(Q37137914)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27454287%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1 (English)

1 reference

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19 March 2020

5

1 reference

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19 March 2020

Christiaan Klijn

14

1 reference

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19 March 2020

Fabricio Loayza-Puch

16

1 reference

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19 March 2020

Sven Rottenberg

19

1 reference

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19 March 2020

Jeroen Demmers

22

1 reference

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19 March 2020

Reuven Agami

24

1 reference

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19 March 2020

Judith Balmaña

25

1 reference

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19 March 2020

Violeta Serra

26

1 reference

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19 March 2020

author name string

Rinske Drost

1

1 reference

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19 March 2020

Kiranjit K Dhillon

2

1 reference

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19 March 2020

Hanneke van der Gulden

3

1 reference

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19 March 2020

Ingrid van der Heijden

4

1 reference

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19 March 2020

Cristina Cruz

6

1 reference

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19 March 2020

Dafni Chondronasiou

7

1 reference

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19 March 2020

Marta Castroviejo-Bermejo

8

1 reference

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19 March 2020

Ute Boon

9

1 reference

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19 March 2020

Eva Schut

10

1 reference

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19 March 2020

Eline van der Burg

11

1 reference

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19 March 2020

Ellen Wientjens

12

1 reference

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19 March 2020

Mark Pieterse

13

1 reference

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19 March 2020

Sjoerd Klarenbeek

15

1 reference

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19 March 2020

Ran Elkon

17

1 reference

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19 March 2020

Liesbeth van Deemter

18

1 reference

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19 March 2020

Marieke van de Ven

20

1 reference

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19 March 2020

Dick H W Dekkers

21

1 reference

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19 March 2020

Dik C van Gent

23

1 reference

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19 March 2020

Toshiyasu Taniguchi

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27454287%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Peter Bouwman

28

1 reference

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19 March 2020

Jos Jonkers

29

1 reference

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19 March 2020

language of work or name

English

0 references

publication date

25 July 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27454287%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

19 March 2020

published in

1 reference

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19 March 2020

volume

126

1 reference

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19 March 2020

issue

8

1 reference

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19 March 2020

page(s)

2903-2918

1 reference

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describes a project that uses

19 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4966325/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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1 reference

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Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins

14 September 2017

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Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial.

14 September 2017

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14 September 2017

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Multiplex genome engineering using CRISPR/Cas systems

14 September 2017

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BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

14 September 2017

1 reference

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BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation

14 September 2017

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Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors

14 September 2017

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Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes

14 September 2017

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BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

14 September 2017

1 reference

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Breast cancer statistics, 2011.

14 September 2017

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Transient suppression of MLH1 allows effective single-nucleotide substitution by single-stranded DNA oligonucleotides.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients

14 September 2017

1 reference

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KC-SMARTR: An R package for detection of statistically significant aberrations in multi-experiment aCGH data.

14 September 2017

1 reference

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Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

BRCA1 and its toolbox for the maintenance of genome integrity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance

14 September 2017

1 reference

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Resistance to therapy caused by intragenic deletion in BRCA2

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Cancer risks among BRCA1 and BRCA2 mutation carriers

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

BRCA1 and BRCA2: chemosensitivity, treatment outcomes and prognosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

BRCA1 interacts with components of the histone deacetylase complex

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

BRCA1 is a component of the RNA polymerase II holoenzyme

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Association of BRCA1 with Rad51 in mitotic and meiotic cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Induction of linear tracks of DNA double-strand breaks by alpha-particle irradiation of cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

A high-throughput functional complementation assay for classification of BRCA1 missense variants

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Effective oligonucleotide-mediated gene disruption in ES cells lacking the mismatch repair protein MSH3.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

A low frequency of non-founder BRCA1 mutations in Ashkenazi Jewish breast-ovarian cancer families

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

THE GENETICS OF BREAST CANCER SUSCEPTIBILITY

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966325

The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons

4 December 2018

1 reference

12 December 2020

Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: the national Israeli study of ovarian cancer

1 reference

12 December 2020

Effect of BRCA Mutations on the Length of Survival in Epithelial Ovarian Tumors

1 reference

12 December 2020

"Ring-fencing" BRCA1 tumor suppressor activity

1 reference

12 December 2020

Clinicopathologic features of BRCA-linked and sporadic ovarian cancer

1 reference

12 December 2020

Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations

1 reference

12 December 2020

The 185delAG mutation (c.68_69delAG) in the BRCA1 gene triggers translation reinitiation at a downstream AUG codon

1 reference

12 December 2020

The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin

1 reference

12 December 2020

Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI70196

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27454287%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27454287%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

PubMed publication ID

27454287

1 reference