatonin and sleep in humans

1 reference

12 December 2020

Shift work and sleep disorders.

1 reference

12 December 2020

On the effects of melatonin on sleep and behavior in man.

1 reference

12 December 2020

Evidence for melatonin synthesis in mouse and human bone marrow cells.

1 reference

12 December 2020

Effect of melatonin on circadian rhythm, locomotor activity and body temperature in the intact house sparrow, Japanese quail and owl.

1 reference

12 December 2020

Inverted rhythm of melatonin secretion in Smith-Magenis syndrome: from symptoms to treatment

1 reference

12 December 2020

Effects of exogenous melatonin on sleep: a meta-analysis

1 reference

12 December 2020

Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans

1 reference

12 December 2020

Functional MT1 and MT2 melatonin receptors in mammals

1 reference

12 December 2020

Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag.

1 reference

12 December 2020

Relationship between Napping and Melatonin in the Blind

1 reference

12 December 2020

Treatment of sleep disturbance in Alzheimer's disease

1 reference

12 December 2020

Two pedigrees of familial advanced sleep phase syndrome in Japan.

1 reference

12 December 2020

Melatonin advances the circadian timing of EEG sleep and directly facilitates sleep without altering its duration in extended sleep opportunities in humans

1 reference

12 December 2020

Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking.

1 reference

12 December 2020

HIOMT drives the photoperiodic changes in the amplitude of the melatonin peak of the Siberian hamster

1 reference

12 December 2020

Role of melatonin in the regulation of human circadian rhythms and sleep

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12 December 2020

Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies

1 reference

12 December 2020

Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor

1 reference

12 December 2020

Timing and consolidation of human sleep, wakefulness, and performance by a symphony of oscillators

1 reference

12 December 2020

Nocturnal Melatonin Secretion and Sleep after Doxepin Administration in Chronic Primary Insomnia

1 reference

12 December 2020

An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome

1 reference

12 December 2020

An efficacy, safety, and dose-response study of Ramelteon in patients with chronic primary insomnia

1 reference

12 December 2020

Beta 1-adrenergic antagonists and melatonin reset the clock and restore sleep in a circadian disorder, Smith-Magenis syndrome

1 reference

12 December 2020

Melatonin, Circadian Rhythms, and Sleep

1 reference

12 December 2020

Roles of PACAP-containing retinal ganglion cells in circadian timing

1 reference

12 December 2020

Melatonin improves evening napping.

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12 December 2020

Evidence for tryptophan hydroxylase and hydroxy-indol-O-methyl-transferase mRNAs in human blood platelets

1 reference

12 December 2020

Plasma melatonin levels and nocturnal transitions between sleep and wakefulness.

1 reference

12 December 2020

Melatonin and insomnia

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12 December 2020

Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype

1 reference

12 December 2020

The hypothalamic integrator for circadian rhythms

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12 December 2020

Gastrointestinal melatonin: localization, function, and clinical relevance

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12 December 2020

Melatonin administration can entrain the free-running circadian system of blind subjects

1 reference

12 December 2020

Prediction of melatonin efficacy by pretreatment dim light melatonin onset in children with idiopathic chronic sleep onset insomnia

1 reference

12 December 2020

Physiological changes underlying jet lag.

1 reference

12 December 2020

Use of melatonin to treat sleep disorders in tuberous sclerosis.

1 reference

12 December 2020

Agomelatine: a preliminary review of a new antidepressant

1 reference

12 December 2020

Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment

1 reference

12 December 2020

Circadian regulation dominates homeostatic control of sleep length and prior wake length in humans

1 reference

12 December 2020

Phase-shifts of 24-h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men.

1 reference

12 December 2020

Photoperiodism in humans and other primates: evidence and implications

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12 December 2020

Sleep disturbances and depression: a challenge for antidepressants

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12 December 2020

Melatonin: role in gating nocturnal rise in sleep propensity

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12 December 2020

Human pineal physiology and functional significance of melatonin

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12 December 2020

Phase-dependent treatment of delayed sleep phase syndrome with melatonin

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12 December 2020

Melatonin for sleep disturbances in Parkinson's disease

1 reference

12 December 2020

Melatonin, sleep, and shift work adaptation

1 reference

12 December 2020

Melatonin treatment of pediatric residents for adaptation to night shift work

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12 December 2020

Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans

1 reference

12 December 2020

Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance.

1 reference

12 December 2020

Effect of atenolol on nocturnal sleep and temperature in young men: reversal by pharmacological doses of melatonin

1 reference

12 December 2020

Hypnotic activity of melatonin.

1 reference

12 December 2020

Abnormal circadian rhythms of plasma melatonin and body temperature in the delayed sleep phase syndrome

1 reference

12 December 2020

Melatonin rhythms in night shift workers

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12 December 2020

Targeted disruption of the mouse Mel(1b) melatonin receptor

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12 December 2020

Regulatory sites in the melatonin system of mammals

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12 December 2020

Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist

1 reference

12 December 2020

Activation of alpha 1-adrenoceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity. Evidence that protein kinase C may participate in Ca2+-dependent alpha 1-adrenergic stimula

1 reference

12 December 2020

Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin

1 reference

12 December 2020

Ramelteon (TAK-375), a selective MT1/MT2-receptor agonist, reduces latency to persistent sleep in a model of transient insomnia related to a novel sleep environment

1 reference

12 December 2020

Signal transduction molecules in the rat pineal organ: Ca2+, pCREB, and ICER.

1 reference

12 December 2020

Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia.

1 reference

12 December 2020

Melatonin: marvel or marker?

1 reference

12 December 2020

Sleep-anticipating effects of melatonin in the human brain.

1 reference

12 December 2020

Increased bioavailability of oral melatonin after fluvoxamine coadministration.

1 reference

12 December 2020

Melatonin and delayed sleep phase syndrome: ambulatory polygraphic evaluation.

1 reference

12 December 2020

Improvement of sleep quality by controlled-release melatonin in benzodiazepine-treated elderly insomniacs

1 reference

12 December 2020

Melatonin possesses time-dependent hypnotic effects.

1 reference

12 December 2020

Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock.

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12 December 2020

The circadian visual system, 2005.

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12 December 2020

Melatonin - a chronobiotic and soporific hormone

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12 December 2020

Therapeutic potential of melatonin ligands.

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12 December 2020

Melatonin for the treatment of handicapped children with severe sleep disorders.

1 reference

12 December 2020

Circadian rhythm sleep disorders: pathophysiology and potential approaches to management

1 reference

12 December 2020

The association between the nocturnal sleep gate and nocturnal onset of urinary 6-sulfatoxymelatonin.

1 reference

12 December 2020

Human aging and melatonin. Clinical relevance.

1 reference

12 December 2020

Rapid shift in peak melatonin secretion associated with improved performance in short shift work schedule.

1 reference

12 December 2020

Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders

1 reference

12 December 2020

Sleep laboratory investigations on hypnotic properties of melatonin.

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12 December 2020

The treatment of sleep disorders with melatonin.

1 reference

12 December 2020

The use of chronobiotics in the resynchronization of the sleep-wake cycle

1 reference

12 December 2020

Long-term melatonin treatment in blind children and young adults with circadian sleep-wake disturbances.

1 reference

12 December 2020

Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn

1 reference

12 December 2020

Melatonin as a chronobiotic.

1 reference

12 December 2020

Entrainment of free-running circadian rhythms by melatonin in blind people

1 reference

12 December 2020

Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists

1 reference

12 December 2020

Correlation between concentrations of melatonin in saliva and serum in patients with delayed sleep phase syndrome

1 reference

12 December 2020

Melatonin replacement therapy of elderly insomniacs.

1 reference

12 December 2020

Melatonin shifts human circadian rhythms according to a phase-response curve

1 reference

12 December 2020

The use of melatonin in Alzheimer's disease.

1 reference

12 December 2020

Phototransduction by retinal ganglion cells that set the circadian clock

1 reference

12 December 2020

Dihydroergocryptine binding sites in bovine and rat pineal glands

1 reference

12 December 2020

Metabolism of serotonin by the rat retina in vitro

1 reference

12 December 2020

Sleep-inducing effects of low doses of melatonin ingested in the evening.

1 reference

12 December 2020

Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent.

1 reference

12 December 2020

The brain's master circadian clock: implications and opportunities for therapy of sleep disorders

1 reference

12 December 2020

The relationship between 6-sulphatoxymelatonin and polysomnographic sleep in good sleeping controls and wake maintenance insomniacs, aged 55-80 years.

1 reference

12 December 2020

Recent developments in the classification, evaluation, and treatment of insomnia

1 reference

12 December 2020

Melatonin as a hypnotic: pro.

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12 December 2020

Melatonin may be synthesised in enterochromaffin cells

1 reference

12 December 2020

Electrical synapses coordinate activity in the suprachiasmatic nucleus

1 reference

12 December 2020

Melatonin for chronic sleep onset insomnia in children: a randomized placebo-controlled trial

1 reference

12 December 2020

Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study

1 reference

12 December 2020

Insomnia in the elderly: cause, approach, and treatment

1 reference

12 December 2020

Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: alterations in preclinical and clinical stages

1 reference

12 December 2020

Melatonin promotes sleep-like state in zebrafish

1 reference

12 December 2020

Activation of MT(2) melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock

1 reference

12 December 2020

The basic physiology and pathophysiology of melatonin

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12 December 2020

Origin of cerebrospinal fluid melatonin and possible function in the integration of photoperiod.

1 reference

12 December 2020

Safety of melatonin in long-term use (?)

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12 December 2020

Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin

1 reference

12 December 2020

Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease.

1 reference

12 December 2020

Sleep patterns and mortality among elderly patients in a geriatric hospital.

1 reference

12 December 2020

The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei.

1 reference

12 December 2020

Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy

1 reference

12 December 2020

On the role of melatonin in skin physiology and pathology.

1 reference

12 December 2020

The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis

1 reference

12 December 2020

Melatonin therapy for circadian rhythm sleep disorders in children with multiple disabilities: what have we learned in the last decade?

1 reference

12 December 2020

In vitro and in vivo formation of two new metabolites of melatonin.

1 reference

12 December 2020

Melatonin promotes sleep in three species of diurnal nonhuman primates

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12 December 2020

Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin treatment.

1 reference

12 December 2020

Behavioral effects of melatonin treatment in non-human primates.

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12 December 2020

Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor

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12 December 2020

Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity

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12 December 2020

Circadian rhythm of mt1 melatonin receptor expression in the suprachiasmatic nucleus of the C3H/HeN mouse

1 reference

12 December 2020

Reduced oxidative damage in ALS by high-dose enteral melatonin treatment

1 reference

12 December 2020

Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder.

1 reference

12 December 2020

Depressed melatonin secretion in patients with nightmares due to beta-adrenoceptor blocking drugs

1 reference

12 December 2020

The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration

1 reference

12 December 2020

Sleep-promoting and hypothermic effects of daytime melatonin administration in humans

1 reference

12 December 2020

Bioavailability of melatonin in humans after day-time administration of D(7) melatonin

1 reference

12 December 2020

Ramelteon: a novel treatment for the treatment of insomnia

1 reference

12 December 2020

The role of melatonin and circadian phase in age-related sleep-maintenance insomnia: assessment in a clinical trial of melatonin replacement

1 reference

12 December 2020

Shift work sleep disorder: prevalence and consequences beyond that of symptomatic day workers.

1 reference

12 December 2020

On the effect of melatonin upon human brain. Its possible therapeutic implications

1 reference

12 December 2020

Can melatonin improve shift workers' tolerance of the night shift? Some preliminary findings.

1 reference

12 December 2020

An open-label study of controlled-release melatonin in treatment of sleep disorders in children with autism.

1 reference

12 December 2020

Sleep-promoting effects of melatonin: at what dose, in whom, under what conditions, and by what mechanisms?

1 reference

12 December 2020

Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance

1 reference

12 December 2020

Disposition kinetics and tolerance of escalating single doses of ramelteon, a high-affinity MT1 and MT2 melatonin receptor agonist indicated for treatment of insomnia

1 reference

12 December 2020

Melatonin and jet lag syndrome: experimental model and clinical implications.

1 reference

12 December 2020

N-acetyltransferase is not the rate-limiting enzyme of melatonin synthesis at night

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12 December 2020

Does melatonin play a disease-promoting role in rheumatoid arthritis?

1 reference

12 December 2020

Significant association of the arylalkylamine N-acetyltransferase (AA-NAT) gene with delayed sleep phase syndrome

1 reference

12 December 2020

Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats

1 reference

12 December 2020

Melatonin administration in insomnia

1 reference

12 December 2020

Bright light, dark and melatonin can promote circadian adaptation in night shift workers

1 reference

12 December 2020

Identification of the melatonin-binding site MT3 as the quinone reductase 2.

1 reference

12 December 2020

Agomelatine targets a range of major depressive disorder symptoms

1 reference

12 December 2020

Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial.

1 reference

12 December 2020

1 reference

12 December 2020

Analysis of adrenergic regulation of melatonin synthesis in Siberian hamster pineal emphasizes the role of HIOMT.

1 reference

12 December 2020

Polysomnographic study of the effect of melatonin on sleep in elderly patients with chronic primary insomnia.

1 reference

12 December 2020

Melatonin treatment for age-related insomnia.

1 reference

12 December 2020

Knock-down of RGS4 and beta tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization

1 reference

12 December 2020

Melatonin: clinical relevance

1 reference

12 December 2020

Melatonin in children and adolescents with insomnia: a retrospective study

1 reference

12 December 2020

Neuropsychiatric problems in tuberous sclerosis complex

1 reference

12 December 2020

Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia

1 reference

12 December 2020

Melatonin as a marker and phase-resetter of circadian rhythms in humans

1 reference

12 December 2020

Circadian phase in delayed sleep phase syndrome: predictors and temporal stability across multiple assessments.

1 reference

12 December 2020

Sleep and circadian disturbances in shift work: strategies for their management

1 reference

12 December 2020

Melatonin stabilises sleep onset time in a blind man without entrainment of cortisol or temperature rhythms

1 reference

12 December 2020

A multifactorial approach employing melatonin to accelerate resynchronization of sleep-wake cycle after a 12 time-zone westerly transmeridian flight in elite soccer athletes

1 reference

12 December 2020

Chronic exposure to melatonin receptor agonists does not alter their effects on suprachiasmatic nucleus neurons.

1 reference

12 December 2020

Modulation of melatonin receptors and G-protein function by microtubules.

1 reference

12 December 2020

Ultrashort sleep-waking schedule. III. 'Gates' and 'forbidden zones' for sleep

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12 December 2020

Melatonin and sleep in aging population

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12 December 2020

Melatonin: Nature's most versatile biological signal?

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12 December 2020

Regional brain glucose metabolism during morning and evening wakefulness in humans: preliminary findings

1 reference

12 December 2020

One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?

1 reference

12 December 2020

10.2165/00023210-200721120-00004

Identifiers

DOI

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Dimensions Publication ID

17 August 2017

1049596946

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