(Q37070256)

18 August 2017

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title

Too dangerous to ignore: self-tolerance and the control of ignorant autoreactive T cells (English)

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18 August 2017

Ian A Parish

1

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William R Heath

object named as

William R Heath

series ordinal

2

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publication date

29 January 2008

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Immunology & Cell Biology

18 August 2017

published in

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18 August 2017

volume

86

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18 August 2017

issue

2

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18 August 2017

page(s)

146-152

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Central tolerance: learning self-control in the thymus

18 August 2017

cites work

1 reference

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Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

21 January 2018

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T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity

21 January 2018

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

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Self-representation in the thymus: an extended view

21 January 2018

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The enemy within: keeping self-reactive T cells at bay in the periphery

21 January 2018

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T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus

21 January 2018

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Aire regulates negative selection of organ-specific T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Autoimmune diabetes as a consequence of locally produced interleukin-2

21 January 2018

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Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

21 January 2018

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Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

21 January 2018

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Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: precursor frequency, fine specificity, and cytotoxicity

21 January 2018

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Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein

21 January 2018

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T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects

21 January 2018

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Cytotoxic T cells to an epitope in the islet autoantigen IA-2 are not disease-specific

21 January 2018

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A new clinically relevant approach to expand myelin specific T cells.

21 January 2018

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Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction.

21 January 2018

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Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen

21 January 2018

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Peripheral tolerance of CD4 T cells following local activation in adolescent mice

21 January 2018

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Constitutive class I-restricted exogenous presentation of self antigens in vivo

21 January 2018

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Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells

21 January 2018

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CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

21 January 2018

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The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens

21 January 2018

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Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes

21 January 2018

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Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells

21 January 2018

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CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Conditions that induce tolerance in mature CD4+ T cells

21 January 2018

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Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells.

21 January 2018

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Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction

21 January 2018

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Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo

21 January 2018

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Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells

21 January 2018

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Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

21 January 2018

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Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection.

21 January 2018

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Chlamydia infections and heart disease linked through antigenic mimicry

21 January 2018

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Dendritic cells and the control of immunity

21 January 2018

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Innate immune recognition

21 January 2018

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Toll-like receptor control of the adaptive immune responses

21 January 2018

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Pathogen recognition and innate immunity

21 January 2018

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Natural adjuvants: endogenous activators of dendritic cells

21 January 2018

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Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses

21 January 2018

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Molecular identification of a danger signal that alerts the immune system to dying cells

21 January 2018

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Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

21 January 2018

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Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4.

21 January 2018

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Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Temporal development of autoreactive Th1 responses and endogenous presentation of self myelin epitopes by central nervous system-resident APCs in Theiler's virus-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Cell-Associated Ovalbumin Is Cross-Presented Much More Efficiently than Soluble Ovalbumin In Vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Immune tolerance after delivery of dying cells to dendritic cells in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Epitope spreading in immune-mediated diseases: implications for immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Toll-dependent selection of microbial antigens for presentation by dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

7 January 2021

Promiscuous thymic expression of an autoantigen gene does not result in negative selection of pathogenic T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

7 January 2021

Extrathymic acquisition of tolerance by T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

7 January 2021

T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

7 January 2021

Antigen-presenting cells in adoptively transferred and spontaneous autoimmune diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

7 January 2021

Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

7 January 2021

Stressed apoptotic tumor cells stimulate dendritic cells and induce specific cytotoxic T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

7 January 2021

Cutting edge: inflammatory signals drive organ-specific autoimmunity to normally cross-tolerizing endogenous antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

7 January 2021

Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigens

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100161

7 January 2021

Identifiers

DOI

10.1038/SJ.ICB.7100161

1 reference

18 August 2017

1 reference