(Q37088995)

English

Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras.

scientific article published on May 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras. (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

0 references

hepatocellular carcinoma

1 reference

based on heuristic

inferred from title

author name string

Scot R Kimball

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Ahmed Abbas

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Leonard S Jefferson

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

publication date

1 May 2008

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Journal of Pineal Research

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

44

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

379-386

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Reactive oxygen species-induced activation of the MAP kinase signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Oxidative stress and septic shock: metabolic aspects of oxygen-derived free radicals generated in the liver during endotoxemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Melatonin in Alzheimer's disease and other neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Diabetic neuropathy and oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Platelet-derived growth factor-induced p42/44 mitogen-activated protein kinase activation and cellular growth is mediated by reactive oxygen species in the absence of TSC2/tuberin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Rheb binds and regulates the mTOR kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

The role of oxidative stress in carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

TSC2: filling the GAP in the mTOR signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Apoptosis in primary lymphoid organs with aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Melatonin and cell death: differential actions on apoptosis in normal and cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

The chemistry of melatonin's interaction with reactive species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Ultraviolet-induced phosphorylation of p70(S6k) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase c

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Melatonin and circadian rhythms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Inhibition of androgen-sensitive LNCaP prostate cancer growth in vivo by melatonin: association of antiproliferative action of the pineal hormone with mt1 receptor protein expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Inhibition of malignant trophoblastic cell proliferation in vitro and in vivo by melatonin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

An essential role for free radicals and derived species in signal transduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

29 September 2017

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

27 June 2018

Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: beneficial effects of melatonin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-079X.2007.00539.X

21 January 2018

Early indicators of chronic lung disease in preterm infants with respiratory distress syndrome and their inhibition by melatonin.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-079X.2007.00539.X

21 January 2018

AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-079X.2007.00539.X

21 January 2018

Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-079X.2007.00539.X

21 January 2018

Melatonin modulates signal transduction pathways and apoptosis in experimental colitis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-079X.2007.00539.X

21 January 2018

Melatonin and prostate cancer cell proliferation: interplay with castration, epidermal growth factor, and androgen sensitivity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-079X.2007.00539.X

21 January 2018

Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-079X.2007.00539.X

21 January 2018

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-079X.2007.00539.X

21 January 2018

Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-079X.2007.00539.X

21 January 2018

Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-079X.2007.00539.X

21 January 2018

Melatonin as an antioxidant: physiology versus pharmacology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2638075

3 September 2018

Oxidative stress and heart failure

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-079X.2007.00539.X

21 January 2018

Prevention by melatonin of hepatocarcinogenesis in rats injected with N-nitrosodiethylamine

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-079X.2007.00539.X

21 January 2018

Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18410586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N(1)-acetyl-5-methoxykynuramine contrasts with other tryptophan metabolites by a peculiar type of NO scavenging: cyclization to a cinnolinone prevents formation of unstable nitrosamines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18410586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G

1 reference

https://pubmed.ncbi.nlm.nih.gov/18410586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18410586

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1600-079X.2007.00539.X

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

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