(Q37026304)

English

Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

0 references

0 references

0 references

frontotemporal dementia

1 reference

based on heuristic

inferred from title

Adolfo López de Munain

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26624524%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Angeles Martín-Requero

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26624524%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Carolina Alquézar

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26624524%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Ana de la Encarnación

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26624524%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Fermín Moreno

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26624524%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

language of work or name

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publication date

30 November 2015

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17 August 2017

Journal of Psychiatry & Neuroscience

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8 June 2020

41

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Europe PubMed Central

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8 June 2020

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26624524%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

225-239

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26624524%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

PGRN induces impaired insulin sensitivity and defective autophagy in hepatic insulin resistance

1 reference

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29 September 2017

Profiling of ubiquitination pathway genes in peripheral cells from patients with frontotemporal dementia due to C9ORF72 and GRN mutations

1 reference

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29 September 2017

Targeting TNF: a therapeutic strategy for Alzheimer's disease

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29 September 2017

Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity.

1 reference

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29 September 2017

An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy

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29 September 2017

Frontotemporal lobar degeneration: current perspectives

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29 September 2017

Calmodulin levels in blood cells as a potential biomarker of Alzheimer's disease

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29 September 2017

SQSTM1 mutations in French patients with frontotemporal dementia or frontotemporal dementia with amyotrophic lateral sclerosis

1 reference

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29 September 2017

The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment

1 reference

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29 September 2017

The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling

1 reference

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29 September 2017

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

29 September 2017

Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression

1 reference

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29 September 2017

Differential regulation of the mouse and human Wnt5a alternative promoters A and B.

1 reference

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29 September 2017

Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

29 September 2017

Inactivation of CDK/pRb pathway normalizes survival pattern of lymphoblasts expressing the FTLD-progranulin mutation c.709-1G>A

1 reference

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29 September 2017

Signal transduction by tumor necrosis factor receptors

1 reference

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29 September 2017

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways

1 reference

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29 September 2017

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

1 reference

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29 September 2017

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

29 September 2017

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

1 reference

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29 September 2017

Structure, function, and mechanism of progranulin; the brain and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

29 September 2017

A harmonized classification system for FTLD-TDP pathology

1 reference

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29 September 2017

Novel types of frontotemporal lobar degeneration: beyond tau and TDP-43.

1 reference

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29 September 2017

Progranulin: a promising therapeutic target for rheumatoid arthritis.

1 reference

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29 September 2017

Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

29 September 2017

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice

1 reference

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29 September 2017

Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.

1 reference

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29 September 2017

Genetic causes of frontotemporal degeneration

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29 September 2017

The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease

1 reference

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29 September 2017

Emerging roles of Wnts in the adult nervous system

1 reference

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29 September 2017

The heritability and genetics of frontotemporal lobar degeneration.

1 reference

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29 September 2017

TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy

1 reference

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29 September 2017

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

1 reference

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29 September 2017

The Toll-->NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila

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29 September 2017

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

1 reference

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29 September 2017

Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

1 reference

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29 September 2017

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

29 September 2017

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

1 reference

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29 September 2017

Modified expression of Bcl-2 and SOD1 proteins in lymphocytes from sporadic ALS patients

1 reference

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29 September 2017

Altered transcriptional regulators in response to serum in immortalized lymphocytes from Alzheimer's disease patients.

1 reference

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29 September 2017

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding [...]

1 reference

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29 September 2017

IkappaB kinases: key regulators of the NF-kappaB pathway

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29 September 2017

Alzheimer's disease: the two-hit hypothesis

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29 September 2017

Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

1 reference

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29 September 2017

The prevalence of frontotemporal dementia

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29 September 2017

Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease

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29 September 2017

Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria

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29 September 2017

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1 reference

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29 September 2017

Human tumor necrosis factor receptor p75/80 (CD120b) gene structure and promoter characterization

1 reference

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29 September 2017

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli

1 reference

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29 September 2017

NF-kappa B and rel proteins in innate immunity

1 reference

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29 September 2017

Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

1 reference

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29 September 2017

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

29 September 2017

Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability

1 reference

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29 September 2017

Highly pathogenic Alzheimer's disease presenilin 1 P117R mutation causes a specific increase in p53 and p21 protein levels and cell cycle dysregulation in human lymphocytes.

1 reference

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27 June 2018

Distinct pH homeostatic features in lymphoblasts from Alzheimer's disease patients.

1 reference

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27 June 2018

Diagnosis of neurometabolic disorders by examination of skin biopsies and lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

27 June 2018

G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

4 September 2018

Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

4 September 2018

PGRN haploinsufficiency increased Wnt5a signaling in peripheral cells from frontotemporal lobar degeneration-progranulin mutation carriers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

4 September 2018

Clinical variability and female penetrance in X-linked familial FTD/ALS caused by a P506S mutation in UBQLN2.

1 reference

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4 September 2018

Distinctive age-related temporal cortical thinning in asymptomatic granulin gene mutation carriers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

4 September 2018

Neuropsychological features of asymptomatic c.709-1G>A progranulin mutation carriers.

1 reference

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4 September 2018

Genetics and expression analysis of the specificity protein 4 gene (SP4) in patients with Alzheimer's disease and frontotemporal lobar degeneration.

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4 September 2018

Alteration in cell cycle-related proteins in lymphoblasts from carriers of the c.709-1G>A PGRN mutation associated with FTLD-TDP dementia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

4 September 2018

Requirement of the NF-κB pathway for induction of Wnt-5A by interleukin-1β in condylar chondrocytes of the temporomandibular joint: functional crosstalk between the Wnt-5A and NF-κB signaling pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4915932

4 September 2018

Multivariate analysis of differential lymphocyte cell cycle activity in Alzheimer's disease

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4 September 2018

Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades

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4 September 2018

[Clinical and biomolecular classification of the frontotemporal dementias. A review of the literature].

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4 September 2018

Frontotemporal dementia.

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4 September 2018

p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain

1 reference

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4 September 2018

Evaluating the comparability of gene expression in blood and brain.

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4 September 2018

Cell cycle activation linked to neuronal cell death initiated by DNA damage

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4 September 2018

Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex

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4 September 2018

Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment.

1 reference

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4 September 2018

NF-kB immunoreactivity is observed in association with beta A4 diffuse plaques in patients with Alzheimer's disease

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4 September 2018

The cell division cycle and the pathophysiology of Alzheimer's disease

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4 September 2018

Tau is a candidate gene for chromosome 17 frontotemporal dementia

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4 September 2018

Frontotemporal dementia

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diversity and regulation in the NF-kappaB system

1 reference

https://pubmed.ncbi.nlm.nih.gov/26624524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Reassessment of the Neuropathology of Frontotemporal Dementia Linked to Chromosome 3

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https://pubmed.ncbi.nlm.nih.gov/26624524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling pathway is involved in the pathogenesis of amyotrophic lateral sclerosis in adult transgenic mice

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1503/JPN.150131

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26624524%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26624524%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26624524%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

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