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Flagellin as an adjuvant: cellular mechanisms and potential.
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Europe PubMed Central
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3756556
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048152%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
title
Flagellin as an adjuvant: cellular mechanisms and potential
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3756556
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048152%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
author
John T. Bates
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2
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Europe PubMed Central
PMCID
3756556
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048152%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
author name string
Steven B Mizel
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1
1 reference
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Europe PubMed Central
PMCID
3756556
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048152%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
language of work or name
English
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publication date
1 November 2010
1 reference
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Europe PubMed Central
PMCID
3756556
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048152%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
published in
Journal of Immunology
1 reference
stated in
Europe PubMed Central
PMCID
3756556
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048152%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
volume
185
1 reference
stated in
Europe PubMed Central
PMCID
3756556
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048152%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
issue
10
1 reference
stated in
Europe PubMed Central
PMCID
3756556
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048152%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
page(s)
5677-5682
1 reference
stated in
Europe PubMed Central
PMCID
3756556
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048152%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
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Superior efficacy of a recombinant flagellin:H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin.
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Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin
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Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates
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Incorporation of membrane-anchored flagellin into influenza virus-like particles enhances the breadth of immune responses.
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Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
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Mucosal adjuvant activity of flagellin in aged mice
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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
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Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis
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A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunity
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Cellular mechanisms of the adjuvant activity of the flagellin component FljB of Salmonella enterica Serovar Typhimurium to potentiate mucosal and systemic responses
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14 September 2017
Effects of flagellin on innate and adaptive immunity
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14 September 2017
The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node
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Mucosal administration of flagellin induces innate immunity in the mouse lung
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14 September 2017
Role of Toll-like receptors in costimulating cytotoxic T cell responses
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14 September 2017
Two nonadjacent regions in enteroaggregative Escherichia coli flagellin are required for activation of toll-like receptor 5.
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14 September 2017
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
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Activation of interleukin-1 receptor-associated kinase by gram-negative flagellin
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14 September 2017
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
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High-affinity interaction between gram-negative flagellin and a cell surface polypeptide results in human monocyte activation
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Evaluation of a truncated recombinant flagellin subunit vaccine against Campylobacter jejuni
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Induction of cytokine synthesis by flagella from gram-negative bacteria may be dependent on the activation or differentiation state of human monocytes
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Intranasal administration of synthetic recombinant peptide-based vaccine protects mice from infection by Schistosoma mansoni.
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14 September 2017
Salmonella flagellin induces tumor necrosis factor alpha in a human promonocytic cell line
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Activated human neonatal CD8+ T cells are subject to immunomodulation by direct TLR2 or TLR5 stimulation.
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Salmonella flagellin induces bystander activation of splenic dendritic cells and hinders bacterial replication in vivo.
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A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity
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Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity
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Gangliosides inhibit flagellin signaling in the absence of an effect on flagellin binding to toll-like receptor 5.
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Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitro
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Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses
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Gram-negative flagellin-induced self-tolerance is associated with a block in interleukin-1 receptor-associated kinase release from toll-like receptor 5.
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Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein
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Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium
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29 September 2017
TLR5 ligation by flagellin converts tolerogenic dendritic cells into activating antigen-presenting cells that preferentially induce T-helper 1 responses
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27 June 2018
Stimulation of human CD4⁺ T lymphocytes via TLR3, TLR5 and TLR7/8 up-regulates expression of costimulatory and modulates proliferation
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27 June 2018
Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions
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27 June 2018
Identification of a Sequence in Human Toll-like Receptor 5 Required for the Binding of Gram-negative Flagellin
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27 June 2018
Synthetic recombinant vaccine expressing influenza haemagglutinin epitope in Salmonella flagellin leads to partial protection in mice
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27 June 2018
Immunogenic properties of a recombinant fusion protein containing the C-terminal 19 kDa of Plasmodium falciparum merozoite surface protein-1 and the innate immunity agonist FliC flagellin of Salmonella typhimurium.
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3 September 2018
CD8+ T cell adjuvant effects of Salmonella FliCd flagellin in live vaccine vectors or as purified protein.
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3 September 2018
Immunization of young African green monkeys with OprF epitope 8-OprI-type A- and B-flagellin fusion proteins promotes the production of protective antibodies against nonmucoid Pseudomonas aeruginosa.
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3 September 2018
Immunoadjuvant capacity of flagellin and mannosamine-coated poly(anhydride) nanoparticles in oral vaccination.
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3 September 2018
A fusion protein vaccine containing OprF epitope 8, OprI, and type A and B flagellins promotes enhanced clearance of nonmucoid Pseudomonas aeruginosa.
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3 September 2018
IgA response of BALB/c mice to orally administered Salmonella typhimurium flagellin-displaying T2 bacteriophages
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3 September 2018
New malaria vaccine candidates based on the Plasmodium vivax Merozoite Surface Protein-1 and the TLR-5 agonist Salmonella Typhimurium FliC flagellin.
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3 September 2018
Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function
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3 September 2018
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
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3 September 2018
Inhibition of airway allergic disease by co-administration of flagellin with allergen
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3 September 2018
Bacterial flagellin inhibits T cell receptor-mediated activation of T cells by inducing suppressor of cytokine signalling-1 (SOCS-1).
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3 September 2018
Humoral immune response to flagellin requires T cells and activation of innate immunity
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3 September 2018
Immunogenicity of cholera toxin B epitope inserted in Salmonella flagellin expressed on bacteria and administered as DNA vaccine.
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3 September 2018
Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells.
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3 September 2018
Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1.
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3 September 2018
Mucosal immunization with purified flagellin from Salmonella induces systemic and mucosal immune responses in C3H/HeJ mice
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3 September 2018
Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response.
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3 September 2018
Human intestinal microvascular endothelial cells express Toll-like receptor 5: a binding partner for bacterial flagellin.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3756556
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3 September 2018
Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos.
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3 September 2018
A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells
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3 September 2018
Intranasal immunization with synthetic recombinant vaccine containing multiple epitopes of influenza virus
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3 September 2018
Antibody response against Escherichia coli heat-stable enterotoxin expressed as fusions to flagellin
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3 September 2018
Salmonella flagellin fused with a linear epitope of colonization factor antigen I (CFA/I) can prime antibody responses against homologous and heterologous fimbriae of enterotoxigenic Escherichia coli.
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3 September 2018
Intranasal administration of peptide vaccine protects human/mouse radiation chimera from influenza infection.
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3756556
retrieved
3 September 2018
Effect of pre-existing carrier immunity on the efficacy of synthetic influenza vaccine.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3756556
retrieved
3 September 2018
Synthetic recombinant influenza vaccine induces efficient long-term immunity and cross-strain protection.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3756556
retrieved
3 September 2018
Control of B-cell responses by Toll-like receptors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21048152
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21048152
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Efficacy of anti-influenza peptide vaccine in aged mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21048152
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The Toll-Like Receptor 5 Stimulus Bacterial Flagellin Induces Maturation and Chemokine Production in Human Dendritic Cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21048152
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21048152
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21048152
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.4049/JIMMUNOL.1002156
1 reference
stated in
Europe PubMed Central
PMCID
3756556
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048152%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
PMCID
3756556
1 reference
stated in
Europe PubMed Central
PMCID
3756556
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048152%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
PubMed ID
21048152
1 reference
stated in
Europe PubMed Central
PMCID
3756556
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21048152%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
ResearchGate publication ID
47675947
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