(Q37008837)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18028007%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

review article

1 reference

title

Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18028007%20AND%20SRC:MED&resulttype=core&format=json

amyotrophic lateral sclerosis

27 December 2019

main subject

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18028007%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Luis B Tovar-Y-Romo

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18028007%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

3

Ricardo Tapia

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18028007%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

language of work or name

English

0 references

publication date

1 November 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18028007%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

27 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18028007%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18028007%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18028007%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

page(s)

1415-1428

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18028007%20AND%20SRC:MED&resulttype=core&format=json

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

27 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Excitatory amino acids as a final common pathway for neurologic disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

On the relationship between extracellular glutamate, hyperexcitation and neurodegeneration, in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

ALS: a disease of motor neurons and their nonneuronal neighbors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Unraveling the mechanisms involved in motor neuron degeneration in ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Molecular and cellular pathways of neurodegeneration in motor neurone disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Cloned glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Review: neurotransmitter receptors. II. AMPA and kainate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

The metabotropic glutamate receptors: structure and functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Ion-coupled neurotransmitter transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Glial transporters for glutamate, glycine and GABA I. Glutamate transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Cerebral neurons of transgenic ALS mice are vulnerable to glutamate release stimulation but not to increased extracellular glutamate due to transport blockade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Late N-methyl-D-aspartate receptor blockade rescues hippocampal neurons from excitotoxic stress and death after 4-aminopyridine-induced epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Expression of heat shock protein 70 induced by 4-aminopyridine through glutamate-mediated excitotoxic stress in rat hippocampus in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Identification of a site in glutamate receptor subunits that controls calcium permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Glutamate neurotoxicity and diseases of the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Oxidative stress, glutamate, and neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Calbindin D-28k and parvalbumin in the rat nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Calcium dynamics and buffering in motoneurones of the mouse spinal cord.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Parvalbumin and calbindin D-28k in the human motor system and in motor neuron disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Parvalbumin and calbindin D-28k immunoreactivity in transgenic mice with a G93A mutant SOD1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: a molecular determinant of selective vulnerability in amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Ca(2+)-permeable AMPA receptors and selective vulnerability of motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Glutamate receptors: RNA editing and death of motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

A study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Long-term safety of riluzole in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Increased persistent Na(+) current and its effect on excitability in motoneurones cultured from mutant SOD1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Topiramate protects against motor neuron degeneration in organotypic spinal cord cultures but not in G93A SOD1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Mitochondrial dysfunction and its role in motor neuron degeneration in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Mitochondrial involvement in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Mitochondria in sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

A clinical trial of creatine in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

A two-stage design for a phase II clinical trial of coenzyme Q10 in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Manganese porphyrin given at symptom onset markedly extends survival of ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Akt/Bad signaling and motor neuron survival after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Superoxide dismutase in familial amyotrophic lateral sclerosis: models for gain of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

An RNAi strategy for treatment of amyotrophic lateral sclerosis caused by mutant Cu,Zn superoxide dismutase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Minocycline delays disease onset and mortality in a transgenic model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Characterization of the caspase cascade in a cell culture model of SOD1-related familial amyotrophic lateral sclerosis: expression, activation and therapeutic effects of inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Glial cells potentiate kainate-induced neuronal death in a motoneuron-enriched spinal coculture system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

Role of mitochondria in kainate-induced fast Ca2+ transients in cultured spinal motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415

N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1415