(Q37064874)

18 August 2017

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title

Mitochondrial complex III regulates hypoxic activation of HIF. (English)

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18 August 2017

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T Klimova

1

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18 August 2017

N S Chandel

series ordinal

2

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18 August 2017

publication date

25 January 2008

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Cell Death & Differentiation

18 August 2017

published in

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18 August 2017

volume

15

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18 August 2017

issue

4

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18 August 2017

page(s)

660-666

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402307

18 August 2017

exact match

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cites work

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Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein

21 January 2018

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Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

21 January 2018

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

21 January 2018

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A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

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Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

21 January 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

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The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

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FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

21 January 2018

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Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

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Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

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Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells

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Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanisms

21 January 2018

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Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

21 January 2018

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Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

21 January 2018

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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

21 January 2018

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Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

21 January 2018

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Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

21 January 2018

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Mitochondrial regulation of oxygen sensing

21 January 2018

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21 January 2018

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The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2.

21 January 2018

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Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature.

21 January 2018

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Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

21 January 2018

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Complex III releases superoxide to both sides of the inner mitochondrial membrane

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

21 January 2018

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HIF-dependent antitumorigenic effect of antioxidants in vivo

21 January 2018

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JunD reduces tumor angiogenesis by protecting cells from oxidative stress

21 January 2018

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Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro

21 January 2018

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

21 January 2018

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HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

21 January 2018

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Intracellular diffusion gradients of O2 and ATP.

21 January 2018

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7 January 2021

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402307

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Dimensions Publication ID

18 August 2017

1037230255

0 references

1 reference