(Q37145857)

18 August 2017

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title

Mechanisms of Disease: cancer stem cells--targeting the evil twin (English)

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18 August 2017

neoplastic stem cells

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Andreas Trumpp

1

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author name string

Otmar D Wiestler

series ordinal

2

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18 August 2017

22 April 2008

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Nature Clinical Practice Oncology

18 August 2017

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18 August 2017

5

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18 August 2017

337-347

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18 August 2017

6

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Systemic cancer progression and tumor dormancy: mathematical models meet single cell genomics

18 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

More than just proliferation: Myc function in stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Epithelial stem cells: turning over new leaves

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

A Quantitative Assay for the Number of Murine Lymphoma Cells capable of Proliferation in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Stem cells, cancer, and cancer stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Cancer stem cells: lessons from leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Prospective identification of tumorigenic breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Identification of human brain tumour initiating cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Dormant and self-renewing hematopoietic stem cells and their niches

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Stem cells and their niches

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Bone-marrow haematopoietic-stem-cell niches

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Humoral immunity, inflammation and cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Beyond tumorigenesis: cancer stem cells in metastasis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Niche-to-niche migration of bone-marrow-derived cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Wnt/beta-catenin signaling in development and disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Tissue repair and stem cell renewal in carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Stem cell factor: biology and relevance to clinical practice

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Notch and cancer: a double-edged sword

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Polycomb silencers control cell fate, development and cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

The epigenomics of cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Identification of bronchioalveolar stem cells in normal lung and lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

The clinical significance of circulating tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Models, mechanisms and clinical evidence for cancer dormancy

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

AC133/CD133/Prominin-1

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Cancer stem cells in nervous system tumors

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Cancer: stem cells and brain tumours.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Identification and expansion of human colon-cancer-initiating cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Prospective identification of tumorigenic prostate cancer stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Identification of pancreatic cancer stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Generation of a functional mammary gland from a single stem cell

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Purification and unique properties of mammary epithelial stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

A tumorigenic subpopulation with stem cell properties in melanomas

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44+alpha2beta1+ cell population is enriched in tumor-initiating cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Stem-like cells in bone sarcomas: implications for tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Divergent clinical outcome in two CML patients who discontinued imatinib therapy after achieving a molecular remission

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Discontinuation of imatinib therapy after achieving a molecular response

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Cancer Stem Cells and Radiotherapy: New Insights Into Tumor Radioresistance

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Defining the epithelial stem cell niche in skin

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML).

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Dormancy of mammary carcinoma after mastectomy.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Exploiting tumour hypoxia in cancer treatment

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02).

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

HIF-1 as a target for drug development

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

A perivascular niche for brain tumor stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Disrupting tumour blood vessels

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Blasting away leukemia

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Targeting of CD44 eradicates human acute myeloid leukemic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Tumour stem cells and drug resistance

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

A distinct "side population" of cells with high drug efflux capacity in human tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Delivery of MDR1 small interfering RNA by self-complementary recombinant adeno-associated virus vector

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Tumor growth need not be driven by rare cancer stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117)

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Characterization of acute lymphoblastic leukemia progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Significance of CD90+ cancer stem cells in human liver cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC1110

7 January 2021

Identifiers

DOI

10.1038/NCPONC1110

1 reference

18 August 2017

1 reference

PubMed ID

18431377