(Q37017125)

17 August 2017

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title

Heterotrimeric G protein activation by G-protein-coupled receptors (English)

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G protein-coupled receptor

17 August 2017

main subject

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William M Oldham

1

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author name string

Heidi E Hamm

series ordinal

2

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17 August 2017

publication date

1 January 2008

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Nature Reviews Molecular Cell Biology

17 August 2017

published in

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17 August 2017

volume

9

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17 August 2017

issue

1

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17 August 2017

page(s)

60-71

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https://scigraph.springernature.com/pub.10.1038/nrm2299

17 August 2017

exact match

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cites work

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Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

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Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains

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Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein

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Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis

31 March 2020

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The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S

31 March 2020

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Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

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Regulation of G proteins by covalent modification

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The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

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Crystal structure of a G-protein beta gamma dimer at 2.1A resolution

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Protein prenylation: molecular mechanisms and functional consequences

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G protein beta gamma subunits.

31 March 2020

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Studies on the interaction of alpha subunits of GTP-binding proteins with beta gamma dimers

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The 2.0 A crystal structure of a heterotrimeric G protein

31 March 2020

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Molecular determinants of the reversible membrane anchorage of the G-protein transducin.

31 March 2020

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Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit

31 March 2020

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Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

31 March 2020

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Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.

31 March 2020

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Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling.

31 March 2020

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Agonist-induced conformational changes in thyrotropin-releasing hormone receptor type I: disulfide cross-linking and molecular modeling approaches.

31 March 2020

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Use of an in situ disulfide cross-linking strategy to study the dynamic properties of the cytoplasmic end of transmembrane domain VI of the M3 muscarinic acetylcholine receptor

31 March 2020

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G protein-coupled receptor rhodopsin

31 March 2020

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Measurement of the millisecond activation switch of G protein-coupled receptors in living cells

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Structural basis for activation of G-protein-coupled receptors

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Mode of coupling between the β-adrenergic receptor and adenylate cyclase in turkey erythrocytes

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Rhodopsin activation exposes a key hydrophobic binding site for the transducin alpha-subunit C terminus

31 March 2020

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NMR structure of a receptor-bound G-protein peptide

31 March 2020

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Light-activated rhodopsin induces structural binding motif in G protein alpha subunit

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Structure and orientation of a G protein fragment in the receptor bound state from residual dipolar couplings

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Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit

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Structural requirements for the stabilization of metarhodopsin II by the C terminus of the alpha subunit of transducin.

31 March 2020

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Potent peptide analogues of a G protein receptor-binding region obtained with a combinatorial library

31 March 2020

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Identification of receptor contact site involved in receptor-G protein coupling

31 March 2020

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The effect of carboxyl-terminal mutagenesis of Gt alpha on rhodopsin and guanine nucleotide binding

31 March 2020

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Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin

31 March 2020

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Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation

31 March 2020

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Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex

31 March 2020

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Mapping of contact sites in complex formation between transducin and light-activated rhodopsin by covalent crosslinking: use of a photoactivatable reagent

31 March 2020

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Interaction of Transducin with Light-activated Rhodopsin Protects It from Proteolytic Digestion by Trypsin

31 March 2020

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Mapping of contact sites in complex formation between light-activated rhodopsin and transducin by covalent crosslinking: use of a chemically preactivated reagent

31 March 2020

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The amino terminus of Galpha(z) is required for receptor recognition, whereas its alpha4/beta6 loop is essential for inhibition of adenylyl cyclase

31 March 2020

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Receptor and membrane interaction sites on Gbeta. A receptor-derived peptide binds to the carboxyl terminus.

31 March 2020

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Molecular basis for interactions of G protein betagamma subunits with effectors

31 March 2020

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Receptor-G protein coupling is established by a potential conformational switch in the beta gamma complex

31 March 2020

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Rhodopsin controls a conformational switch on the transducin gamma subunit

31 March 2020

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A G protein gamma subunit-specific peptide inhibits muscarinic receptor signaling

31 March 2020

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The ants go marching two by two: oligomeric structure of G-protein-coupled receptors.

31 March 2020

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G protein-coupled receptor dimerization: function and ligand pharmacology

31 March 2020

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Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein

31 March 2020

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Rhodopsin dimers in native disc membranes

31 March 2020

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Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

31 March 2020

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G-protein-coupled receptor oligomerization and its potential for drug discovery

31 March 2020

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Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.

31 March 2020

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Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR

31 March 2020

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Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction

31 March 2020

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A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

31 March 2020

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Sequence of interactions in receptor-G protein coupling.

31 March 2020

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Signal transfer from GPCRs to G proteins: role of the G alpha N-terminal region in rhodopsin-transducin coupling.

31 March 2020

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Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha

31 March 2020

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Extreme C terminus of G protein alpha-subunits contains a site that discriminates between Gi-coupled metabotropic glutamate receptors

31 March 2020

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Genetic analysis of receptor-Galphaq coupling selectivity

31 March 2020

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Rhodopsin recognition by mutant G(s)alpha containing C-terminal residues of transducin

31 March 2020

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Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits

31 March 2020

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The N-terminal extension of Galphaq is critical for constraining the selectivity of receptor coupling

31 March 2020

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Functional characterization of a series of mutant G protein alphaq subunits displaying promiscuous receptor coupling properties

31 March 2020

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A novel site on the Galpha -protein that recognizes heptahelical receptors

31 March 2020

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31 March 2020

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Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction

31 March 2020

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A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity

31 March 2020

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The G protein beta subunit is a determinant in the coupling of Gs to the beta 1-adrenergic and A2a adenosine receptors

31 March 2020

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Selective role of G protein gamma subunits in receptor interaction

31 March 2020

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Gbetagamma affinity for bovine rhodopsin is determined by the carboxyl-terminal sequences of the gamma subunit

31 March 2020

1 reference

Role of the prenyl group on the G protein gamma subunit in coupling trimeric G proteins to A1 adenosine receptors

31 March 2020

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Molecular basis of receptor/G-protein-coupling selectivity

31 March 2020

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Specificity of receptor-G protein interactions: searching for the structure behind the signal.

31 March 2020

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The luteinizing hormone/chorionic gonadotropin receptor has distinct transmembrane conductors for cAMP and inositol phosphate signals

31 March 2020

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Ligand-selective receptor conformations revisited: the promise and the problem

31 March 2020

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Multiple signaling states of G-protein-coupled receptors

31 March 2020

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Chemically distinct ligands promote differential CB1 cannabinoid receptor-Gi protein interactions.

31 March 2020

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Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.

31 March 2020

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Complex formation between metarhodopsin II and GTP-binding protein in bovine photoreceptor membranes leads to a shift of the photoproduct equilibrium

31 March 2020

1 reference

The transitory complex between photoexcited rhodopsin and transducin. Reciprocal interaction between the retinal site in rhodopsin and the nucleotide site in transducin.

31 March 2020

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How receptors talk to trimeric G proteins

31 March 2020

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The many faces of G protein signaling

31 March 2020

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The G protein-coupled receptor rhodopsin in the native membrane

31 March 2020

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A hypothesis for GPCR activation

31 March 2020

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Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function

31 March 2020

1 reference

The A326S mutant of Gialpha1 as an approximation of the receptor-bound state

31 March 2020

1 reference

G-protein alpha o subunit: mutation of conserved cysteines identifies a subunit contact surface and alters GDP affinity

31 March 2020

1 reference

Rapid activation of transducin by mutations distant from the nucleotide-binding site: evidence for a mechanistic model of receptor-catalyzed nucleotide exchange by G proteins

31 March 2020

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Disruption of the alpha5 helix of transducin impairs rhodopsin-catalyzed nucleotide exchange

31 March 2020

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Probing the mechanism of rhodopsin-catalyzed transducin activation.

31 March 2020

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Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins

31 March 2020

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Molecular dynamics simulations of transducin: interdomain and front to back communication in activation and nucleotide exchange.

31 March 2020

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RETRACTED: Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity

31 March 2020

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Mutations at the domain interface of GSalpha impair receptor-mediated activation by altering receptor and guanine nucleotide binding

31 March 2020

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A switch 3 point mutation in the alpha subunit of transducin yields a unique dominant-negative inhibitor

31 March 2020

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Interactions between the amino- and carboxyl-terminal regions of G alpha subunits: analysis of mutated G alpha o/G alpha i2 chimeras

31 March 2020

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G-protein diseases furnish a model for the turn-on switch

31 March 2020

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Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation?

31 March 2020

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Activation of G-protein Galpha subunits by receptors through Galpha-Gbeta and Galpha-Ggamma interactions

31 March 2020

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G protein gamma subunit interaction with a receptor regulates receptor-stimulated nucleotide exchange

31 March 2020

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Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange

31 March 2020

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Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation

31 March 2020

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Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway

31 March 2020

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Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins

31 March 2020

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A novel mutation in the switch 3 region of Gsalpha in a patient with Albright hereditary osteodystrophy impairs GDP binding and receptor activation

31 March 2020

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A mutation in the heterotrimeric stimulatory guanine nucleotide binding protein alpha-subunit with impaired receptor-mediated activation because of elevated GTPase activity.

31 March 2020

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Interdomain interactions regulate GDP release from heterotrimeric G proteins

31 March 2020

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The function of interdomain interactions in controlling nucleotide exchange rates in transducin

31 March 2020

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Perturbing the linker regions of the alpha-subunit of transducin: a new class of constitutively active GTP-binding proteins

31 March 2020

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Maximal rate and nucleotide dependence of rhodopsin-catalyzed transducin activation: initial rate analysis based on a double displacement mechanism

31 March 2020

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Gi protein activation in intact cells involves subunit rearrangement rather than dissociation

31 March 2020

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Real-time monitoring of receptor and G-protein interactions in living cells.

31 March 2020

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Some G protein heterotrimers physically dissociate in living cells

31 March 2020

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Gs activation is time-limiting in initiating receptor-mediated signaling.

31 March 2020

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Rapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins

31 March 2020

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Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.

31 March 2020

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Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

31 March 2020

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Molecular determinants of selectivity in 5-hydroxytryptamine1B receptor-G protein interactions

31 March 2020

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7 January 2021

Two amino acids within the alpha4 helix of Galphai1 mediate coupling with 5-hydroxytryptamine1B receptors

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7 January 2021

Regions in the G protein gamma subunit important for interaction with receptors and effectors.

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7 January 2021

The carboxyl terminus of the Galpha-subunit is the latch for triggered activation of heterotrimeric G proteins

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7 January 2021

Identifiers

DOI

10.1038/NRM2299

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Dimensions Publication ID

17 August 2017

1027419051

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