(Q47068907)

4 January 2018

title

C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span (English)

1 reference

4 January 2018

Forkhead box protein O CELE_R13H8.1

main subject

Caenorhabditis elegans

0 references

1 reference

Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1 CELE_R11A8.4

1 reference

14-3-3-like protein 2;14_3_3 domain-containing protein CELE_F52D10.3

1 reference

14-3-3-like protein 1;14_3_3 domain-containing protein CELE_M117.2

1 reference

1 reference

3

H Robert Horvitz

1 reference

4 January 2018

Leonard P. Guarente

series ordinal

4

object named as

Leonard Guarente

1 reference

4 January 2018

Ala Berdichevsky

series ordinal

1

object named as

Ala Berdichevsky

1 reference

4 January 2018

author name string

Mohan Viswanathan

series ordinal

2

1 reference

4 January 2018

language of work or name

English

0 references

publication date

1 June 2006

1 reference

4 January 2018

published in

Cell

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4 January 2018

volume

125

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4 January 2018

page(s)

1165-1177

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4 January 2018

issue

6

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4 January 2018

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1

cites work

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/citations/10.1074/JBC.M408748200

The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

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Genetic pathways that regulate ageing in model organisms

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FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Functional interaction between beta-catenin and FOXO in oxidative stress signaling

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Negative control of p53 by Sir2alpha promotes cell survival under stress

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

High-throughput isolation of Caenorhabditis elegans deletion mutants

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

The genetics of aging

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Mammalian SIRT1 represses forkhead transcription factors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

The unc-86 gene product couples cell lineage and cell identity in C. elegans

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

The Sir2 family of protein deacetylases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

The plasticity of aging: insights from long-lived mutants

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Mechanisms of life span determination in Caenorhabditis elegans

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

14-3-3 proteins; bringing new definitions to scaffolding

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Expression patterns and transcript processing of ftt-1 and ftt-2, two C. elegans 14-3-3 homologues.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Reverse genetics by chemical mutagenesis in Caenorhabditis elegans

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

DAF-16 target genes that control C. elegans life-span and metabolism.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Negative regulation of the forkhead transcription factor FKHR by Akt.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2006.04.036

Identifiers

DOI

10.1016/J.CELL.2006.04.036

1 reference

4 January 2018

PubMed ID

16777605

1 reference

4 January 2018