(Q37069448)

English

A combined bioinformatics and chemoinformatics approach for developing asymmetric bivalent AMPA receptor positive allosteric modulators as neuroprotective agents

scientific article published on 20 December 2012

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scholarly article

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Europe PubMed Central

PMC publication ID

18 August 2017

A combined bioinformatics and chemoinformatics approach for developing asymmetric bivalent AMPA receptor positive allosteric modulators as neuroprotective agents (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

cheminformatics

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1 reference

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author name string

Haijun Chen

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Cheng Z Wang

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Chunyong Ding

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Christopher Wild

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Bryan Copits

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Geoffrey T Swanson

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Kenneth M Johnson

7

1 reference

Europe PubMed Central

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18 August 2017

Jia Zhou

8

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Europe PubMed Central

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18 August 2017

language of work or name

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publication date

20 December 2012

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Europe PubMed Central

PMC publication ID

18 August 2017

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

8

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Europe PubMed Central

PMC publication ID

18 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

226-230

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

5-Arylbenzothiadiazine Type Compounds as Positive Allosteric Modulators of AMPA/Kainate Receptors

1 reference

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29 September 2017

Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties

1 reference

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Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes

1 reference

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29 September 2017

The Protein Data Bank at 40: reflecting on the past to prepare for the future

1 reference

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29 September 2017

Structural and Functional Analysis of Two New Positive Allosteric Modulators of GluA2 Desensitization and Deactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Probing the links between in vitro potency, ADMET and physicochemical parameters.

1 reference

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29 September 2017

Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Recent advances in the discovery of selective AMPA receptor positive allosteric modulators.

1 reference

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29 September 2017

Glutamate receptor ion channels: structure, regulation, and function

1 reference

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29 September 2017

Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator

1 reference

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29 September 2017

Current trends in antimicrobial agent research: chemo- and bioinformatics approaches

1 reference

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29 September 2017

Challenges for and current status of research into positive modulators of AMPA receptors.

1 reference

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29 September 2017

Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Molecular docking algorithms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

The Protein Data Bank (PDB), its related services and software tools as key components for in silico guided drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Limitations and lessons in the use of X-ray structural information in drug design

1 reference

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29 September 2017

In search of novel AMPA potentiators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Ketamine-induced neuronal cell death in the perinatal rhesus monkey

1 reference

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29 September 2017

Bridging chemical and biological space: "target fishing" using 2D and 3D molecular descriptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Recent advances in positive allosteric modulators of the AMPA receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Glutamate receptors at atomic resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Mechanism of positive allosteric modulators acting on AMPA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Exploring biology with small organic molecules

1 reference

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29 September 2017

Can the pharmaceutical industry reduce attrition rates?

1 reference

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29 September 2017

Pursuing the leadlikeness concept in pharmaceutical research.

1 reference

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29 September 2017

Key factors in the rising cost of new drug discovery and development

1 reference

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29 September 2017

Multiple molecular determinants for allosteric modulation of alternatively spliced AMPA receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Application and limitations of X-ray crystallographic data in structure-based ligand and drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

LY404187: a novel positive allosteric modulator of AMPA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Mechanism of glutamate receptor desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Chem-bioinformatics and QSAR: a review of QSAR lacking positive hydrophobic terms

1 reference

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29 September 2017

Rational drug discovery revisited: interfacing experimental programs with bio- and chemo-informatics

1 reference

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29 September 2017

Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

29 September 2017

Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3733225

4 September 2018

New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors

1 reference

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4 September 2018

The influence of drug-like concepts on decision-making in medicinal chemistry

1 reference

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4 September 2018

AMPA potentiator treatment of cognitive deficits in Alzheimer disease

1 reference

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4 September 2018

A combined bioinformatics and chemoinformatics approach for the development of new antiparasitic drugs.

1 reference

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4 September 2018

The role of caspase-3 activation in phencyclidine-induced neuronal death in postnatal rats

1 reference

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4 September 2018

Ampakines and the threefold path to cognitive enhancement

1 reference

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4 September 2018

Differential effects of acute and subchronic administration on phencyclidine-induced neurodegeneration in the perinatal rat.

1 reference

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4 September 2018

Role of caspase-3 in ethanol-induced developmental neurodegeneration

1 reference

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4 September 2018

Pronounced cell death in the absence of NMDA receptors in the developing somatosensory thalamus.

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4 September 2018

Developmental neurotoxicity of ketamine: morphometric confirmation, exposure parameters, and multiple fluorescent labeling of apoptotic neurons

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4 September 2018

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1 reference

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4 September 2018

Ethanol-induced caspase-3 activation in the in vivo developing mouse brain

1 reference

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4 September 2018

Blockade of the NMDA receptor increases developmental apoptotic elimination of granule neurons and activates caspases in the rat cerebellum.

1 reference

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4 September 2018

Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain

1 reference

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4 September 2018

Anwendung und Grenzen kristallographischer Daten im strukturbezogenen Liganden- und Wirkstoff-Design

1 reference

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

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21 January 2018

Chemical space and biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281122

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Finding the sweet spot: the role of nature and nurture in medicinal chemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/23281122

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY404187: A Novel Positive Allosteric Modulator of AMPA Receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200554

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CMDC.201200554

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

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