(Q37129790)

18 August 2017

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title

Structure/function relationships underlying regulation of FOXO transcription factors (English)

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18 August 2017

T Obsil

1

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18 August 2017

V Obsilova

series ordinal

2

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18 August 2017

language of work or name

English

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publication date

1 April 2008

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18 August 2017

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18 August 2017

volume

27

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18 August 2017

issue

16

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18 August 2017

page(s)

2263-2275

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https://scigraph.springernature.com/pub.10.1038/onc.2008.20

18 August 2017

exact match

0 references

cites work

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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

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Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily

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Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.

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C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span

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Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse

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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

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FoxO1a-cyclic GMP-dependent kinase I interactions orchestrate myoblast fusion

21 January 2018

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Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)

21 January 2018

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Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor Foxo4 are important for DNA binding

21 January 2018

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Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

21 January 2018

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

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Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways

21 January 2018

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Forkhead transcription factors: key players in development and metabolism

21 January 2018

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Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

21 January 2018

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Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

21 January 2018

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Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site

21 January 2018

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Nuclear targeting sequences--a consensus?

21 January 2018

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FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

21 January 2018

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Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes

21 January 2018

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14-3-3 proteins: structure, function, and regulation

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Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

21 January 2018

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21 January 2018

Winged helix proteins

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Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

21 January 2018

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FOXO transcription factors at the interface between longevity and tumor suppression

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.20

Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization

21 January 2018

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Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.20

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

21 January 2018

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CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage

21 January 2018

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Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

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Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function

21 January 2018

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Fox's in development and disease

21 January 2018

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A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.20

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

21 January 2018

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Crystal structure of the zeta isoform of the 14-3-3 protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.20

Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a)

21 January 2018

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Structural changes in the region directly adjacent to the DNA-binding helix highlight a possible mechanism to explain the observed changes in the sequence-specific binding of winged helix proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.20

Mammalian SIRT1 represses forkhead transcription factors

21 January 2018

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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.20

14-3-3 proteins: regulation of subcellular localization by molecular interference

21 January 2018

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Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.20

Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.20

14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.20

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

21 January 2018

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JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.20

The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Involvement of 14-3-3 proteins in nuclear localization of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Structure of the forkhead domain of FOXP2 bound to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

14-3-3 proteins; bringing new definitions to scaffolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

14-3-3 Isotypes facilitate coupling of protein kinase C-ζ to Raf-1: negative regulation by 14-3-3 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Stressing the role of FoxO proteins in lifespan and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

The fork head domain: a novel DNA binding motif of eukaryotic transcription factors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

FOXP3 controls regulatory T cell function through cooperation with NFAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.20

The structural basis for 14-3-3:phosphopeptide binding specificity

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.20

Nuclear localization of protein kinase U-alpha is regulated by 14-3-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Phylogenetic relationships of the Fox (Forkhead) gene family in the Bilateria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Bcr and Raf form a complex in vivo via 14-3-3 proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Backbone dynamics of a winged helix protein and its DNA complex at different temperatures: changes of internal motions in genesis upon binding to DNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Regulation of gene expression by insulin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

The dissociation rate of a winged helix protein-DNA complex is influenced by non-DNA contact residues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

Redox properties of cytochrome c nitrite reductase from Desulfovibrio desulfuricans ATCC 27774

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.20

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.20

1 reference

18 August 2017

1 reference