(Q34660699)

3 August 2017

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title

How important are gender differences in pharmacokinetics? (English)

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3 August 2017

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3

Hartmut Derendorf

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3 August 2017

Bernd Meibohm

1

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3 August 2017

Ingrid Beierle

series ordinal

2

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3 August 2017

publication date

1 January 2002

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Clinical Pharmacokinetics

3 August 2017

published in

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3 August 2017

volume

41

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3 August 2017

issue

5

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3 August 2017

page(s)

329-342

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Randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in Europe, Australia, and New Zealand

3 August 2017

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12 December 2020

Faster clearance of sustained release verapamil in men versus women: continuing observations on sex-specific differences after oral administration of verapamil

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12 December 2020

Biotransformation of tirilazad in human: 3. tirilazad A-ring reduction by human liver microsomal 5alpha-reductase type 1 and type 2

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12 December 2020

Ethnicity and antipsychotic response

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12 December 2020

Influence of sex and oral contraceptive steroids on paracetamol metabolism

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12 December 2020

Guideline for the study and evaluation of gender differences in the clinical evaluation of drugs; notice.

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12 December 2020

CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: indications for oral contraceptive-related gender differences

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12 December 2020

Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.

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12 December 2020

Gender differences in response to drugs: pain medications.

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12 December 2020

Evidence for the effect of gender on activity of (S)-mephenytoin 4'-hydroxylase (CYP2C19) in a Chinese population.

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12 December 2020

Differences in rhodamine-123 efflux in B-type chronic lymphocytic leukemia suggest possible gender and stage variations in drug-resistance gene activity.

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12 December 2020

Multiple-dose tolerability and pharmacokinetics of tirilazad mesylate at doses of up to 10 mg/kg/day administered over 5-10 days in healthy volunteers

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12 December 2020

Characterization of the mechanisms involved in the gender differences in hepatic taurocholate uptake.

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12 December 2020

Use of probe drugs as predictors of drug metabolism in humans

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12 December 2020

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12 December 2020

Hormonal effects on tirilazad clearance in women: assessment of the role of CYP3A.

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12 December 2020

The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes

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12 December 2020

Gender differences in pharmacokinetics

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12 December 2020

Relative importance of dose, body surface area, sex, and age for 5-fluorouracil clearance

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12 December 2020

Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping

1 reference

12 December 2020

Age and gender related changes in stereoselective pharmacokinetics and pharmacodynamics of verapamil and norverapamil

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12 December 2020

Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy*

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12 December 2020

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12 December 2020

Mdr1 limits CYP3A metabolism in vivo.

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12 December 2020

The erythromycin breath test for the prediction of drug clearance

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12 December 2020

Sex differences in morphine analgesia: an experimental study in healthy volunteers

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12 December 2020

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1 reference

12 December 2020

Verapamil stereoisomers during racemic verapamil administration: effects of aging and comparisons to administration of individual stereoisomers.

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12 December 2020

Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates

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12 December 2020

The influence of gender and sex steroid hormones on the plasma binding of propranolol enantiomers

1 reference

12 December 2020

Nonlinear pharmacokinetics of fluvoxamine and gender differences.

1 reference

12 December 2020

Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication

1 reference

12 December 2020

The effect of phenytoin on the pharmacokinetics of tirilazad mesylate in healthy male volunteers

1 reference

12 December 2020

Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities

1 reference

12 December 2020

The effects of age and gender on the single dose pharmacokinetics of avitriptan administered to healthy volunteers.

1 reference

12 December 2020

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

1 reference

12 December 2020

Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans

1 reference

12 December 2020

Frequency distribution of dapsone N-hydroxylase, a putative probe for P4503A4 activity, in a white population

1 reference

12 December 2020

Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism

1 reference

12 December 2020

Erythrocyte catechol-O-methyltransferase activity in a Swedish population

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12 December 2020

Plasma protein binding displacement interactions--why are they still regarded as clinically important?

1 reference

12 December 2020

Investigational new drug applications; amendment to clinical hold regulations for products intended for life-threatening diseases and conditions. Food and Drug Administration, HHS. Final rule

1 reference

12 December 2020

Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine

1 reference

12 December 2020

Human liver dehydroepiandrosterone sulfotransferase: nature and extent of individual variation

1 reference

12 December 2020

Influence of sex and age on fluorouracil clearance

1 reference

12 December 2020

Individualized dosing of amonafide based on a pharmacodynamic model incorporating acetylator phenotype and gender.

1 reference

12 December 2020

Gender differences in psychotropic drug metabolism

1 reference

12 December 2020

Analysis of pharmacokinetic profiles in 232 renal and 87 cardiac allograft recipients treated with cyclosporine

1 reference

12 December 2020

The expression of multidrug resistance protein in human gastrointestinal tract carcinomas.

1 reference

12 December 2020

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

1 reference

12 December 2020

Effect of age, gender, and obesity on midazolam kinetics.

1 reference

12 December 2020

Human cytochrome P4501A2

1 reference

12 December 2020

Population pharmacokinetics of tirilazad: effects of weight, gender, concomitant phenytoin, and subarachnoid hemorrhage

1 reference

12 December 2020

Population pharmacokinetic analysis of mizolastine and validation from sparse data on patients using the nonparametric maximum likelihood method

1 reference

12 December 2020

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

1 reference

12 December 2020

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

12 December 2020

Glucuronidation in humans. Pharmacogenetic and developmental aspects

1 reference

12 December 2020

Evaluation of the pharmacokinetics and tolerability of tirilazad mesylate, a 21-aminosteroid free radical scavenger: I. Single-dose administration

1 reference

12 December 2020

Cytochrome P450 2E1: its clinical and toxicological role

1 reference

12 December 2020

Effect of age and gender on the activity of human hepatic CYP3A

1 reference

12 December 2020

Effect of age and gender on the pharmacokinetics of grepafloxacin.

1 reference

12 December 2020

Pharmacokinetics of sertraline and its N-demethyl metabolite in elderly and young male and female volunteers.

1 reference

12 December 2020

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

1 reference

12 December 2020

Steady-state pharmacokinetic properties of pramipexole in healthy volunteers.

1 reference

12 December 2020

Drug interactions with oral contraceptives

1 reference

12 December 2020

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

12 December 2020

Effects of age and gender on in vitro properties of human liver microsomal monooxygenases

1 reference

12 December 2020

In vivo higher glucuronidation of mycophenolic acid in male than in female recipients of a cadaveric kidney allograft and under immunosuppressive therapy with mycophenolate mofetil

1 reference

12 December 2020

Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients

1 reference

12 December 2020

Pharmacokinetic changes during pregnancy and their clinical relevance

1 reference

12 December 2020

Pharmacogenomics: translating functional genomics into rational therapeutics

1 reference

12 December 2020

Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects

1 reference

12 December 2020

Biotransformation of tirilazad in human: 4. effect of finasteride on tirilazad clearance and reduced metabolite formation

1 reference

12 December 2020

Effects of gender and age on plasma levels of clozapine and its metabolites: analyzed by critical statistics

1 reference

12 December 2020

Gender differences in expression of organic cation transporter OCT2 in rat kidney

1 reference

12 December 2020

Age and gender influence the stereoselective pharmacokinetics of propranolol

1 reference

12 December 2020

Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms

1 reference

12 December 2020

Assessment of effect of food, gender, and intra-subject variability in the pharmacokinetics of avitriptan.

1 reference

12 December 2020

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

1 reference

12 December 2020

Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers

1 reference

12 December 2020

1 reference

12 December 2020

Thiopurine methyltransferase activity in American white subjects and black subjects

1 reference

12 December 2020

Sex-difference and the effects of smoking and oral contraceptive steroids on the kinetics of diflunisal

1 reference

12 December 2020

Pharmacokinetic Drug Interactions with Oral Contraceptives

1 reference

12 December 2020

Comparison of urinary 6-beta-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity

1 reference

12 December 2020

Zidovudine glucuronidation in human liver: interindividual variability.

1 reference

12 December 2020

Effects of age, gender and oral contraceptives on intramuscular midazolam pharmacokinetics.

1 reference

12 December 2020

Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen.

1 reference

12 December 2020

Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.

1 reference

12 December 2020

Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population

1 reference

12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

12 December 2020

Oxaprozin and piroxicam, nonsteroidal antiinflammatory drugs with long half-lives: effect of protein-binding differences on steady-state pharmacokinetics.

1 reference

12 December 2020

Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil

1 reference

12 December 2020

Is it sex or is it gender?

1 reference

12 December 2020

Gender does not affect the degree of induction of tirilazad clearance by phenobarbital.

1 reference

12 December 2020

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

1 reference

12 December 2020

Gender as a Risk Factor for Adverse Events to Medications

1 reference

12 December 2020

Population-based investigation of relative clearance of digoxin in Japanese patients by multiple trough screen analysis: an update.

1 reference

12 December 2020

Digoxin population pharmacokinetics from routine clinical data: role of patient characteristics for estimating dosing regimens

1 reference

12 December 2020

Interethnic and interindividual variabilities of platelet sulfotransferases activity in Italians and Finns

1 reference

12 December 2020

Evaluation of the pharmacokinetics and tolerability of tirilazad mesylate, a 21-aminosteroid free radical scavenger: II. Multiple-dose administration

1 reference

12 December 2020

CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

1 reference

12 December 2020

Lack of a pharmacokinetic/pharmacodynamic interaction between nimodipine and tirilazad mesylate in healthy volunteers

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12 December 2020

Effect of age and gender on tirilazad pharmacokinetics in humans

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12 December 2020

Gender differences in pharmacokinetics and pharmacodynamics

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12 December 2020

Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms.

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12 December 2020

Drug therapy: drug disposition in old age.

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12 December 2020

Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan

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12 December 2020

Race and sex influence clearance of nifedipine: results of a population study

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12 December 2020

Effect of gender on the pharmacokinetics of ofloxacin

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12 December 2020

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test

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12 December 2020

Interethnic difference in thiopurine methyltransferase activity

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12 December 2020

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

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12 December 2020

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

1 reference

12 December 2020

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)

1 reference

12 December 2020

Factors influencing elimination and distribution of fleroxacin: metaanalysis of individual data from 10 pharmacokinetic studies

1 reference

12 December 2020

Genetic polymorphism of S-mephenytoin hydroxylation

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12 December 2020

Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs

1 reference

12 December 2020

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12 December 2020

Predicting effective drug concentrations for individual patients. Determinants of pharmacodynamic variability

1 reference

12 December 2020

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

12 December 2020

Influence of gender on the pharmacokinetics and pharmacodynamics of drugs.

1 reference

12 December 2020

Erythrocyte COMT-activity in patients with affective disorders

1 reference

12 December 2020

Molecular genetics of the human cytochrome P450 monooxygenase superfamily

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12 December 2020

Noninvasive tests of CYP3A enzymes

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12 December 2020

Cytochrome P450 3A: ontogeny and drug disposition

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12 December 2020

Gender-specific effects on verapamil pharmacokinetics and pharmacodynamics in humans

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12 December 2020

Gender effects in pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

Human liver catechol-O-methyltransferase pharmacogenetics

1 reference

12 December 2020

Hormonal regulation of organic cation transporter OCT2 expression in rat kidney

1 reference

12 December 2020

P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs

1 reference

12 December 2020

Hepatic cytochrome P-4503A (CYP3A) activity in the elderly

1 reference

12 December 2020

The influence of ethnic factors and gender on CYP1A2-mediated drug disposition: a comparative study in Caucasian and Chinese subjects using phenacetin as a marker substrate

1 reference

12 December 2020

Use of the erythromycin breath test for in vivo assessments of cytochrome P4503A activity and dosage individualization

1 reference

12 December 2020

The new angiotensin II receptor antagonist, irbesartan: pharmacokinetic and pharmacodynamic considerations

1 reference

12 December 2020

Imipramine serum protein binding in healthy subjects

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12 December 2020

Gender differences in human pharmacokinetics and pharmacodynamics

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12 December 2020

Update: clinically significant cytochrome P-450 drug interactions

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12 December 2020

Greater quinidine-induced QTc interval prolongation in women

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12 December 2020

Gender differences in labetalol kinetics: importance of determining stereoisomer kinetics for racemic drugs

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12 December 2020

Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs

1 reference

12 December 2020

Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A.

1 reference

12 December 2020

The influence of age and gender on the stereoselective metabolism and pharmacokinetics of mephobarbital in humans

1 reference

12 December 2020

Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1.

1 reference

12 December 2020

MRP expression in acute myeloid leukemia. An update.

1 reference

12 December 2020

Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription

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12 December 2020

Alpha-1-acid glycoprotein concentration and the protein binding of disopyramide in healthy subjects

1 reference

12 December 2020

Vancomycin pharmacokinetics in a patient population: effect of age, gender, and body weight.

1 reference

12 December 2020

Effect of age and gender on azimilide pharmacokinetics after a single oral dose of azimilide dihydrochloride.

1 reference

12 December 2020

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin.

1 reference

12 December 2020

Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine

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12 December 2020

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12 December 2020

Clinically Relevant Pharmacology of Selective Serotonin Reuptake Inhibitors

1 reference

12 December 2020

10.2165/00003088-200241050-00002

Identifiers

DOI

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Dimensions Publication ID

3 August 2017

1047035636

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