(Q40382781)

20 September 2017

title

Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma (English)

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20 September 2017

5

Michael P Manns

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20 September 2017

Meta W Djojosubroto

1

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20 September 2017

Allison C Chin

2

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20 September 2017

Ning Go

3

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20 September 2017

Sonja Schaetzlein

4

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20 September 2017

Sergei Gryaznov

6

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20 September 2017

Calvin B Harley

7

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20 September 2017

K Lenhard Rudolph

8

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20 September 2017

language of work or name

English

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publication date

1 November 2005

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20 September 2017

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20 September 2017

volume

42

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20 September 2017

issue

5

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20 September 2017

page(s)

1127-1136

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Double strand break metabolism and cancer susceptibility: lessons from the mre11 complex

20 September 2017

cites work

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Hepatocellular carcinoma: updates in primary prevention

21 January 2018

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7 January 2021

Human immunodeficiency virus and hepatitis C virus coinfection: epidemiology, natural history, therapeutic options and clinical management

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7 January 2021

Hepatocellular carcinoma

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7 January 2021

A survey of telomerase activity in human cancer

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7 January 2021

In situdetection of telomerase enzymatic activity in human hepatocellular carcinogenesis

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7 January 2021

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

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7 January 2021

Telomeres shorten during ageing of human fibroblasts

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7 January 2021

Telomere length predicts replicative capacity of human fibroblasts

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7 January 2021

The two-stage mechanism controlling cellular senescence and immortalization

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7 January 2021

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

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7 January 2021

Cellular senescence as a tumor-protection mechanism: the essential role of counting

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7 January 2021

Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells

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7 January 2021

Inhibition of telomerase activity by a distamycin derivative: effects on cell proliferation and induction of apoptosis in human cancer cells

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7 January 2021

Oligonucleotide N3'-->P5' phosphoramidates as efficient telomerase inhibitors

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7 January 2021

A highly selective telomerase inhibitor limiting human cancer cell proliferation

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7 January 2021

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

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7 January 2021

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

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7 January 2021

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

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7 January 2021

Oligonucleotide N3' --> P5' thio-phosphoramidate telomerase template antagonists as potential anticancer agents.

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7 January 2021

Antitumor effects of specific telomerase inhibitor GRN163 in human glioblastoma xenografts

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7 January 2021

Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma

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7 January 2021

Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition

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7 January 2021

Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells

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7 January 2021

Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

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7 January 2021

Telomere length measurements using digital fluorescence microscopy

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7 January 2021

Measurement of telomere length in haematopoietic cells using in situ hybridization techniques

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7 January 2021

Megabase chromatin domains involved in DNA double-strand breaks in vivo

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7 January 2021

Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

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7 January 2021

A DNA damage checkpoint response in telomere-initiated senescence

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7 January 2021

Phosphorylation of H2AX at short telomeres in T cells and fibroblasts

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7 January 2021

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

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7 January 2021

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

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7 January 2021

The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo.

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7 January 2021

Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen

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7 January 2021

Telomerase inhibition as cancer therapy.

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7 January 2021

Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma

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7 January 2021

Telomeres and telomerase: a dual role in hepatocarcinogenesis

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7 January 2021

Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma.

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7 January 2021

Identifiers

DOI

10.1002/HEP.20822

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20 September 2017

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