(Q33215530)

24 July 2017

2 references

22 August 2022

RNA interference: from gene silencing to gene-specific therapeutics (English)

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24 July 2017

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Ray K M Leung

1

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24 July 2017

Paul A Whittaker

series ordinal

2

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24 July 2017

publication date

1 August 2005

2 references

Pharmacology & Therapeutics

24 July 2017

22 August 2022

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24 July 2017

22 August 2022

107

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24 July 2017

issue

2

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24 July 2017

page(s)

222-239

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EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy

24 July 2017

cites work

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12 December 2020

Genomics and malaria control

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12 December 2020

In vivo activity of nuclease-resistant siRNAs

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12 December 2020

Clinical potential of respirable antisense oligonucleotides (RASONs) in asthma

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12 December 2020

Functional genomics in virology and antiviral drug discovery

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12 December 2020

Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference

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12 December 2020

RNA interference: antiviral weapon and beyond

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12 December 2020

BACE1 Suppression by RNA Interference in Primary Cortical Neurons

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12 December 2020

Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis

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12 December 2020

Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells

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12 December 2020

Genome-wide RNAi screens in Caenorhabditis elegans: impact on cancer research

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12 December 2020

Revealing the world of RNA interference

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12 December 2020

Epithelial cells and fibroblasts: structural repair and remodelling in the airways.

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12 December 2020

Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells.

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12 December 2020

Small interfering RNA Inhibits Hepatitis B virus replication in mice

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12 December 2020

Role for a bidentate ribonuclease in the initiation step of RNA interference

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12 December 2020

RNA interference in mammalian cells by chemically-modified RNA.

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12 December 2020

Small RNA: can RNA interference be exploited for therapy?

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12 December 2020

Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cell-derived macrophages

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12 December 2020

Genomic instability and cancer: scanning the Caenorhabditis elegans genome for tumor suppressors

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12 December 2020

Rho GTPases: potential candidates for anticancer therapy

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12 December 2020

Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation

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12 December 2020

p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6

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12 December 2020

BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways

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12 December 2020

Control of siRNA expression using the Cre-loxP recombination system.

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12 December 2020

RNAi (Nematodes: Caenorhabditis elegans).

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12 December 2020

Nucleotide sequence homology requirements of HIV-1-specific short hairpin RNA

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12 December 2020

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

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12 December 2020

Genetically engineered mouse models for lung cancer.

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12 December 2020

Genomewide view of gene silencing by small interfering RNAs

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12 December 2020

Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells

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12 December 2020

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

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12 December 2020

Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype.

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12 December 2020

siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme

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12 December 2020

Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene

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12 December 2020

Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference

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12 December 2020

Rational siRNA design for RNA interference

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12 December 2020

Localized permanent epidemics: the genesis of chloroquine resistance in Plasmodium falciparum.

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12 December 2020

A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs

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12 December 2020

Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells

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12 December 2020

High-throughput RNAi in Caenorhabditis elegans: genome-wide screens and functional genomics

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12 December 2020

Gel-Based Application of siRNA to Human Epithelial Cancer Cells Induces RNAi-Dependent Apoptosis

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12 December 2020

Progress in antisense technology.

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12 December 2020

A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens

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12 December 2020

Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer

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12 December 2020

A micrococcal nuclease homologue in RNAi effector complexes

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12 December 2020

The development of imatinib as a therapeutic agent for chronic myeloid leukemia

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12 December 2020

Strategies for generation of an siRNA expression library directed against the human genome.

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12 December 2020

Conditional gene knock-down by CRE-dependent short interfering RNAs

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12 December 2020

Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans

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12 December 2020

Systemic delivery of synthetic siRNAs

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12 December 2020

RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

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12 December 2020

siRNAs can function as miRNAs

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12 December 2020

Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo.

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12 December 2020

RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

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12 December 2020

Lack of interferon response in animals to naked siRNAs

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12 December 2020

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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12 December 2020

Challenges and strategies: the immune responses in gene therapy

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12 December 2020

Expanding small RNA interference

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12 December 2020

Interfering with hepatitis C virus RNA replication

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12 December 2020

The immunogenetics of asthma and eczema: a new focus on the epithelium

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12 December 2020

RNA interference: from model organisms towards therapy for neural and neuromuscular disorders

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12 December 2020

Gene therapy. Second child in French trial is found to have leukemia

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12 December 2020

Expression profiling reveals off-target gene regulation by RNAi

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12 December 2020

Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo.

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12 December 2020

The RAF proteins take centre stage

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12 December 2020

siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells

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12 December 2020

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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12 December 2020

Validation of GABA(A) receptor subtypes as potential drug targets by using genetically modified mice

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12 December 2020

Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury.

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12 December 2020

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12 December 2020

Long-lasting RNAi activity in mammalian neurons

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12 December 2020

Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potency

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12 December 2020

What is the relevance of bioinformatics to pharmacology?

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12 December 2020

Many commonly used siRNAs risk off-target activity

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12 December 2020

Systematic genome-wide screens of gene function

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12 December 2020

siRNA-mediated down-regulation of survivin inhibits bladder cancer cell growth

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12 December 2020

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

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12 December 2020

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

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12 December 2020

Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter.

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12 December 2020

Stable suppression of tumorigenicity by virus-mediated RNA interference

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12 December 2020

RNA-interference-based functional genomics in mammalian cells: reverse genetics coming of age.

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12 December 2020

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

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12 December 2020

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

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12 December 2020

Electroporation and RNA interference in the rodent retina in vivo and in vitro

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12 December 2020

RNA interference targeting Fas protects mice from fulminant hepatitis

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12 December 2020

An approach to genomewide screens of expressed small interfering RNAs in mammalian cells.

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12 December 2020

Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons

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12 December 2020

Use of siRNAs to prevent and treat influenza virus infection

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12 December 2020

Gene silencing in alveolar type II cells using cell-specific promoter in vitro and in vivo

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12 December 2020

Induction of an interferon response by RNAi vectors in mammalian cells

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12 December 2020

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

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12 December 2020

Exogenous siRNA mediates sequence-independent gene suppression by signaling through toll-like receptor 3.

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12 December 2020

Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice

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12 December 2020

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

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12 December 2020

The utility of siRNA transcripts produced by RNA polymerase i in down regulating viral gene expression and replication of negative- and positive-strand RNA viruses

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12 December 2020

The promyelotic leukemia zinc finger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1.

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12 December 2020

Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis

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12 December 2020

Inhibition of influenza virus production in virus-infected mice by RNA interference

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12 December 2020

Efficient gene transfer of HIV-1-specific short hairpin RNA into human lymphocytic cells using recombinant adeno-associated virus vectors

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12 December 2020

The multiple orthogonal tools approach to define molecular causation in the validation of druggable targets

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12 December 2020

Characterization of RNA interference in an Anopheles gambiae cell line

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12 December 2020

Breakthrough of the year. Small RNAs make big splash

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12 December 2020

Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle.

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12 December 2020

Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery.

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12 December 2020

Caspase 8 small interfering RNA prevents acute liver failure in mice

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12 December 2020

Synthetic shRNAs as potent RNAi triggers.

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12 December 2020

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

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12 December 2020

B-RAF is a therapeutic target in melanoma

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12 December 2020

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA.

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12 December 2020

Molecular biology. RNAi shows cracks in its armor

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12 December 2020

Killing the messenger

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12 December 2020

Drug development for ovarian hyper-stimulation and anti-cancer treatment: blocking of gonadotropin signaling for epiregulin and amphiregulin biosynthesis.

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12 December 2020

Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research

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12 December 2020

siRNA cell arrays for high-content screening microscopy

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12 December 2020

Inhibiting severe acute respiratory syndrome-associated coronavirus by small interfering RNA.

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12 December 2020

Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads

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12 December 2020

Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer

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12 December 2020

Delivery of small interfering RNA to mammalian cells in culture by using cationic lipid/polymer-based transfection reagents

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12 December 2020

Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases

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12 December 2020

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

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12 December 2020

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

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12 December 2020

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

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12 December 2020

Delivery of siRNA and siRNA expression constructs to adult mammals by hydrodynamic intravascular injection

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12 December 2020

Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells

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12 December 2020

RNA interference using boranophosphate siRNAs: structure-activity relationships

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12 December 2020

The DNA double-stranded break repair protein endo-exonuclease as a therapeutic target for cancer.

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12 December 2020

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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12 December 2020

Establishment of conditional vectors for hairpin siRNA knockdowns

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12 December 2020

Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression.

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12 December 2020

Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin.

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12 December 2020

Suppression of bcl-2 gene by RNA interference increases chemosensitivity to cisplatin in nasopharyngeal carcinoma cell line CNE1.

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12 December 2020

Genes for asthma: much ado about nothing?

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12 December 2020

Improving the efficiency of RNA interference in mammals

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12 December 2020

Inhibition of porcine endogenous retroviruses by RNA interference: increasing the safety of xenotransplantation.

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12 December 2020

The genetics of RNA silencing

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12 December 2020

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.

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12 December 2020

Adenoviral vectors expressing siRNAs for discovery and validation of gene function

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12 December 2020

Inhibition of severe acute respiratory syndrome virus replication by small interfering RNAs in mammalian cells

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12 December 2020

Expression profiling of cardiovascular disease

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12 December 2020

AKT involvement in cisplatin chemoresistance of human uterine cancer cells

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12 December 2020

Small interfering RNA and gene silencing in transgenic mice and rats

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12 December 2020

siRNA-mediated gene silencing in vitro and in vivo.

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12 December 2020

Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.

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12 December 2020

The silent revolution: RNA interference as basic biology, research tool, and therapeutic

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12 December 2020

An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

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12 December 2020

Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways.

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12 December 2020

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12 December 2020

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

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12 December 2020

The nuclear RNase III Drosha initiates microRNA processing

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12 December 2020

Interfering with disease: opportunities and roadblocks to harnessing RNA interference

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12 December 2020

Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo

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12 December 2020

Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

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12 December 2020

Double-stranded siRNA targeted to the huntingtin gene does not induce DNA methylation

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12 December 2020

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12 December 2020

Double-stranded RNA mediates homology-dependent gene silencing of gamma-tubulin in the human parasite Entamoeba histolytica

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12 December 2020

Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry

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12 December 2020

Biodistribution of phosphodiester and phosphorothioate siRNA.

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12 December 2020

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

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12 December 2020

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

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12 December 2020

Characterisation and expression of a PP1 serine/threonine protein phosphatase (PfPP1) from the malaria parasite, Plasmodium falciparum: demonstration of its essential role using RNA interference

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12 December 2020

siRNA-mediated gene silencing: a global genome view

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12 December 2020

Inhibition of hepatitis B virus surface antigen expression by small hairpin RNA in vitro

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12 December 2020

Unlocking the money-making potential of RNAi.

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12 December 2020

Killing the messenger: short RNAs that silence gene expression

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12 December 2020

Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference

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12 December 2020

RNA interference in vivo: toward synthetic small inhibitory RNA-based therapeutics

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12 December 2020

Two classes of short interfering RNA in RNA silencing

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12 December 2020

A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA.

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12 December 2020

RNA interference in Caenorhabditis elegans

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12 December 2020

Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies.

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12 December 2020

Role of hypoxia-inducible factor-1alpha in hypoxia-induced apoptosis of primary alveolar epithelial type II cells

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12 December 2020

Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference

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12 December 2020

CRE recombinase-inducible RNA interference mediated by lentiviral vectors

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12 December 2020

Asymmetry in the assembly of the RNAi enzyme complex

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12 December 2020

p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop

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12 December 2020

Pathogenesis of amebiasis

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12 December 2020

Inflammation and repair processes in chronic obstructive pulmonary disease

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12 December 2020

Antiviral effects of human immunodeficiency virus type 1-specific small interfering RNAs against targets conserved in select neurotropic viral strains

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12 December 2020

A resource for large-scale RNA-interference-based screens in mammals.

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12 December 2020

Activation of the interferon system by short-interfering RNAs

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12 December 2020

Sequence-dependent and independent inhibition specific for mutant ataxin-3 by small interfering RNA.

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12 December 2020

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

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12 December 2020

Functional genomics using high-throughput RNA interference

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12 December 2020

Gene silencing by systemic delivery of synthetic siRNAs in adult mice

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12 December 2020

DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways

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12 December 2020

Innate immunity in the malaria vector Anopheles gambiae: comparative and functional genomics

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12 December 2020

CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells

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12 December 2020

Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells

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12 December 2020

Drug discovery: a historical perspective

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12 December 2020

RNAi as a tool to study cell biology: building the genome-phenome bridge

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12 December 2020

MicroRNAs: genomics, biogenesis, mechanism, and function

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12 December 2020

Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference

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12 December 2020

Genome-wide RNAi as a route to gene function in Drosophila.

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12 December 2020

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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12 December 2020

Challenges for RNAi in vivo

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12 December 2020

Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA.

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12 December 2020

Role of transforming growth factor beta in human disease

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12 December 2020

Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs.

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12 December 2020

Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing

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12 December 2020

New non-viral method for gene transfer into primary cells.

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12 December 2020

RNAi-induced gene silencing by local electroporation in targeting brain region.

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12 December 2020

Using siRNA technique to generate transgenic animals with spatiotemporal and conditional gene knockdown

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12 December 2020

Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs

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12 December 2020

High-throughput gene silencing using cell arrays.

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12 December 2020

Natural and engineered nucleic acids as tools to explore biology

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12 December 2020

Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2.

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12 December 2020

Local gene knockdown in the brain using viral-mediated RNA interference.

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12 December 2020

Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis

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12 December 2020

Enhanced delivery of naked DNA to the skin by non-invasive in vivo electroporation

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12 December 2020

Determinants of hepatitis C translational initiation in vitro, in cultured cells and mice

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12 December 2020

Noise amidst the silence: off-target effects of siRNAs?

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12 December 2020

High-throughput selection of effective RNAi probes for gene silencing.

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12 December 2020

[Specific inhibition of hTERT gene expression by short interfering RNAs in gastric cancer SGC7901 cell].

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12 December 2020

Inducible, reversible, and stable RNA interference in mammalian cells

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12 December 2020

Syk tyrosine kinase participates in beta1-integrin signaling and inflammatory responses in airway epithelial cells

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12 December 2020

Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression

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12 December 2020

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

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12 December 2020

Effects of mosquito genes on Plasmodium development

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12 December 2020

Pulmonary function changes in children after respiratory syncytial virus infection in infancy

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12 December 2020

Deaths: final data for 1998.

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12 December 2020

Determinants of prognosis of COPD in the elderly: mucus hypersecretion, infections, cardiovascular comorbidity.

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12 December 2020

CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo

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12 December 2020

Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels

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12 December 2020

In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury

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12 December 2020

Rnai as an experimental and therapeutic tool to study and regulate physiological and disease processes.

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12 December 2020

Nonviral genetic modification mediates effective transgene expression and functional RNA interference in human mesenchymal stem cells

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12 December 2020

Exploring RNA interference as a therapeutic strategy for renal disease.

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12 December 2020

10.1016/J.PHARMTHERA.2005.03.004

Identifiers

DOI

1 reference

24 July 2017

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