(Q37056618)

English

The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents

scientific article published on November 1, 2003

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents (English)

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

1 reference

based on heuristic

inferred from title

DNA mismatch repair

1 reference

based on heuristic

inferred from title

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

Daphne Haas-Kogan

4

object named as

Daphne A Haas-Kogan

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

3

object named as

David Stokoe

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

1

object named as

Yuichi Hirose

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14585987

26 March 2024

author name string

Makoto Katayama

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Daphne A. Haas-Kogan

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14585987

26 March 2024

Mitchel S. Berger

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14585987

26 March 2024

Russell O. Pieper

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14585987

26 March 2024

language of work or name

0 references

publication date

1 November 2003

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

full work available at URL

https://europepmc.org/articles/pmc262371?pdf=render

Portable Document Format

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14585987

26 March 2024

https://europepmc.org/articles/PMC262371

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14585987

26 March 2024

https://europepmc.org/articles/PMC262371?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14585987

26 March 2024

https://doi.org/10.1128/mcb.23.22.8306-8315.2003

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14585987

26 March 2024

https://journals.asm.org/doi/pdf/10.1128/MCB.23.22.8306-8315.2003

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

https://www.tandfonline.com/doi/pdf/10.1128/MCB.23.22.8306-8315.2003

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

Molecular and Cellular Biology

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

23

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

22

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

8306-8315

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

DNA repair and tumorigenesis: lessons from hereditary cancer syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

The mismatch repair system is required for S-phase checkpoint activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Current and future developments in the use of temozolomide for the treatment of brain tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Functional interactions and signaling properties of mammalian DNA mismatch repair proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Future directions in the treatment of malignant gliomas with temozolomide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Temozolomide in malignant gliomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Cell cycle regulation by the Cdc25 phosphatase family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

The p38 signal transduction pathway: activation and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Tetrazepinones are equally cytotoxic to Mer+ and Mer- human tumor cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Microsatellite instability and mutation of DNA mismatch repair genes in gliomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents

1 reference

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29 September 2017

Self-destruction and tolerance in resistance of mammalian cells to alkylation damage

1 reference

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29 September 2017

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation

1 reference

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29 September 2017

DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines

1 reference

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29 September 2017

Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

29 September 2017

Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

27 June 2018

ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

4 September 2018

Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

4 September 2018

Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

4 September 2018

p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262371

4 September 2018

Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene.

1 reference

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4 September 2018

Involvement of the mismatch repair system in temozolomide-induced apoptosis

1 reference

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4 September 2018

O6-methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics.

1 reference

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4 September 2018

Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: studies with blasts of leukaemic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mismatch correction at O 6 -methylguanine residues in E. coli DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and properties of O6-methylguanine-DNA transmethylase from rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer Research

6

55

2304

author name string

Branch P.

publication date

1995

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

Cancer Research

21

55

3721

author name string

Hawn M. T.

publication date

1995

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

Cancer Research

23

61

1957

author name string

Hirose Y.

publication date

2001

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

Cancer Research

24

61

5843

author name string

Hirose Y.

publication date

2001

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

Journal of Pharmacology and Experimental Therapeutics

27

288

484

author name string

Jean-Claude B. J.

publication date

1999

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

Cancer Research

33

54

4308

author name string

Koi M.

publication date

1994

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

Cancer Research

45

50

6119

author name string

Pegg A. E.

publication date

1990

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

Cancer Research

48

58

1068

author name string

Silber J. R.

publication date

1998

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

Cancer Research

49

61

4956

author name string

Sonoda Y.

publication date

2001

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

Cancer Research

50

47

5846

author name string

Stevens M. F. G.

publication date

1987

1 reference

10.1128/MCB.23.22.8306-8315.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8306-8315.2003

26 March 2024

Identifiers

10.1128/MCB.23.22.8306-8315.2003

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

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