(Q37130148)

18 August 2017

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title

Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme (English)

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18 August 2017

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2

Wagner F Gattaz

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18 August 2017

Evelin L Schaeffer

1

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18 August 2017

publication date

19 February 2008

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18 August 2017

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18 August 2017

volume

198

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18 August 2017

issue

1

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18 August 2017

page(s)

1-27

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https://scigraph.springernature.com/pub.10.1007/s00213-008-1092-0

18 August 2017

exact match

0 references

cites work

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Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease

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Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD.

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Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

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Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease. A proton MR spectroscopic imaging and MRI study.

21 January 2018

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The expanding superfamily of phospholipase A(2) enzymes: classification and characterization

21 January 2018

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The decline in synapses and cholinergic activity is asynchronous in Alzheimer's disease.

21 January 2018

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Calcium-independent phospholipase A(2): structure and function.

21 January 2018

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A TrkA-to-p75NTR molecular switch activates amyloid beta-peptide generation during aging

21 January 2018

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12 December 2020

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

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12 December 2020

Biochemical and histochemical evidence of nonspecific binding of alpha7nAChR antibodies to mouse brain tissue

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12 December 2020

Critical duration of intracellular Ca2+ response required for continuous translocation and activation of cytosolic phospholipase A2.

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12 December 2020

Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease

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12 December 2020

[The neural basis of learning and memory declines in aged rats]

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12 December 2020

AMPA-selective glutamate receptor subtype immunoreactivity in the entorhinal cortex of non-demented elderly and patients with Alzheimer's disease.

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12 December 2020

Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain.

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12 December 2020

Glutamate receptors in the mammalian central nervous system

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12 December 2020

Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment.

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12 December 2020

Activation of m1 muscarinic acetylcholine receptor regulates tau phosphorylation in transfected PC12 cells

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12 December 2020

Decreased expression of N-methyl-D-aspartate receptor 1 messenger RNA in select regions of Alzheimer brain

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12 December 2020

Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat.

1 reference

12 December 2020

Astroglial expression of ceramide in Alzheimer's disease brains: a role during neuronal apoptosis.

1 reference

12 December 2020

Synthesis of acetylcholine from choline derived from phosphatidylcholine in a human neuronal cell line

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12 December 2020

Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study

1 reference

12 December 2020

Effect of lysophosphatidylcholine on transmembrane signal transduction

1 reference

12 December 2020

Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits

1 reference

12 December 2020

Modifications of neuronal phosphorylated tau immunoreactivity induced by NMDA toxicity

1 reference

12 December 2020

Long-lasting enhancement of ACh receptor currents by lysophospholipids.

1 reference

12 December 2020

Peripheral glutamate receptors: molecular biology and role in taste sensation

1 reference

12 December 2020

Distinct regulation of cytosolic phospholipase A2 phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes

1 reference

12 December 2020

Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons

1 reference

12 December 2020

Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2

1 reference

12 December 2020

Bidirectional modulation of AMPA receptor properties by exogenous phospholipase A2 in the hippocampus

1 reference

12 December 2020

Modulation of DL-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/quisqualate receptors by phospholipase A2 treatment.

1 reference

12 December 2020

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

12 December 2020

Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3beta inhibition and in neurons.

1 reference

12 December 2020

Selective loss of central cholinergic neurons in Alzheimer's disease

1 reference

12 December 2020

Interactions between arachidonic acid and metabotropic glutamate receptors in the induction of synaptic potentiation in the rat hippocampal slice

1 reference

12 December 2020

Effect of a subanesthetic dose of ketamine on memory and conscious awareness in healthy volunteers.

1 reference

12 December 2020

Comprehensive dissection of the medial temporal lobe in AD: measurement of hippocampus, amygdala, entorhinal, perirhinal and parahippocampal cortices using MRI.

1 reference

12 December 2020

The phospholipase A2 inhibitor bromophenacyl bromide prevents the depolarization-induced increase in [3H]AMPA binding in rat brain synaptoneurosomes

1 reference

12 December 2020

Cellular expression of alpha7 nicotinic acetylcholine receptor protein in the temporal cortex in Alzheimer's and Parkinson's disease--a stereological approach.

1 reference

12 December 2020

Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of Alzheimer's-disease-related changes

1 reference

12 December 2020

Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI.

1 reference

12 December 2020

Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory

1 reference

12 December 2020

Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration.

1 reference

12 December 2020

Opposing regulation of tau protein levels by ionotropic and metabotropic glutamate receptors in human NT2 neurons.

1 reference

12 December 2020

Arachidonic acid as a messenger for the expression of long-term potentiation.

1 reference

12 December 2020

Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective

1 reference

12 December 2020

Metabotropic glutamate receptors regulate APP processing in hippocampal neurons and cortical astrocytes derived from fetal rats.

1 reference

12 December 2020

Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer's disease

1 reference

12 December 2020

The relationship of membrane fluidity to growth and nuclear cycle in mitogen stimulated lymphocytes

1 reference

12 December 2020

Gene expression during memory formation.

1 reference

12 December 2020

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

1 reference

12 December 2020

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

1 reference

12 December 2020

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

1 reference

12 December 2020

Preservation of brain nerve growth factor in mild cognitive impairment and Alzheimer disease.

1 reference

12 December 2020

Changes of nuclear membrane lipid composition affect RNA nucleocytoplasmic transport

1 reference

12 December 2020

Prostaglandins stimulate calcium-dependent glutamate release in astrocytes.

1 reference

12 December 2020

Modulation of tau neuronal expression induced by NMDA, non-NMDA and metabotropic glutamate receptor agonists.

1 reference

12 December 2020

Oxidant-mediated AA release from astrocytes involves cPLA(2) and iPLA(2).

1 reference

12 December 2020

Human group IIA secretory phospholipase A2 potentiates Ca2+ influx through L‐type voltage‐sensitive Ca2+ channels in cultured rat cortical neurons

1 reference

12 December 2020

Effects of electrical stimulation and choline availability on the release and contents of acetylcholine and choline in superfused slices from rat striatum.

1 reference

12 December 2020

High sensitivity of glutamate uptake to extracellular free arachidonic acid levels in rat cortical synaptosomes and astrocytes.

1 reference

12 December 2020

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

1 reference

12 December 2020

Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease.

1 reference

12 December 2020

Reduction of choline acetyltransferase activity in primary visual cortex in mild to moderate Alzheimer's disease.

1 reference

12 December 2020

Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease

1 reference

12 December 2020

Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease.

1 reference

12 December 2020

Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease

1 reference

12 December 2020

Relationship between hippocampal volume and CA1 neuron loss in brains of humans with and without Alzheimer's disease

1 reference

12 December 2020

Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease

1 reference

12 December 2020

Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase

1 reference

12 December 2020

Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. II. Ageing, Korsakoff's disease, Parkinson's disease, and Alzheimer's disease

1 reference

12 December 2020

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

12 December 2020

Decreased phospholipase A2 activity in the brain and in platelets of patients with Alzheimer's disease.

1 reference

12 December 2020

Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices

1 reference

12 December 2020

Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry

1 reference

12 December 2020

Time-dependent increase in release of arachidonic acid following passive avoidance training in the day-old chick.

1 reference

12 December 2020

Phenotypic down-regulation of glutamate receptor subunit GluR1 in Alzheimer's disease

1 reference

12 December 2020

Decreased phospholipase A2 activity in Alzheimer brains.

1 reference

12 December 2020

Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}

1 reference

12 December 2020

Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain

1 reference

12 December 2020

Increase in arachidonic acid concentration in a postsynaptic membrane fraction following the induction of long-term potentiation in the dentate gyrus

1 reference

12 December 2020

Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s

1 reference

12 December 2020

The synergism between metabotropic glutamate receptor activation and arachidonic acid on glutamate release is occluded by induction of long-term potentiation in the dentate gyrus

1 reference

12 December 2020

Brain phospholipases A2: a perspective on the history

1 reference

12 December 2020

The C2 domain calcium-binding motif: structural and functional diversity

1 reference

12 December 2020

In vitro 31P NMR spectroscopy detects altered phospholipid metabolism in Alzheimer's disease

1 reference

12 December 2020

Biochemical aspects of neurodegeneration in human brain: involvement of neural membrane phospholipids and phospholipases A2.

1 reference

12 December 2020

Nicotine increases the expression of high affinity nerve growth factor receptors in both in vitro and in vivo

1 reference

12 December 2020

Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment

1 reference

12 December 2020

Molecular characterization of cytosolic phospholipase A2-beta

1 reference

12 December 2020

N-methyl-D-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease

1 reference

12 December 2020

Post-training cyclooxygenase-2 (COX-2) inhibition impairs memory consolidation

1 reference

12 December 2020

Chronic treatment with scopolamine and physostigmine changes nerve growth factor (NGF) receptor density and NGF content in rat brain

1 reference

12 December 2020

Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

1 reference

12 December 2020

Induction of cell death by endogenous nerve growth factor through its p75 receptor

1 reference

12 December 2020

Phospholipases A2 mediate amyloid-beta peptide-induced mitochondrial dysfunction.

1 reference

12 December 2020

Regional distribution, ontogeny, purification, and characterization of the Ca2+-independent phospholipase A2 from rat brain

1 reference

12 December 2020

Inhibitors of phospholipase A2 produce amnesia for a passive avoidance task in the chick.

1 reference

12 December 2020

Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A2.

1 reference

12 December 2020

Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease

1 reference

12 December 2020

Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release

1 reference

12 December 2020

Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease

1 reference

12 December 2020

The biological significance of plasmalogens in defense against oxidative damage

1 reference

12 December 2020

Cloning and recombinant expression of a structurally novel human secreted phospholipase A2

1 reference

12 December 2020

Hippocampus and entorhinal cortex in mild cognitive impairment and early AD

1 reference

12 December 2020

Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins

1 reference

12 December 2020

Modulation of the glutamate-evoked release of arachidonic acid from mouse cortical neurons: involvement of a pH-sensitive membrane phospholipase A2

1 reference

12 December 2020

"Autocannibalism" of membrane choline-phospholipids: physiology and pathology.

1 reference

12 December 2020

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

1 reference

12 December 2020

Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum

1 reference

12 December 2020

Nerve Growth Factor: Structure, Function and Therapeutic Implications for Alzheimers Disease

1 reference

12 December 2020

Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory

1 reference

12 December 2020

Differential regulation of molecular subtypes of muscarinic receptors in Alzheimer's disease.

1 reference

12 December 2020

Glutamate uptake in cultured astrocytes depends on age: a study about the effect of guanosine and the sensitivity to oxidative stress induced by H(2)O(2).

1 reference

12 December 2020

Enhancement by an ampakine of memory encoding in humans.

1 reference

12 December 2020

Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease

1 reference

12 December 2020

Alpha4beta2 nicotinic receptor status in Alzheimer's disease using 123I-5IA-85380 single-photon-emission computed tomography

1 reference

12 December 2020

Cytokines in neuroinflammation and Alzheimer's disease

1 reference

12 December 2020

The selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of Alzheimer disease.

1 reference

12 December 2020

Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw).

1 reference

12 December 2020

LTP occludes the interaction between arachidonic acid and ACPD and NGF and ACPD.

1 reference

12 December 2020

Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects

1 reference

12 December 2020

31P Nuclear Magnetic Resonance Study of the Brain in Alzheimerʼs Disease

1 reference

12 December 2020

Genes encoding multiple forms of phospholipase A2 are expressed in rat brain.

1 reference

12 December 2020

Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases.

1 reference

12 December 2020

Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of rat corpus striatum

1 reference

12 December 2020

Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia.

1 reference

12 December 2020

Arachidonic acid rescues hippocampal long-term potentiation blocked by group I metabotropic glutamate receptor antagonists

1 reference

12 December 2020

Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway

1 reference

12 December 2020

Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer's disease pathology

1 reference

12 December 2020

Ca2+-independent phospholipase A2 inhibitor impairs spatial memory of mice.

1 reference

12 December 2020

Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients

1 reference

12 December 2020

Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain

1 reference

12 December 2020

Magnetization transfer measurements of the hippocampus in the early diagnosis of Alzheimer's disease.

1 reference

12 December 2020

Increase in syntaxin 1B mRNA in hippocampal and cortical circuits during spatial learning reflects a mechanism of trans-synaptic plasticity involved in establishing a memory trace.

1 reference

12 December 2020

Post-training intrahippocampal infusion of the COX-2 inhibitor celecoxib impaired spatial memory retention in rats

1 reference

12 December 2020

31P magnetic resonance spectroscopy in Alzheimer's and Pick's disease.

1 reference

12 December 2020

The growing phospholipase A2 superfamily of signal transduction enzymes

1 reference

12 December 2020

Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer's disease brain

1 reference

12 December 2020

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

12 December 2020

Molecular insights into mechanisms of the cell death program: role in the progression of neurodegenerative disorders

1 reference

12 December 2020

Ceramide-1-phosphate activates cytosolic phospholipase A2alpha directly and by PKC pathway.

1 reference

12 December 2020

Phospholipase A2 modulates different subtypes of excitatory amino acid receptors: autoradiographic evidence.

1 reference

12 December 2020

Release of arachidonic acid by NMDA-receptor activation in the rat hippocampus

1 reference

12 December 2020

Spatial learning induces neurotrophin receptor and synapsin I in the hippocampus.

1 reference

12 December 2020

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.

1 reference

12 December 2020

An autoradiographic study of the organization of the efferet connections of the hippocampal formation in the rat

1 reference

12 December 2020

The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death

1 reference

12 December 2020

N-methyl-D-aspartate receptor density and membrane fluidity as possible determinants of the decline of passive avoidance performance in aging.

1 reference

12 December 2020

Is Alzheimer disease caused by lack of nerve growth factor?

1 reference

12 December 2020

Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms

1 reference

12 December 2020

31P nuclear magnetic resonance studies of phosphoglyceride metabolism in developing and degenerating brain: preliminary observations

1 reference

12 December 2020

Localization of cytosolic phospholipase A2 messenger RNA mainly in neurons in the rat brain.

1 reference

12 December 2020

Mediation by arachidonic acid metabolites of the H2O2-induced stimulation of mitogen-activated protein kinases (extracellular-signal-regulated kinase and c-Jun NH2-terminal kinase).

1 reference

12 December 2020

beta-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer's disease.

1 reference

12 December 2020

Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus

1 reference

12 December 2020

The cholinergic hypothesis of geriatric memory dysfunction

1 reference

12 December 2020

Alzheimer's disease, inflammation and non-steroidal anti-inflammatory drugs

1 reference

12 December 2020

Cytosolic PLA2: mRNA levels and potential for transcriptional regulation.

1 reference

12 December 2020

Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease

1 reference

12 December 2020

Muscarinic receptors mediate the release of arachidonic acid from spinal cord and hippocampal neurons in primary culture.

1 reference

12 December 2020

Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain.

1 reference

12 December 2020

Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type

1 reference

12 December 2020

Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus.

1 reference

12 December 2020

Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease

1 reference

12 December 2020

In vivo 1H MRS choline: correlation with in vitro chemistry/histology

1 reference

12 December 2020

A synaptic model of memory: long-term potentiation in the hippocampus

1 reference

12 December 2020

Effects of sialic acid and sialoglycoconjugates on cytosolic phospholipases A2 from bovine brain.

1 reference

12 December 2020

Independent folding and ligand specificity of the C2 calcium-dependent lipid binding domain of cytosolic phospholipase A2

1 reference

12 December 2020

Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T

1 reference

12 December 2020

N-methyl-d-aspartate receptor-mediated processing of beta-amyloid precursor protein in rat hippocampal slices: in vitro--superfusion study

1 reference

12 December 2020

Cytosolic phospholipase A2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid-beta peptide

1 reference

12 December 2020

N-Methyl-D-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease

1 reference

12 December 2020

Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation.

1 reference

12 December 2020

Long-term potentiation requires activation of calcium-independent phospholipase A2

1 reference

12 December 2020

Production of nerve growth factor by beta-amyloid-stimulated astrocytes induces p75NTR-dependent tau hyperphosphorylation in cultured hippocampal neurons.

1 reference

12 December 2020

Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease

1 reference

12 December 2020

Modulation of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/quisqualate receptors by phospholipase A2: a necessary step in long-term potentiation?

1 reference

12 December 2020

Effects of arachidonic acid on glutamate and gamma-aminobutyric acid uptake in primary cultures of rat cerebral cortical astrocytes and neurons.

1 reference

12 December 2020

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1 reference

12 December 2020

Phospholipase A2 activation influences the processing and secretion of the amyloid precursor protein

1 reference

12 December 2020

A non-amyloidogenic function of BACE-2 in the secretory pathway

1 reference

12 December 2020

Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction.

1 reference

12 December 2020

Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells

1 reference

12 December 2020

Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain

1 reference

12 December 2020

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

1 reference

12 December 2020

Role of group IIa and group V secretory phospholipases A(2) in the metabolism of lipoproteins. Substrate specificities of the enzymes and the regulation of their activities by sphingomyelin

1 reference

12 December 2020

Training in the Morris water maze occludes the synergism between ACPD and arachidonic acid on glutamate release in synaptosomes prepared from rat hippocampus.

1 reference

12 December 2020

Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans

1 reference

12 December 2020

Interferon-gamma increases neuronal death in response to amyloid-beta1-42.

1 reference

12 December 2020

Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation.

1 reference

12 December 2020

Cognitive and subjective acute dose effects of intramuscular ketamine in healthy adults

1 reference

12 December 2020

Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding.

1 reference

12 December 2020

Acute rise in the concentration of free cytoplasmic calcium leads to dephosphorylation of the microtubule-associated protein tau.

1 reference

12 December 2020

Inhibition of phospholipase A2 reduces neurite outgrowth and neuronal viability.

1 reference

12 December 2020

Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease

1 reference

12 December 2020

Potassium-induced long-term potentiation in area CA1 of the hippocampus involves phospholipase activation

1 reference

12 December 2020

Current concepts in mild cognitive impairment

1 reference

12 December 2020

Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis

1 reference

12 December 2020

Receptor-coupled amyloid precursor protein processing

1 reference

12 December 2020

p75 and TrkA receptor signaling independently regulate amyloid precursor protein mRNA expression, isoform composition, and protein secretion in PC12 cells

1 reference

12 December 2020

Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease.

1 reference

12 December 2020

Phospholipase A(2) isoforms: a perspective

1 reference

12 December 2020

Muscarinic control of amyloid precursor protein secretion in rat cerebral cortex and cerebellum.

1 reference

12 December 2020

Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease

1 reference

12 December 2020

A novel role for calcium-independent phospholipase A in alpha-amino-3-hydroxy-5-methylisoxazole-propionate receptor regulation during long-term potentiation.

1 reference

12 December 2020

Brain proton magnetic resonance spectroscopy in Alzheimer disease: changes after treatment with xanomeline

1 reference

12 December 2020

Phospholipase A2 is involved in muscarinic receptor-mediated sAPPalpha release independently of cyclooxygenase or lypoxygenase activity in SH-SY5Y cells

1 reference

12 December 2020

Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine

1 reference

12 December 2020

Arachidonic acid induces a long-lasting facilitation of hippocampal synaptic transmission by modulating PKC activity and nicotinic ACh receptors.

1 reference

12 December 2020

Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment

1 reference

12 December 2020

The role of arachidonic acid in the secretion of the amyloid precursor protein (APP).

1 reference

12 December 2020

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1 reference

12 December 2020

Effects of the M1 agonist xanomeline on processing of human beta-amyloid precursor protein (FAD, Swedish mutant) transfected into Chinese hamster ovary-m1 cells.

1 reference

12 December 2020

Neurotrophins induce death of hippocampal neurons via the p75 receptor

1 reference

12 December 2020

Experience-dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268.

1 reference

12 December 2020

High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.

1 reference

12 December 2020

Effect of amyloid peptides on the increase in TrkA receptor expression induced by nicotine in vitro and in vivo

1 reference

12 December 2020

Five-year retrospective changes in hippocampal atrophy and cognitive screening test performances in very mild Alzheimer's disease: the Tajiri Project.

1 reference

12 December 2020

Activation of the secretory pathway leads to a decrease in the intracellular amyloidogenic fragments generated from the amyloid protein precursor

1 reference

12 December 2020

Brain structure and task-specific increase in expression of the gene encoding syntaxin 1B during learning in the rat: a potential molecular marker for learning-induced synaptic plasticity in neural networks.

1 reference

12 December 2020

Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease

1 reference

12 December 2020

Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment.

1 reference

12 December 2020

Acute Effects of Ketamine on Memory Systems and Psychotic Symptoms in Healthy Volunteers

1 reference

12 December 2020

Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells

1 reference

12 December 2020

Memantine: a review of its use in Alzheimer's disease

1 reference

12 December 2020

Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: differential neuronal and astroglial pathology

1 reference

12 December 2020

Muscarinic cholinergic agonists stimulate arachidonic acid release from mouse striatal neurons in primary culture.

1 reference

12 December 2020

Reduced phospholipid breakdown in Alzheimer's brains: a 31P spectroscopy study.

1 reference

12 December 2020

Normal β-NGF content in Alzheimer's disease cerebral cortex and hippocampus

1 reference

12 December 2020

Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer's neuropathology.

1 reference

12 December 2020

NMDA receptors activate the arachidonic acid cascade system in striatal neurons

1 reference

12 December 2020

Inhibitors of Cyclooxygenases produce Amnesia for a Passive Avoidance Task in the Chick

1 reference

12 December 2020

Impairment of specific episodic memory processes by sub-psychotic doses of ketamine: the effects of levels of processing at encoding and of the subsequent retrieval task

1 reference

12 December 2020

The differential regulation of group II(A) and group V low molecular weight phospholipases A(2) in cultured rat astrocytes

1 reference

12 December 2020

The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2)

1 reference

12 December 2020

A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2

1 reference

12 December 2020

Molecular cloning of rat cDNA for cytosolic phospholipase A2 and the increased gene expression in the dentate gyrus following transient forebrain ischemia

1 reference

12 December 2020

Longitudinal evaluation of both morphologic and functional changes in the same individuals with Alzheimer's disease.

1 reference

12 December 2020

Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage

1 reference

12 December 2020

Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation

1 reference

12 December 2020

Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.

1 reference

12 December 2020

Evidence for a role of the nerve growth factor receptor TrkA in tyrosine phosphorylation and processing of beta-APP.

1 reference

12 December 2020

Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain.

1 reference

12 December 2020

Intrahippocampal infusion of a cyclooxygenase-2 inhibitor attenuates memory acquisition in rats.

1 reference

12 December 2020

Alzheimer's disease: changes in hippocampal N-methyl-D-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors--an autoradiographic study.

1 reference

12 December 2020

The loss of GluR2(3) immunoreactivity precedes neurofibrillary tangle formation in the entorhinal cortex and hippocampus of Alzheimer brains.

1 reference

12 December 2020

Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

1 reference

12 December 2020

Arachidonic acid inhibits uptake of glutamate and glutamine but not of GABA in cultured cerebellar granule cells.

1 reference

12 December 2020

Repeated nicotine exposure in rats: effects on memory function, cholinergic markers and nerve growth factor.

1 reference

12 December 2020

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling.

1 reference

12 December 2020

Glutamate-stimulated secretion of amyloid precursor protein from cortical rat brain slices

1 reference

12 December 2020

Relations between hypometabolism in the posterior association neocortex and hippocampal atrophy in Alzheimer's disease: a PET/MRI correlative study

1 reference

12 December 2020

Verbal episodic memory impairment in Alzheimer's disease: a combined structural and functional MRI study.

1 reference

12 December 2020

High selective expression of alpha7 nicotinic receptors on astrocytes in the brains of patients with sporadic Alzheimer's disease and patients carrying Swedish APP 670/671 mutation: a possible association with neuritic plaques.

1 reference

12 December 2020

Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices.

1 reference

12 December 2020

Efficacy of xanomeline in Alzheimer disease: cognitive improvement measured using the Computerized Neuropsychological Test Battery (CNTB).

1 reference

12 December 2020

Cholinergic markers in elderly patients with early signs of Alzheimer disease.

1 reference

12 December 2020

Alzheimer's disease is associated with a selective increase in alpha7 nicotinic acetylcholine receptor immunoreactivity in astrocytes

1 reference

12 December 2020

Inflammation and neurodegenerative diseases

1 reference

12 December 2020

Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2

1 reference

12 December 2020

Volumes of medial temporal lobe structures in patients with Alzheimer's disease and mild cognitive impairment (and in healthy controls).

1 reference

12 December 2020

Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity

1 reference

12 December 2020

Requirement of hippocampal phospholipase A2 activity for long-term memory retrieval in rats.

1 reference

12 December 2020

AMPA receptor potentiators for the treatment of CNS disorders

1 reference

12 December 2020

Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain.

1 reference

12 December 2020

Simultaneous changes in secretory amyloid precursor protein and β-amyloid peptide release from rat hippocampus by activation of muscarinic receptors

1 reference

12 December 2020

Aging, amyloid, and Alzheimer's disease: a perspective in honor of Carl Cotman

1 reference

12 December 2020

Potentiation of NMDA receptor currents by arachidonic acid

1 reference

12 December 2020

Melittin increases AMPA receptor affinity in rat brain synaptoneurosomes.

1 reference

12 December 2020

Plasma membrane ordering agent pluronic F-68 (PF-68) reduces neurotransmitter uptake and release and produces learning and memory deficits in rats

1 reference

12 December 2020

Modulation of phospholipase A2 activity in primary cultures of rat cortical neurons

1 reference

12 December 2020

Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment.

1 reference

12 December 2020

Declarative memory impairments in Alzheimer's disease and semantic dementia

1 reference

12 December 2020

A frontal variant of Alzheimer's disease exhibits decreased calcium-independent phospholipase A2 activity in the prefrontal cortex

1 reference

12 December 2020

Inhibitors of PLA2 and NO synthase cooperate in producing amnesia of a spatial task.

1 reference

12 December 2020

Reduction of AMPA-selective glutamate receptor subunits in the entorhinal cortex of patients with Alzheimer's disease pathology: a biochemical study.

1 reference

12 December 2020

Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease

1 reference

12 December 2020

Spatial learning induced changes in expression of the ryanodine type II receptor in the rat hippocampus.

1 reference

12 December 2020

Prostaglandin E2 production in astrocytes: regulation by cytokines, extracellular ATP, and oxidative agents.

1 reference

12 December 2020

A novel intracellular membrane-bound calcium-independent phospholipase A(2)

1 reference

12 December 2020

Inhibition of phospholipase A2 activity reduces membrane fluidity in rat hippocampus

1 reference

12 December 2020

AMPA/kainate receptor gene expression in normal and Alzheimer's disease hippocampus

1 reference

12 December 2020

Differential induction of c-Jun and Fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasks.

1 reference

12 December 2020

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

1 reference

12 December 2020

Amyloid precursor protein secretion via muscarinic receptors: reduced desensitization using the M1-selective agonist AF102B

1 reference

12 December 2020

Opposite effects of phospholipase A2 on [3H]AMPA binding in adult and neonatal membranes

1 reference

12 December 2020

Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis.

1 reference

12 December 2020

NMDA receptor-mediated arachidonic acid release in neurons: role in signal transduction and pathological aspects

1 reference

12 December 2020

Diversity of group types, regulation, and function of phospholipase A2

1 reference

12 December 2020

Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans.

1 reference

12 December 2020

Retrieval of memory for fear-motivated training initiates extinction requiring protein synthesis in the rat hippocampus

1 reference

12 December 2020

Phospholipase A2-induced changes in AMPA receptor: an autoradiographic study

1 reference

12 December 2020

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes.

1 reference

12 December 2020

Alterations in glutamate receptor 2/3 subunits and amyloid precursor protein expression during the course of Alzheimer's disease and Lewy body variant

1 reference

12 December 2020

Sphingolipids in mammalian cell signalling

1 reference

12 December 2020

Phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugly

1 reference

12 December 2020

CNS localization of neuronal nicotinic receptors.

1 reference

12 December 2020

The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from Chinese hamster ovary-m1 cells

1 reference

12 December 2020

Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2

1 reference

12 December 2020

Cerebral muscarinic acetylcholinergic receptor measurement in Alzheimer's disease patients on 11C-N-methyl-4-piperidyl benzilate--comparison with cerebral blood flow and cerebral glucose metabolism.

1 reference

12 December 2020

Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease.

1 reference

12 December 2020

Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs

1 reference

12 December 2020

Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors

1 reference

12 December 2020

Loss of high-affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: implications for the failure of cholinergic replacement therapies.

1 reference

12 December 2020

Task-specific enhancement of short-term, but not long-term, memory by class I metabotropic glutamate receptor antagonist 1-aminoindan-1,5-dicarboxylic acid in rats.

1 reference

12 December 2020

Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease

1 reference

12 December 2020

Phosphatidylcholine as a precursor of choline for acetylcholine synthesis

1 reference

12 December 2020

Effect of NC-1900, an active fragment analog of arginine vasopressin, and inhibitors of arachidonic acid metabolism on performance of a passive avoidance task in mice.

1 reference

12 December 2020

Blockade of ionotropic glutamate receptors produces neuronal apoptosis through the Bax-cytochrome C-caspase pathway: the causative role of Ca2+ deficiency

1 reference

12 December 2020

Phospholipid-metabolizing enzymes in Alzheimer's disease: increased lysophospholipid acyltransferase activity and decreased phospholipase A2 activity.

1 reference

12 December 2020

Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice.

1 reference

12 December 2020

Influence of nuclear membrane lipid fluidity on nuclear RNA release

1 reference

12 December 2020

Quantitative in vivo 31P magnetic resonance spectroscopy of Alzheimer disease.

1 reference

12 December 2020

The three-dimensional organization of the hippocampal formation: a review of anatomical data

1 reference

12 December 2020

Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus.

1 reference

12 December 2020

Immunohistochemical localization of nicotinic beta2 and alpha4 receptor subunits in normal human brain and individuals with Lewy body and Alzheimer's disease: preliminary observations.

1 reference

12 December 2020

Muscarinic cholinergic contribution to memory consolidation: with attention to involvement of the basolateral amygdala

1 reference

12 December 2020

Alteration of muscarinic receptor subtypes in CA1 field of hippocampus in senile dementia of Alzheimer type: an autoradiographic study.

1 reference

12 December 2020

N-methyl-D-aspartate receptor subunit NR2A and NR2B messenger RNA levels are altered in the hippocampus and entorhinal cortex in Alzheimer's disease

1 reference

12 December 2020

Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease.

1 reference

12 December 2020

Arachidonic acid potentiates currents through Ca2+-permeable AMPA receptors by interacting with a CaMKII pathway

1 reference

12 December 2020

Functions of ceramide in coordinating cellular responses to stress

1 reference

12 December 2020

Exposure to N-methyl-D-aspartate increases release of arachidonic acid in primary cultures of rat hippocampal neurons and not in astrocytes.

1 reference

12 December 2020

Constitutive activity of muscarinic acetylcholine receptors

1 reference

12 December 2020

Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases

1 reference

12 December 2020

Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling

1 reference

12 December 2020

Epibatidine and ABT 418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains.

1 reference

12 December 2020

The caveolin scaffolding domain modifies 2-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor binding properties by inhibiting phospholipase A2 activity

1 reference

12 December 2020

Correlation of regional proton magnetic resonance spectroscopic metabolic changes with cognitive deficits in mild Alzheimer disease

1 reference

12 December 2020

Abnormalities of hippocampal surface structure in very mild dementia of the Alzheimer type

1 reference

12 December 2020

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

1 reference

12 December 2020

In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease

1 reference

12 December 2020

Protein synthesis, PKA, and MAP kinase are differentially involved in short- and long-term memory in rats.

1 reference

12 December 2020

Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease

1 reference

12 December 2020

Effect of L-alpha glycerylphosphorylcholine on muscarinic receptors and membrane microviscosity of aged rat brain.

1 reference

12 December 2020

Mitogen-activated protein kinase is involved in N-methyl-D-aspartate receptor regulation of amyloid precursor protein cleavage

1 reference

12 December 2020

Prostaglandins play a role in memory consolidation in the chick.

1 reference

12 December 2020

Muscarinic acetylcholine receptor inhibition in transgenic Alzheimer-like Tg2576 mice by scopolamine favours the amyloidogenic route of processing of amyloid precursor protein

1 reference

12 December 2020

Inhibition of astrocyte glutamate uptake by reactive oxygen species: role of antioxidant enzymes.

1 reference

12 December 2020

Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins

1 reference

12 December 2020

Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease.

1 reference

12 December 2020

Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration.

1 reference

12 December 2020

Effect of subchronic treatment of memantine, galantamine, and nicotine in the brain of Tg2576 (APPswe) transgenic mice

1 reference

12 December 2020

The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene

1 reference

12 December 2020

Demonstration of a reduction in muscarinic receptor binding in early Alzheimer's disease using iodine-123 dexetimide single-photon emission tomography.

1 reference

12 December 2020

In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer's disease

1 reference

12 December 2020

Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation

1 reference

12 December 2020

Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias

1 reference

12 December 2020

Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients.

1 reference

12 December 2020

Reduced posterior cingulate binding of I-123 iodo-dexetimide to muscarinic receptors in mild Alzheimer's disease

1 reference

12 December 2020

Alterations of cerebral metabolism in probable Alzheimer's disease: a preliminary study.

1 reference

12 December 2020

Two time periods of hippocampal mRNA synthesis are required for memory consolidation of fear-motivated learning.

1 reference

12 December 2020

Free radicals and antioxidants in normal physiological functions and human disease

1 reference

12 December 2020

Interleukin-1 enhances the ATP-evoked release of arachidonic acid from mouse astrocytes.

1 reference

12 December 2020

Cortical NMDA receptor properties and membrane fluidity are altered in Alzheimer's disease.

1 reference

12 December 2020

Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease.

1 reference

12 December 2020

Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease.

1 reference

12 December 2020

Phospholipase A2 enzymes

1 reference

12 December 2020

Nicotinic receptors in dementia of Alzheimer, Lewy body and vascular types.

1 reference

12 December 2020

A study of the synergism between metabotropic glutamate receptor activation and arachidonic acid in the rat hippocampus

1 reference

12 December 2020

PET imaging of cortical 11C-nicotine binding correlates with the cognitive function of attention in Alzheimer's disease.

1 reference

12 December 2020

Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease.

1 reference

12 December 2020

10.1007/S00213-008-1092-0

Identifiers

DOI

1 reference

18 August 2017

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