(Q37070252)

18 August 2017

1 reference

title

Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. (English)

1 reference

18 August 2017

Hyun Lee

1

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18 August 2017

Peter L Whitfeld

series ordinal

2

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18 August 2017

Charles R Mackay

series ordinal

3

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18 August 2017

29 January 2008

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Immunology & Cell Biology

18 August 2017

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18 August 2017

86

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18 August 2017

2

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18 August 2017

153-160

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https://scigraph.springernature.com/pub.10.1038/sj.icb.7100166

18 August 2017

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cites work

Complement-targeted therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Generation of C5a in the absence of C3: a new complement activation pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Heteronuclear three-dimensional NMR spectroscopy of the inflammatory protein C5a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Function, structure and therapeutic potential of complement C5a receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Evaluation of the C-terminal C5a effector site with short synthetic C5a analog peptides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Structure-function relationships of human C5a and C5aR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5a-induced expression of P-selectin in endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Chemoattractant Receptors on Phagocytic Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5a delays apoptosis of human neutrophils via an extracellular signal-regulated kinase and Bad-mediated signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Degranulation from human eosinophils stimulated with C3a and C5a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Eosinophil leukocyte degranulation in response to serum-opsonized beads: C5a and platelet-activating factor enhance ECP release, with roles for protein kinases A and C

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Human plasmacytoid dendritic cells express receptors for anaphylatoxins C3a and C5a and are chemoattracted to C3a and C5a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5a-induced gene expression in human umbilical vein endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Expression of a functional C5a receptor in regenerating hepatocytes and its involvement in a proliferative signaling pathway in rat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Chemotaxis by a CNS macrophage, the microglia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5L2, a nonsignaling C5A binding protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

In vivo clearance and tissue distribution of C5a and C5a des arginine complement fragments in rabbits

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

The chemotactic receptor for human C5a anaphylatoxin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Identification of four novel human G protein-coupled receptors expressed in the brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Expression and function of C5a receptor in mouse microvascular endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Complement: a novel factor in basal and ischemia-induced neurogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Expression of the anaphylatoxin receptor C5aR (CD88) by human articular chondrocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Cultured human glomerular mesangial cells express the C5a receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Induction of anaphylatoxin C5a receptors in rat hepatocytes by lipopolysaccharide in vivo: mediation by interleukin-6 from Kupffer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Functions of anaphylatoxin C5a in rat liver: direct and indirect actions on nonparenchymal and parenchymal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5a receptor and thymocyte apoptosis in sepsis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5L2 is a functional receptor for acylation-stimulating protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Evidence for a functional role of the second C5a receptor C5L2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Purification of the active C5a receptor from human polymorphonuclear leukocytes as a receptor-Gi complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5L2--an anti-inflammatory molecule or a receptor for acylation stimulating protein (C3a-desArg)?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Mapping of the C5a receptor signal transduction network in human neutrophils

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): separate signals are required for activation and inactivation of paks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

The complement component C5a induces the expression of plasminogen activator inhibitor-1 in human macrophages via NF-kappaB activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinase-dependent inhibition of caspase 3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Understanding phospholipase D (PLD) using leukocytes: PLD involvement in cell adhesion and chemotaxis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Activation of several MAP kinases upon stimulation of rat alveolar macrophages: role of the NADPH oxidase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Role of C5a-C5aR interaction in sepsis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Multiple activation steps of the N-formyl peptide receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Complement-induced impairment of innate immunity during sepsis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Role of C5a in multiorgan failure during sepsis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Alteration of chemoattractant receptor expression regulates human neutrophil chemotaxis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Regulation by C5a of neutrophil activation during sepsis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Local production of complement proteins in rheumatoid arthritis synovium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Essential role for the C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Pathogenesis of rheumatoid arthritis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Complement in lung disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Complement in glomerulonephritis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Increased levels of plasma anaphylatoxins in systemic lupus erythematosus predict flares of the disease and may elicit vascular injury in lupus cerebritis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

The role of the complement system in ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Complement factors c3a, c4a, and c5a in chronic obstructive pulmonary disease and asthma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Enhanced expression of chemotactic receptors in multiple sclerosis lesions.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Complement component C5a predicts future cardiovascular events in patients with advanced atherosclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Effect of an anti-C5a monoclonal antibody indicates a prominent role for anaphylatoxin in pulmonary xenograft dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Complement C5a receptor antagonist attenuates multiple organ injury in a model of ruptured abdominal aortic aneurysm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Detrimental effects of complement activation in hemorrhagic shock

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Targeting C5a: recent advances in drug discovery.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Pharmacological characterization of antagonists of the C5a receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Discovery of human antibodies against the C5aR target using phage display technology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Protection of innate immunity by C5aR antagonist in septic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Blocking the receptor for C5a in patients with rheumatoid arthritis does not reduce synovial inflammation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Potent antibody therapeutics by design

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Selection, design, and engineering of therapeutic antibodies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Monoclonal antibody successes in the clinic

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

C5A anaphylatoxin and its seven transmembrane-segment receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Chimeric receptor analysis of the ketanserin binding site in the human 5-Hydroxytryptamine1D receptor: importance of the second extracellular loop and fifth transmembrane domain in antagonist binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Arthritis critically dependent on innate immune system players

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Gc-globulin concentrations and C5 haplotype-tagging polymorphisms contribute to variations in serum activity of complement factor C5.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Are cytokines involved in osteoarthritic pathophysiology?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

A review of current knowledge of the complement system and the therapeutic opportunities in inflammatory arthritis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100166

7 January 2021

Identifiers

DOI

10.1038/SJ.ICB.7100166

1 reference

Dimensions Publication ID

18 August 2017

0 references

1 reference