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The mTOR pathway negatively controls ATM by up-regulating miRNAs.
scientific article published on July 2013
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3718104
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4 March 2020
title
The mTOR pathway negatively controls ATM by up-regulating miRNAs
(English)
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PMC publication ID
3718104
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4 March 2020
author
Changxian Shen
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1
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3718104
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4 March 2020
author name string
Peter J Houghton
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2
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3718104
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4 March 2020
language of work or name
English
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publication date
1 July 2013
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4 March 2020
published in
Proceedings of the National Academy of Sciences of the United States of America
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3718104
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4 March 2020
volume
110
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Europe PubMed Central
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3718104
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4 March 2020
issue
29
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Europe PubMed Central
PMC publication ID
3718104
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23818585%20AND%20SRC:MED&resulttype=core&format=json
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4 March 2020
page(s)
11869-11874
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Europe PubMed Central
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3718104
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4 March 2020
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miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase.
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mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.
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Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation
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9 September 2017
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ATM is down-regulated by N-Myc-regulated microRNA-421.
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Mutational heterogeneity in human cancers: origin and consequences.
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microRNA profiling identifies cancer-specific and prognostic signatures in pediatric malignancies.
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Blinded by the Light: The Growing Complexity of p53
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9 September 2017
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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
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9 September 2017
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
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9 September 2017
Tel2 regulates the stability of PI3K-related protein kinases
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9 September 2017
p53 in health and disease
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9 September 2017
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Ras, PI(3)K and mTOR signalling controls tumour cell growth
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9 September 2017
The ATM/p53 pathway is commonly targeted for inactivation in squamous cell carcinoma of the head and neck (SCCHN) by multiple molecular mechanisms
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9 September 2017
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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
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9 September 2017
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
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PubMed Central
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Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J
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29 September 2017
Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
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29 September 2017
Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program.
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29 September 2017
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
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MYCN expression in human rhabdomyosarcoma cell lines and tumour samples
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https://pubmed.ncbi.nlm.nih.gov/23818585
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ataxia-telangiectasia-mutated (ATM) gene in head and neck squamous cell carcinoma: promoter hypermethylation with clinical correlation in 100 cases
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23818585
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
N-myc gene is amplified in alveolar rhabdomyosarcomas (RMS) but not in embryonal RMS
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23818585
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1073/PNAS.1220898110
1 reference
stated in
Europe PubMed Central
PMC publication ID
3718104
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23818585%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
ADS bibcode
2013PNAS..11011869S
0 references
PMC publication ID
3718104
1 reference
stated in
Europe PubMed Central
PMC publication ID
3718104
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23818585%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
PubMed publication ID
23818585
1 reference
stated in
Europe PubMed Central
PMC publication ID
3718104
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23818585%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
ResearchGate publication ID
244482638
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