(Q37147752)

18 August 2017

1 reference

title

Selective anticancer strategies via intervention of the death pathways relevant to cell transformation (English)

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18 August 2017

6

F Wong-Staal

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18 August 2017

Q-X Li

1

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18 August 2017

D H Yu

2

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18 August 2017

G Liu

3

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18 August 2017

N Ke

4

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18 August 2017

J McKelvy

5

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18 August 2017

publication date

25 April 2008

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Cell Death & Differentiation

18 August 2017

published in

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18 August 2017

volume

15

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18 August 2017

issue

8

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18 August 2017

page(s)

1197-1210

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https://scigraph.springernature.com/pub.10.1038/cdd.2008.48

18 August 2017

exact match

0 references

cites work

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Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

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Mitochondria as therapeutic targets for cancer chemotherapy

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Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme

21 January 2018

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Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells

21 January 2018

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High-throughput measurement of mitochondrial membrane potential in a neural cell line using a fluorescence plate reader

21 January 2018

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A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

21 January 2018

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A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo

21 January 2018

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The inhibitors of apoptosis (IAPs) as cancer targets

21 January 2018

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Oncology. Recruiting the cell's own guardian for cancer therapy.

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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Decitabine activates specific caspases downstream of p73 in myeloid leukemia

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Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation

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A chemical genetics approach for the discovery of apoptosis inducers: from phenotypic cell based HTS assay and structure-activity relationship studies, to identification of potential anticancer agents and molecular targets

21 January 2018

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Metastasis: a question of life or death

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Adhesion dependent signalling in the tumour microenvironment: the future of drug targetting.

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Integrin-linked kinase: a cancer therapeutic target unique among its ILK.

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ILK, PINCH and parvin: the tIPP of integrin signalling

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Cell adhesion: old and new questions

21 January 2018

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Orphan G protein-coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathway

21 January 2018

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Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation

21 January 2018

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Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis

21 January 2018

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PHTS, a novel putative tumor suppressor, is involved in the transformation reversion of HeLaHF cells independently of the p53 pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.48

p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB

21 January 2018

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Molecular mechanisms of "detachment-induced apoptosis--Anoikis".

21 January 2018

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A 96-well surrogate survival assay coupled with a special short interfering RNA vector for assessing cancer gene targets with enhanced signal/noise ratio and its utility in HTS for cancer therapeutic targets

21 January 2018

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Nur77 as a survival factor in tumor necrosis factor signaling

21 January 2018

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Nur77 family of nuclear hormone receptors

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.48

Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.48

G protein-coupled receptor-dependent development of human frontal cortex

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.48

Disease-associated mutations affect GPR56 protein trafficking and cell surface expression.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.48

Biochemical characterization of genetic mutations of GPR56 in patients with bilateral frontoparietal polymicrogyria (BFPP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.48

GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.48

GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.48

A novel functional genomics approach identifies mTERT as a suppressor of fibroblast transformation

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.48

Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.48

A novel RNAi library based on partially randomized consensus sequences of nuclear receptors: identifying the receptors involved in amyloid beta degradation

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Second-generation shRNA libraries covering the mouse and human genomes

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.48

Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.48

Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.48

2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

21 January 2018

1 reference

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Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas.

21 January 2018

1 reference

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Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.48

Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation.

21 January 2018

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Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.48

Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis

21 January 2018

1 reference

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Targeted induction of apoptosis for cancer therapy: current progress and prospects.

21 January 2018

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AMPK, the metabolic syndrome and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.48

5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.48

Glucose metabolism and cancer

21 January 2018

1 reference

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Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.48

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.48

Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.48

De-regulation of GRP stress protein expression in human breast cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.48

Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis

21 January 2018

1 reference

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Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment

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Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME.

21 January 2018

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Hypoxia and drug resistance

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Fingerprinting the circulating repertoire of antibodies from cancer patients

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Expression of stress response protein glucose regulated protein-78 mediated by c-Myb

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Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK

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1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.48

Expression of the pro-angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 by human breast carcinomas is responsive to nutrient deprivation and endoplasmic reticulum stress

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The unfolded protein response: a novel component of the hypoxic stress response in tumors.

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1 reference

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Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

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1 reference

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GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer

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1 reference

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(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78.

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1 reference

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Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78.

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Physiological significance of apoptosis in animal virus infection

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Recent progress in the battle between oncolytic viruses and tumours

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Oncolytic herpes simplex virus vectors for cancer virotherapy

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Herpes simplex virus infection and apoptosis

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An HSV-2-based oncolytic virus deleted in the PK domain of the ICP10 gene is a potent inducer of apoptotic death in tumor cells

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A mutant type 2 herpes simplex virus deleted for the protein kinase domain of the ICP10 gene is a potent oncolytic virus

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Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

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Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

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Infection with oncolytic herpes simplex virus-1 induces apoptosis in neighboring human cancer cells: a potential target to increase anticancer activity

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Newcastle disease virus exerts oncolysis by both intrinsic and extrinsic caspase-dependent pathways of cell death

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Reovirus-induced apoptosis requires both death receptor- and mitochondrial-mediated caspase-dependent pathways of cell death

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The potential of death receptor 4- and 5-directed therapies in the treatment of lung cancer

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One-week 96-well soft agar growth assay for cancer target validation.

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Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia

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BiP, a major chaperone protein of the endoplasmic reticulum lumen, plays a direct and important role in the storage of the rapidly exchanging pool of Ca2+

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7 January 2021

Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions

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Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands

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Effect on tumor cells of blocking survival response to glucose deprivation

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Identifiers

DOI

10.1038/CDD.2008.48

1 reference

18 August 2017

1 reference