(Q37013966)

17 August 2017

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title

Cell penetrating peptide conjugates of steric block oligonucleotides (English)

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17 August 2017

Bernard Lebleu

1

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17 August 2017

Hong M Moulton

2

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17 August 2017

Rachida Abes

3

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17 August 2017

Gabriela D Ivanova

4

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17 August 2017

Said Abes

5

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17 August 2017

David A Stein

6

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17 August 2017

Patrick L Iversen

7

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17 August 2017

Andrey A Arzumanov

8

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17 August 2017

Michael J Gait

9

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17 August 2017

language of work or name

English

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publication date

22 October 2007

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Advanced Drug Delivery Reviews

17 August 2017

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17 August 2017

60

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17 August 2017

517-529

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17 August 2017

4-5

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Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides.

17 August 2017

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12 December 2020

Effect of 2'-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells

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12 December 2020

Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology

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12 December 2020

Photochemically induced gene silencing using PNA-peptide conjugates

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12 December 2020

Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers

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12 December 2020

Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing

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12 December 2020

Influenza fusion peptides

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12 December 2020

PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules

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12 December 2020

Delivery of bioactive molecules into the cell: the Trojan horse approach

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12 December 2020

Up-regulation of luciferase gene expression with antisense oligonucleotides: implications and applications in functional assay development

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12 December 2020

Evaluation of basic amphipathic peptides for cellular delivery of antisense peptide nucleic acids

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12 December 2020

Evaluation of Transfection Protocols for Unmodified and Modified Peptide Nucleic Acid (PNA) Oligomers

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12 December 2020

Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site.

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12 December 2020

Systemically delivered antisense oligomers upregulate gene expression in mouse tissues

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12 December 2020

Antisense oligonucleotides with different backbones. Modification of splicing pathways and efficacy of uptake

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12 December 2020

Inhibition of telomerase activity by a cell-penetrating peptide nucleic acid construct in human melanoma cells

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12 December 2020

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

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12 December 2020

Induced dystrophin exon skipping in human muscle explants

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12 December 2020

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

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12 December 2020

Evaluation of cell-penetrating peptides (CPPs) as vehicles for intracellular delivery of antisense peptide nucleic acid (PNA).

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12 December 2020

Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers

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12 December 2020

Antisense technologies. Improvement through novel chemical modifications

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12 December 2020

Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism

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12 December 2020

Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism

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12 December 2020

Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides.

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12 December 2020

Inhibition of human telomerase by PNA-cationic peptide conjugates

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12 December 2020

Silencing of microRNAs in vivo with 'antagomirs'

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12 December 2020

A specificity comparison of four antisense types: morpholino, 2'-O-methyl RNA, DNA, and phosphorothioate DNA

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12 December 2020

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

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12 December 2020

Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models

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12 December 2020

Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD.

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12 December 2020

Effects in live cells of a c-myc anti-gene PNA linked to a nuclear localization signal

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12 December 2020

Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides

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12 December 2020

Dystrophin expression in the mdx mouse after localised and systemic administration of a morpholino antisense oligonucleotide

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12 December 2020

Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells

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12 December 2020

Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing

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12 December 2020

Efficient and persistent splice switching by systemically delivered LNA oligonucleotides in mice

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12 December 2020

Targeting peptide nucleic acid-protein conjugates to structural features within duplex DNA

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12 December 2020

Photochemical internalization (PCI)--a novel technology for release of macromolecules from endocytic vesicles.

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12 December 2020

Getting hydrophilic compounds into cells: lessons from homeopeptides

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12 December 2020

A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

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12 December 2020

In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides

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12 December 2020

A structure-activity study of the inhibition of HIV-1 Tat-dependent trans-activation by mixmer 2'-O-methyl oligoribonucleotides containing locked nucleic acid (LNA), alpha-L-LNA, or 2'-thio-LNA residues.

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12 December 2020

Induction of splice correction by cell-penetrating peptide nucleic acids

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12 December 2020

Cellular uptake of unconjugated TAT peptide involves clathrin-dependent endocytosis and heparan sulfate receptors.

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12 December 2020

RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA.

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12 December 2020

Structure-activity relationship study on a simple cationic peptide motif for cellular delivery of antisense peptide nucleic acid

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12 December 2020

Calcium ions effectively enhance the effect of antisense peptide nucleic acids conjugated to cationic tat and oligoarginine peptides

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12 December 2020

HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers.

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12 December 2020

Inhibition and escape of SARS-CoV treated with antisense morpholino oligomers

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12 December 2020

Morpholino antisense oligomers: the case for an RNase H-independent structural type

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12 December 2020

Peptide-oligonucleotide conjugates for the delivery of antisense and siRNA.

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12 December 2020

Morpholino antisense oligomers: design, preparation, and properties

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12 December 2020

Endosome trapping limits the efficiency of splicing correction by PNA-oligolysine conjugates

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12 December 2020

Peptide conjugates of oligonucleotides: synthesis and applications

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12 December 2020

Cationic TAT peptide transduction domain enters cells by macropinocytosis.

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12 December 2020

Conjugates of oligonucleotides and analogues with cell penetrating peptides as gene silencing agents

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12 December 2020

Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro

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12 December 2020

Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing

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12 December 2020

Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake

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12 December 2020

Cellular delivery of polyheteroaromate-peptide nucleic acid conjugates mediated by cationic lipids

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12 December 2020

Targeting of antisense PNA oligomers to human galanin receptor type 1 mRNA.

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12 December 2020

Stability of cell-penetrating peptide-morpholino oligomer conjugates in human serum and in cells.

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12 December 2020

In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus

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12 December 2020

Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent.

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12 December 2020

Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs

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12 December 2020

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters

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12 December 2020

Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development

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12 December 2020

Inhibition of Burkitt's lymphoma cells growth in SCID mice by a PNA specific for a regulatory sequence of the translocated c-myc

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12 December 2020

Vectorization of morpholino oligomers by the (R-Ahx-R)4 peptide allows efficient splicing correction in the absence of endosomolytic agents.

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12 December 2020

Inhibition of gene expression inside cells by peptide nucleic acids: effect of mRNA target sequence, mismatched bases, and PNA length

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12 December 2020

Automated synthesis of peptide nucleic acids and peptide nucleic acid-peptide conjugates

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12 December 2020

Therapeutically promising PNA complementary to a regulatory sequence for c-myc: pharmacokinetics in an animal model of human Burkitt's lymphoma.

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12 December 2020

Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication

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12 December 2020

Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide

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12 December 2020

Morpholino oligomer-mediated exon skipping averts the onset of dystrophic pathology in the mdx mouse

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12 December 2020

Enhancement of intracellular concentration and biological activity of PNA after conjugation with a cell-penetrating synthetic model peptide.

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12 December 2020

Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate.

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12 December 2020

VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice

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12 December 2020

Comparison of basic peptides- and lipid-based strategies for the delivery of splice correcting oligonucleotides

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12 December 2020

Nucleic acid based therapeutics for tumor therapy

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12 December 2020

Synthesis and antiviral activity of peptide-oligonucleotide conjugates prepared by using N alpha-(bromoacetyl)peptides

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12 December 2020

Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo

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12 December 2020

Peptide-mediated cell delivery: application in protein target validation

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12 December 2020

Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides

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12 December 2020

Cell-dependent differential cellular uptake of PNA, peptides, and PNA-peptide conjugates

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12 December 2020

Comparative evaluation of seven oligonucleotide analogues as potential antisense agents.

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12 December 2020

Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design

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12 December 2020

Modification of alternative splicing by antisense therapeutics

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12 December 2020

Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo

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12 December 2020

Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site

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12 December 2020

Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity

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12 December 2020

Antisense therapy for cancer

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12 December 2020

Intracellular Uptake and Inhibition of Gene Expression by PNAs and PNA−Peptide Conjugates†

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12 December 2020

Bactericidal antisense effects of peptide-PNA conjugates.

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12 December 2020

10.1016/J.ADDR.2007.09.002

Identifiers

DOI

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17 August 2017

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