(Q37090120)

18 August 2017

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. (English)

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18 August 2017

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K Schroder

8

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John Silke

object named as

J Silke

11

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author name string

V Sagulenko

1

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18 August 2017

S J Thygesen

2

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18 August 2017

D P Sester

3

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18 August 2017

A Idris

4

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18 August 2017

J A Cridland

5

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18 August 2017

P R Vajjhala

6

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18 August 2017

T L Roberts

7

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18 August 2017

J E Vince

9

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18 August 2017

J M Hill

10

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18 August 2017

K J Stacey

12

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18 August 2017

3 May 2013

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Cell Death & Differentiation

18 August 2017

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18 August 2017

20

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18 August 2017

9

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18 August 2017

1149-1160

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https://scigraph.springernature.com/pub.10.1038/cdd.2013.37

18 August 2017

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Caspase-1-induced pyroptotic cell death

29 September 2017

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Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Activation of caspase-9, but not caspase-2 or caspase-8, is essential for heat-induced apoptosis in Jurkat cells

29 September 2017

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29 September 2017

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Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2.

29 September 2017

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Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.

29 September 2017

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Inflammatory caspases in innate immunity and inflammation

29 September 2017

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The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

29 September 2017

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

29 September 2017

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29 September 2017

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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

29 September 2017

1 reference

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Human caspases: activation, specificity, and regulation

29 September 2017

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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

29 September 2017

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

29 September 2017

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

29 September 2017

1 reference

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Pyroptosis: host cell death and inflammation

29 September 2017

1 reference

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HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

29 September 2017

1 reference

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Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers

29 September 2017

1 reference

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Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9

29 September 2017

1 reference

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Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages

29 September 2017

1 reference

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AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model

29 September 2017

1 reference

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Cryopyrin activates the inflammasome in response to toxins and ATP

29 September 2017

1 reference

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Gout-associated uric acid crystals activate the NALP3 inflammasome

29 September 2017

1 reference

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Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

29 September 2017

1 reference

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Caspase-8 serves both apoptotic and nonapoptotic roles

29 September 2017

1 reference

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

TMS1/ASC: the cancer connection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

The molecular basis for the lack of immunostimulatory activity of vertebrate DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Target protease specificity of the viral serpin CrmA. Analysis of five caspases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Electroporation and DNA-dependent cell death in murine macrophages

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741496

Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways

4 December 2018

1 reference

12 December 2020

CpG DNA Activates Survival in Murine Macrophages through TLR9 and the Phosphatidylinositol 3-Kinase-Akt Pathway

1 reference

12 December 2020

Pyrin N-terminal homology domain- and caspase recruitment domain-dependent oligomerization of ASC

1 reference

12 December 2020

Endotoxin-stimulated monocytes release multiple forms of IL-1 beta, including a proIL-1 beta form whose detection is affected by export

1 reference

12 December 2020

Caspase-9 is activated in a cytochrome c-independent manner early during TNFalpha-induced apoptosis in murine cells

1 reference

12 December 2020

Identifiers

DOI

10.1038/CDD.2013.37

1 reference

Dimensions Publication ID

18 August 2017

0 references

1 reference

18 August 2017

PubMed publication ID

23645208

1 reference