(Q37076181)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json

cryogenic electron microscopy

5 March 2020

main subject

0 references

MCM DNA helicase complex subunit MCM4 YPR019W

1 reference

AAA family ATPase CDC6 YJL194W

GOA release 2020-03-11

1 reference

MCM DNA helicase complex subunit MCM2 YBL023C

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Alejandra Fernández-Cid

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Hironori Kawakami

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Bruce William Stillman

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Christian Speck

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

author name string

Jingchuan Sun

1

1 reference

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5 March 2020

Cecile Evrin

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Stefan A Samel

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Alberto Riera

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Huilin Li

9

1 reference

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5 March 2020

publication date

14 July 2013

1 reference

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Nature Structural & Molecular Biology

5 March 2020

published in

1 reference

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5 March 2020

volume

20

1 reference

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5 March 2020

issue

8

1 reference

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5 March 2020

page(s)

944-951

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json

The bacterial DnaC helicase loader is a DnaB ring breaker

5 March 2020

cites work

1 reference

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ATPase-dependent quality control of DNA replication origin licensing

29 September 2017

1 reference

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Structure and evolutionary origins of the CMG complex

29 September 2017

1 reference

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In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.

29 September 2017

1 reference

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DOLORS: versatile strategy for internal labeling and domain localization in electron microscopy

29 September 2017

1 reference

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The origin recognition complex: a biochemical and structural view

29 September 2017

1 reference

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ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.

29 September 2017

1 reference

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Cdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Complete subunit architecture of the proteasome regulatory particle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Structural insights into the Cdt1-mediated MCM2-7 chromatin loading.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Tilt-pair analysis of images from a range of different specimens in single-particle electron cryomicroscopy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

The structural basis for MCM2-7 helicase activation by GINS and Cdc45.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Cryo-EM of macromolecular assemblies at near-atomic resolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

The Mcm complex: unwinding the mechanism of a replicative helicase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Eukaryotic DNA replication control: lock and load, then fire

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Structure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Crystal structure of a near-full-length archaeal MCM: Functional insights for an AAA+ hexameric helicase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Single particle EM studies of the Drosophila melanogaster origin recognition complex and evidence for DNA wrapping

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Structure of the oligosaccharyl transferase complex at 12 A resolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Structural basis of DNA replication origin recognition by an ORC protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

EMAN2: an extensible image processing suite for electron microscopy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Clamp loaders and replication initiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Open clamp structure in the clamp-loading complex visualized by electron microscopic image analysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Origin recognition and the chromosome cycle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

UCSF Chimera--a visualization system for exploratory research and analysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Eukaryotic MCM proteins: beyond replication initiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Hexameric ring structure of the full-length archaeal MCM protein complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

The structure and function of MCM from archaeal M. Thermoautotrophicum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

DNA replication in eukaryotic cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

The DNA replication fork in eukaryotic cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3735830

Structure of DNase I at 2.0 Å resolution suggests a mechanism for binding to and cutting DNA

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNSMB.2629

21 January 2018

Identifiers

DOI

10.1038/NSMB.2629

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

23851460

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23851460%20AND%20SRC:MED&resulttype=core&format=json