(Q37157901)

18 August 2017

1 reference

title

Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms (English)

1 reference

18 August 2017

Arzu Gunes

1

1 reference

PubMed ID

18466106

18 August 2017

Marja-Liisa Dahl

series ordinal

2

1 reference

18 August 2017

1 May 2008

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18 August 2017

1 reference

18 August 2017

9

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18 August 2017

5

1 reference

18 August 2017

625-637

1 reference

Pharmacogenomics and individualized drug therapy

18 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Olanzapine. Pharmacokinetic and pharmacodynamic profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Cytochrome P450 isoforms involved in melatonin metabolism in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P-450-mediated uroporphyrinogen oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Cytochrome P450 activation of arylamines and heterocyclic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

The use of caffeine for enzyme assays: a critical appraisal

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Expression of CYP1A1 and CYP1A2 genes in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Determination of urinary metabolites of caffeine for the assessment of cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activity in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

A distribution study of CYP1A2 phenotypes among smokers and non-smokers in a cohort of healthy Caucasian volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Dietary effect on mixed function P450 1A2 activity assayed by estimation of caffeine metabolism in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Assessment of CYP1A2 activity in clinical practice: why, how, and when?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

CYP1A2 activity, gender and smoking, as variables influencing the toxicity of caffeine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Cytochrome P450 and therapeutic drug monitoring with respect to clozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Influence of patient-related variables on clozapine plasma levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Effects of Gender and Age on Plasma Levels of Clozapine and Its Metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Gender, age, smoking behaviour and plasma clozapine concentrations in 193 Chinese inpatients with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

How important are gender differences in pharmacokinetics?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

The influence of ethnic factors and gender on CYP1A2-mediated drug disposition: a comparative study in Caucasian and Chinese subjects using phenacetin as a marker substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

The contribution of genetically determined oxidation status to inter-individual variation in phenacetin disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Theophylline metabolism: Variation and genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Polymorphism of theophylline metabolism in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Detection of three genetic polymorphisms in the 5'-flanking region and intron 1 of human CYP1A2 in the Japanese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

The effect of the CYP1A2 *1F mutation on CYP1A2 inducibility in pregnant women

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Functional characterization of four allelic variants of human cytochrome P450 1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Identification of a novel splice-site mutation in the CYP1A2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Frequency of -163 C>A and 63 C>G single nucleotide polymorphism of cytochrome P450 1A2 in two African populations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C-->A polymorphism in intron 1 of the CYP1A2 gene: effect of grapefruit juice and low-dose fluvoxamine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Nonresponse to clozapine and ultrarapid CYP1A2 activity: clinical data and analysis of CYP1A2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Could discontinuing smoking be hazardous for patients administered clozapine medication? A case report

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Individual changes in clozapine levels after smoking cessation: results and a predictive model

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Therapeutic drug monitoring data on olanzapine and its N-demethyl metabolite in the naturalistic clinical setting

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Increased bioavailability of oral melatonin after fluvoxamine coadministration.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Influence of cigarette smoking on melatonin levels in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Does hepatic metabolism of melatonin affect the endogenous serum melatonin level in man?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Influence of the genetic polymorphism in the 5'-noncoding region of the CYP1A2 gene on CYP1A2 phenotype and urinary mutagenicity in smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Interaction between CYP1A2-T2467DELT polymorphism and smoking in adenocarcinoma and squamous cell carcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Association of genetic polymorphisms with serum estrogens measured multiple times during a 2-year period in premenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Caffeine intake, CYP1A2 polymorphism and the risk of recurrent pregnancy loss.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Genotyping of four genetic polymorphisms in the CYP1A2 gene in the Egyptian population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

Effect of Caffeine Intake 12 or 24 Hours Prior to Melatonin Intake and CYP1A2*1F Polymorphism on CYP1A2 Phenotyping by Melatonin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.625

21 January 2018

Identifiers

DOI

10.2217/14622416.9.5.625

1 reference

18 August 2017

1 reference

PubMed ID

18466106