(Q37079729)

18 August 2017

1 reference

title

Role and regulation of prolyl hydroxylase domain proteins (English)

1 reference

18 August 2017

G-H Fong

1

1 reference

PubMed ID

18259202

18 August 2017

K Takeda

series ordinal

2

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PubMed ID

18259202

18 August 2017

language of work or name

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15 February 2008

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Cell Death & Differentiation

18 August 2017

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18 August 2017

15

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18 August 2017

635-641

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18 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/cdd.2008.10

18 August 2017

0 references

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7 January 2021

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7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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7 January 2021

Signalling hypoxia by HIF hydroxylases

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7 January 2021

The Skp1 prolyl hydroxylase from Dictyostelium is related to the hypoxia-inducible factor-alpha class of animal prolyl 4-hydroxylases

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7 January 2021

An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha

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7 January 2021

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

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7 January 2021

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

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7 January 2021

Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro

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The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).

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Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

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Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

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Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

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Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

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Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

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Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for

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7 January 2021

Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product

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7 January 2021

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

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7 January 2021

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

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7 January 2021

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

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7 January 2021

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

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7 January 2021

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

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7 January 2021

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

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7 January 2021

Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues.

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7 January 2021

Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element

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7 January 2021

Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene

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7 January 2021

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation

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https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Analysis of the hypoxia-sensing pathway in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Expression of HIF prolyl hydroxylase isozymes in growth plate chondrocytes: relationship between maturation and apoptotic sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Prolyl-hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.10

7 January 2021

Identifiers

DOI

10.1038/CDD.2008.10

1 reference

18 August 2017

1 reference

PubMed ID

18259202