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Roles of the epoxygenase CYP2J2 in the endothelium.
scientific article published on 06 March 2013
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3711961
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25 February 2020
title
Roles of the epoxygenase CYP2J2 in the endothelium
(English)
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Europe PubMed Central
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3711961
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25 February 2020
main subject
endothelium
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author
Matthew L Edin
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3
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3711961
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25 February 2020
Darryl C Zeldin
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4
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25 February 2020
David Bishop-Bailey
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5
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25 February 2020
author name string
Ara Askari
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1
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25 February 2020
Scott J Thomson
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2
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25 February 2020
publication date
6 March 2013
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25 February 2020
published in
Prostaglandins and Other Lipid Mediators
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25 February 2020
volume
107
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25 February 2020
page(s)
56-63
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25 February 2020
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A keratinocyte-specific epoxygenase, CYP2B12, metabolizes arachidonic acid with unusual selectivity, producing a single major epoxyeicosatrienoic acid
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Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart
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Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
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29 September 2017
The vascular endothelium: a survey of some newly evolving biochemical and physiological features
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
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29 September 2017
Human cyclooxygenase-2 cDNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
29 September 2017
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
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29 September 2017
Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
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27 June 2018
Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
27 June 2018
CYP2J2 -50 G/T and ADRB2 G46A gene polymorphisms in Saudi subjects with hypertension
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
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4 September 2018
Identification of novel substrates for human cytochrome P450 2J2.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
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4 September 2018
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
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4 September 2018
Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
11,12-Epoxyeicosatrienoic acid activates the L-arginine/nitric oxide pathway in human platelets
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
Arachidonic acid epoxygenase metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
Identification, functional characterization, and regulation of a new cytochrome P450 subfamily, the CYP2Ns
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 September 2018
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711961
retrieved
4 December 2018
Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23474289
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23474289
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
COX-2 in cardiovascular disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23474289
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The potential use of the pregnane X receptor in cardiovascular therapy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23474289
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6-nephrectomized rat via inhibition of apoptosis and fibrosis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23474289
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23474289
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23474289
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.PROSTAGLANDINS.2013.02.003
1 reference
stated in
Europe PubMed Central
PMC publication ID
3711961
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23474289%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
PMC publication ID
3711961
1 reference
stated in
Europe PubMed Central
PMC publication ID
3711961
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23474289%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
PubMed publication ID
23474289
1 reference
stated in
Europe PubMed Central
PMC publication ID
3711961
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23474289%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
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