(Q37069535)

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Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain

scientific article published on December 2008

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scholarly article

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Europe PubMed Central

PMC publication ID

18 August 2017

Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

7

object named as

Neil Osheroff

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Anni H Andersen

6

object named as

Anni H Andersen

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

author name string

A Kathleen McClendon

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Amanda C Gentry

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Jennifer S Dickey

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Marie Brinch

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Simon Bendsen

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

language of work or name

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publication date

1 December 2008

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

47

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

50

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

13169-13178

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

DNA topoisomerase II, genotoxicity, and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Chirality sensing by Escherichia coli topoisomerase IV and the mechanism of type II topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Studies of a positive supercoiling machine. Nucleotide hydrolysis and a multifunctional "latch" in the mechanism of reverse gyrase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Cellular roles of dna topoisomerases: a molecular perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

DNA topoisomerases: structure, function, and mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Preferential relaxation of positively supercoiled DNA by E. coli topoisomerase IV in single-molecule and ensemble measurements.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Cellular distribution of mammalian DNA topoisomerase II is determined by its catalytically dispensable C-terminal domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Formation of topoisomerase II alpha complexes with nascent DNA is related to VM-26-induced cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

DNA topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Analysis of functional domain organization in DNA topoisomerase II from humans and Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Topoisomerase II: A specific marker for cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Casein kinase II phosphorylates the eukaryote-specific C-terminal domain of topoisomerase II in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Cytoplasmic localization of a mutant M(r) 160,000 topoisomerase II alpha is associated with the loss of putative bipartite nuclear localization signals in a drug-resistant human lung cancer cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

29 September 2017

Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

27 June 2018

Structure of DNA topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

27 June 2018

Bipartite nuclear localization signals in the C terminus of human topoisomerase II alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

27 June 2018

Topoisomerase IV can support oriC DNA replication in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

27 June 2018

Tandem regions of yeast DNA topoisomerase II share homology with different subunits of bacterial gyrase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

27 June 2018

Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

27 June 2018

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

27 June 2018

Structure of the Drosophila DNA topoisomerase II gene. Nucleotide sequence and homology among topoisomerases II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

27 June 2018

Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

27 June 2018

Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

4 September 2018

The structural basis for substrate specificity in DNA topoisomerase IV.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

4 September 2018

A superhelical spiral in the Escherichia coli DNA gyrase A C-terminal domain imparts unidirectional supercoiling bias.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

4 September 2018

The transducer domain is important for clamp operation in human DNA topoisomerase IIalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

4 September 2018

Topoisomerase II from Chlorella virus PBCV-1 has an exceptionally high DNA cleavage activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

4 September 2018

Topoisomerase II from Chlorella virus PBCV-1. Characterization of the smallest known type II topoisomerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

4 September 2018

Moving one DNA double helix through another by a type II DNA topoisomerase: the story of a simple molecular machine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

4 September 2018

Eukaryotic DNA topoisomerase II beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

4 September 2018

Human DNA topoisomerases II alpha and II beta can functionally substitute for yeast TOP2 in chromosome segregation and recombination.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

4 September 2018

Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. I. In vitro studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

4 September 2018

Serine 1524 is a major site of phosphorylation on human topoisomerase II alpha protein in vivo and is a substrate for casein kinase II in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2629653

4 September 2018

Antitumour drugs impede DNA uncoiling by topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/19053267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/19053267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topoisomerase II plays an essential role as a swivelase in the late stage of SV40 chromosome replication in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19053267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2 beta construct allows the study of topoisomerase II beta inhibitors in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/19053267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints

1 reference

https://pubmed.ncbi.nlm.nih.gov/19053267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigating the biological functions of DNA topoisomerases in eukaryotic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19053267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological regulation of eukaryotic topoisomerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/19053267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential mitotic functions of DNA topoisomerase IIalpha are not adopted by topoisomerase IIbeta in human H69 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19053267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the topoisomerase IV C-terminal domain: a broken beta-propeller implies a role as geometry facilitator in catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19053267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI800453H

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

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