(Q37055527)

18 August 2017

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival (English)

1 reference

18 August 2017

Sam D Molyneux

9

0 references

Purna A Joshi

Purna A Joshi

7

0 references

Dirk Brenner

Dirk Brenner

16

0 references

Rama Khokha

Rama Khokha

20

0 references

Andrew Wakeham

8

Andrew Wakeham

1 reference

18 August 2017

22

Tak W Mak

1 reference

18 August 2017

12

David W Cescon

1 reference

18 August 2017

4

Jennifer Silvester

1 reference

18 August 2017

23

Mona L Gauthier

1 reference

18 August 2017

19

Hal K Berman

1 reference

18 August 2017

17

Alan Tseng

1 reference

18 August 2017

1

Chiara Gorrini

1 reference

18 August 2017

Pegah S Baniasadi

2

1 reference

18 August 2017

Isaac S Harris

3

1 reference

18 August 2017

Satoshi Inoue

5

1 reference

18 August 2017

Bryan Snow

6

1 reference

18 August 2017

Bernard Martin

10

1 reference

18 August 2017

Peter Bouwman

11

1 reference

18 August 2017

Andrew J Elia

13

1 reference

18 August 2017

Zoe Winterton-Perks

14

1 reference

18 August 2017

Jennifer Cruickshank

15

1 reference

18 August 2017

Melinda Musgrave

18

1 reference

18 August 2017

Jos Jonkers

21

1 reference

18 August 2017

language of work or name

English

0 references

publication date

15 July 2013

1 reference

Journal of Experimental Medicine

18 August 2017

1 reference

18 August 2017

210

1 reference

18 August 2017

8

1 reference

18 August 2017

1529-1544

1 reference

describes a project that uses

18 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3727320/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Aberrant Keap1 methylation in breast cancer and association with clinicopathological features

29 September 2017

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The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-like breast cancer

29 September 2017

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29 September 2017

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Tumor suppressor genes and ROS: complex networks of interactions

29 September 2017

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Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155

29 September 2017

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BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.

29 September 2017

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

29 September 2017

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

29 September 2017

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Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells

29 September 2017

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MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism

29 September 2017

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Detoxification: a novel function of BRCA1 in tumor suppression?

29 September 2017

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Regulation of cancer cell metabolism

29 September 2017

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Triple-Negative Breast Cancer

29 September 2017

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Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics

29 September 2017

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Susceptibility pathways in Fanconi's anemia and breast cancer

29 September 2017

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

29 September 2017

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53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

29 September 2017

1 reference

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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

29 September 2017

1 reference

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Preclinical mouse models for BRCA1-associated breast cancer

29 September 2017

1 reference

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Nrf2: friend or foe for chemoprevention?

29 September 2017

1 reference

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A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

29 September 2017

1 reference

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Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

29 September 2017

1 reference

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Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Mitochondrial glutathione, a key survival antioxidant

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

BRCA1 down-regulates cellular levels of reactive oxygen species

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Loss of BRCA1 function increases the antitumor activity of cisplatin against human breast cancer xenografts in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Association of reactive oxygen species levels and radioresistance in cancer stem cells

29 September 2017

1 reference

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Molecular mechanisms of Nrf2-mediated antioxidant response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Re-evaluation of mammary stem cell biology based on in vivo transplantation

29 September 2017

1 reference

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Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

29 September 2017

1 reference

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Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumors

29 September 2017

1 reference

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A global double-fluorescent Cre reporter mouse

29 September 2017

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A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation

29 September 2017

1 reference

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Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

29 September 2017

1 reference

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The consensus coding sequences of human breast and colorectal cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Generation of a functional mammary gland from a single stem cell

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Purification and unique properties of mammary epithelial stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

BRCA1 induces antioxidant gene expression and resistance to oxidative stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

BRCA1 and BRCA2: 1994 and beyond

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Gene expression profiling predicts clinical outcome of breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Estrogens and cell-cycle regulation in breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Genetic analysis of BRCA1 function in a defined tumor cell line

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Biologic and pharmacologic regulation of mammalian glutathione synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Progesterone induces adult mammary stem cell expansion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Subtypes of familial breast tumours revealed by expression and copy number profiling

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Vitamin E analogue Trolox C. E.s.r. and pulse-radiolysis studies of free-radical reactions

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Mechanism of estrogen activation of c-myc oncogene expression

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727320

Gene expression profiling and its utility in prediction of local relapse after breast-conserving therapy in early breast cancer

4 September 2018

1 reference

12 December 2020

HSCs: stressing out over ROS

1 reference

12 December 2020

The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients

1 reference

12 December 2020

Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach

1 reference

12 December 2020

BRCA1—sowing the seeds crooked in the furrow

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20121337

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

23857982

1 reference