(Q37030891)

17 August 2017

1 reference

title

Applying small RNA molecules to the directed treatment of human diseases: realizing the potential (English)

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17 August 2017

Todd C Pappas

1

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17 August 2017

Andreas G Bader

2

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17 August 2017

Bernard F Andruss

3

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17 August 2017

David Brown

4

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17 August 2017

Lance P Ford

5

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17 August 2017

language of work or name

English

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publication date

1 January 2008

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Expert Opinion on Therapeutic Targets

17 August 2017

published in

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17 August 2017

volume

12

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17 August 2017

issue

1

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17 August 2017

page(s)

115-127

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Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia

21 January 2018

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Down-regulation of integrin alpha(v)beta(3) expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.12.1.115

A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Gene therapy progress and prospects: RNA aptamers

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.12.1.115

DNA and RNA aptamers: from tools for basic research towards therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Oligonucleotide NX1838 inhibits VEGF165-mediated cellular responses in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Killing the messenger: short RNAs that silence gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Oncomirs - microRNAs with a role in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Designing siRNA that distinguish between genes that differ by a single nucleotide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Allele-specific silencing of dominant disease genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Rational siRNA design for RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

A microRNA in a multiple-turnover RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Comparison of siRNA-induced off-target RNA and protein effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

In vivo activity of nuclease-resistant siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Two classes of short interfering RNA in RNA silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

MicroRNA-directed cleavage of HOXB8 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

MicroRNAs direct rapid deadenylation of mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Viral virulence protein suppresses RNA silencing-mediated defense but upregulates the role of microrna in host gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

The let-7 microRNA represses cell proliferation pathways in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Prediction and validation of microRNAs and their targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

A microRNA expression signature of human solid tumors defines cancer gene targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

MicroRNA signatures in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

The colorectal microRNAome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Elucidation of the small RNA component of the transcriptome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

A microRNA polycistron as a potential human oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

RAS is regulated by the let-7 microRNA family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

miR-15 and miR-16 induce apoptosis by targeting BCL2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Reduced expression of Dicer associated with poor prognosis in lung cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

RNA interference in adult mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Caspase 8 small interfering RNA prevents acute liver failure in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

siRNA relieves chronic neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Use of anionic liposomes for the reduction of chronic doxorubicin-induced cardiotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

RNA interference: from gene silencing to gene-specific therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Developments in liposomal drug delivery systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Liposome-mediated delivery of oligodeoxynucleotides in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

DNA-based therapeutics and DNA delivery systems: a comprehensive review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Linear cyclodextrin-containing polymers and their use as delivery agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Identification of novel genes coding for small expressed RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

miR-21-mediated tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

A Correlation between Surface Charge and Coagulant Action of Phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.1.115

10.1517/14728222.12.1.115

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference