(Q37081728)

English

A novel small-molecule enantiomeric analogue of traditional (-)-morphinans has specific TLR9 antagonist properties and reduces sterile inflammation-induced organ damage

scientific article published on 15 March 2013

In more languages

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

A novel small-molecule enantiomeric analogue of traditional (-)-morphinans has specific TLR9 antagonist properties and reduces sterile inflammation-induced organ damage (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

toll-like receptor

0 references

1 reference

based on heuristic

inferred from title

author name string

Rafaz Hoque

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Ahmad Farooq

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Ahsan Malik

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Bobby N Trawick

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

David W Berberich

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Joseph P McClurg

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Karen P Galen

7

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Wajahat Mehal

8

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

language of work or name

0 references

publication date

15 March 2013

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Journal of Immunology

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

190

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

4297-4304

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

New developments in Toll-like receptor targeted therapeutics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Clodronate-containing liposomes attenuate lung injury in rats with severe acute pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

IFI16 is an innate immune sensor for intracellular DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

The immunostimulatory activity of unmethylated and methylated CpG oligodeoxynucleotide is dependent on their ability to colocalize with TLR9 in late endosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Homology modeling of human Toll-like receptors TLR7, 8, and 9 ligand-binding domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Oligodeoxyribonucleotide-based antagonists for Toll-like receptors 7 and 9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

TLR9-independent effects of inhibitory oligonucleotides on macrophage responses to S. typhimurium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Development of TLR inhibitors for the treatment of autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

How dying cells alert the immune system to danger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

A Toll-like receptor recognizes bacterial DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

29 September 2017

TLR9 is expressed in idiopathic interstitial pneumonia and its activation promotes in vitro myofibroblast differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

27 June 2018

Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3738054

3 September 2018

Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23509352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role of TLR9 in acute graft-versus-host disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23509352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23509352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9

1 reference

https://pubmed.ncbi.nlm.nih.gov/23509352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.1202184

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

0 references

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