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A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers
scientific article published on 12 February 2009
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scholarly article
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Europe PubMed Central
PMCID
2647769
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19214186%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
title
A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers
(English)
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Europe PubMed Central
PMCID
2647769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19214186%20AND%20SRC:MED&resulttype=core&format=json
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21 January 2020
main subject
neural stem cell
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author
Barbara Stecca
series ordinal
1
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Europe PubMed Central
PMCID
2647769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19214186%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
author name string
Ariel Ruiz i Altaba
series ordinal
2
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Europe PubMed Central
PMCID
2647769
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19214186%20AND%20SRC:MED&resulttype=core&format=json
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21 January 2020
language of work or name
English
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publication date
12 February 2009
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2647769
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retrieved
21 January 2020
published in
The EMBO Journal
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Europe PubMed Central
PMCID
2647769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19214186%20AND%20SRC:MED&resulttype=core&format=json
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21 January 2020
volume
28
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Europe PubMed Central
PMCID
2647769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19214186%20AND%20SRC:MED&resulttype=core&format=json
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21 January 2020
issue
6
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stated in
Europe PubMed Central
PMCID
2647769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19214186%20AND%20SRC:MED&resulttype=core&format=json
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21 January 2020
page(s)
663-676
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Europe PubMed Central
PMCID
2647769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19214186%20AND%20SRC:MED&resulttype=core&format=json
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21 January 2020
cites work
Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
The Gli code: an information nexus regulating cell fate, stemness and cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Cancer and ageing: convergent and divergent mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Genetic pathways to primary and secondary glioblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Cooperative requirement of the Gli proteins in neurogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Isolation of neural stem cells from the postnatal cerebellum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
The p53 pathway: positive and negative feedback loops
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Characterization of the physical interaction of Gli proteins with SUFU proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Sequential actions of BMP receptors control neural precursor cell production and fate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Gli2 functions in FGF signaling during antero-posterior patterning
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Gli proteins encode context-dependent positive and negative functions: implications for development and disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Sonic hedgehog regulates the growth and patterning of the cerebellum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
14 September 2017
Altered neural cell fates and medulloblastoma in mouse patched mutants
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
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Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
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Control of the reversibility of cellular quiescence by the transcriptional repressor HES1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
29 September 2017
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
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Transplanted glioma cells migrate and proliferate on host brain vasculature: a dynamic analysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
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Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
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Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
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1 reference
stated in
PubMed Central
reference URL
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retrieved
27 June 2018
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1 reference
stated in
PubMed Central
reference URL
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retrieved
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1 reference
stated in
PubMed Central
reference URL
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retrieved
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reference URL
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retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
3 September 2018
p53 suppresses the self-renewal of adult neural stem cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
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1 reference
stated in
PubMed Central
reference URL
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3 September 2018
Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
3 September 2018
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
3 September 2018
GLI activates transcription through a herpes simplex viral protein 16-like activation domain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
3 September 2018
Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2647769
retrieved
3 September 2018
Identifiers
DOI
10.1038/EMBOJ.2009.16
1 reference
stated in
Europe PubMed Central
PMCID
2647769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19214186%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
PMCID
2647769
1 reference
stated in
Europe PubMed Central
PMCID
2647769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19214186%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
PubMed ID
19214186
1 reference
stated in
Europe PubMed Central
PMCID
2647769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19214186%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
ResearchGate publication ID
24005213
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