(Q37161909)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23331248%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Pharmacokinetic and pharmacodynamic evaluation of linagliptin in African American patients with type 2 diabetes mellitus (English)

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22 February 2020

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1 reference

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1

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22 February 2020

author name string

Stephan Glund

2

1 reference

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22 February 2020

Dominick Lionetti

3

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22 February 2020

C James Kissling

4

1 reference

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22 February 2020

Julian Righetti

5

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22 February 2020

Sanjay Patel

6

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22 February 2020

Ulrike Graefe-Mody

7

1 reference

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22 February 2020

Silke Retlich

8

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22 February 2020

Hans-Juergen Woerle

9

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22 February 2020

language of work or name

English

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publication date

1 September 2013

1 reference

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British Journal of Clinical Pharmacology

22 February 2020

published in

1 reference

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22 February 2020

volume

76

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22 February 2020

issue

3

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22 February 2020

page(s)

445-454

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Linagliptin, a dipeptidyl peptidase-4 inhibitor in development for the treatment of type 2 diabetes mellitus: a Phase I, randomized, double-blind, placebo-controlled trial of single and multiple escalating doses in healthy adult male Japanese subjec

22 February 2020

cites work

1 reference

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Heart Disease and Stroke Statistics--2010 Update: A Report From the American Heart Association

9 September 2017

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A perspective on African American participation in clinical trials

9 September 2017

1 reference

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Diabetes in African Americans

9 September 2017

1 reference

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Polymorphisms in the ABC drug transporter gene MDR1.

9 September 2017

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Participation of racial/ethnic groups in clinical trials and race-related labeling: a review of new molecular entities approved 1995-1999.

9 September 2017

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Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

9 September 2017

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Pharmacokinetics and pharmacodynamics of single rising intravenous doses (0.5 mg-10 mg) and determination of absolute bioavailability of the dipeptidyl peptidase-4 inhibitor linagliptin (BI 1356) in healthy male subjects

9 September 2017

1 reference

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Combined CYP2C9, VKORC1 and CYP4F2 frequencies among racial and ethnic groups

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769671

Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769671

Increased insulin resistance and insulin secretion in nondiabetic African-Americans and Hispanics compared with non-Hispanic whites. The Insulin Resistance Atherosclerosis Study

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769671

Pharmacokinetics of single and multiple oral doses of 5 mg linagliptin in healthy Chinese volunteers

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769671

Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor linagliptin: a 4-week multicenter, randomized, double-blind, placebo-controlled phase IIa study in Japanese type 2 diabetes patients.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769671

The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769671

Binding to dipeptidyl peptidase-4 determines the disposition of linagliptin (BI 1356)--investigations in DPP-4 deficient and wildtype rats

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769671

Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769671

Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769671

Ethnic-specific pathways to obesity-related disease: the Hispanic vs. African-American paradox

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769671

Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3769671

Safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of BI 1356, an inhibitor of dipeptidyl peptidase 4, in healthy male volunteers

3 September 2018

1 reference

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(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared wi

3 September 2018

1 reference

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Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations

3 September 2018

1 reference

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CYP3A4*1B and NAT2*14 alleles in a native African population.

3 September 2018

1 reference

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Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.

3 September 2018

1 reference

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Frequency of C3435T polymorphism of MDR1 gene in African people

3 September 2018

1 reference

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Pharmacokinetic and prognostic significance of intestinal MDR1 expression in recipients of living-donor liver transplantation

3 September 2018

1 reference

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MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

3 September 2018

1 reference

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Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: ethnic distribution and implications for prostate cancer risk. Mutations in brief no. 191. Online

3 September 2018

1 reference

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Representation of American blacks in clinical trials of new drugs

3 September 2018

1 reference

12 December 2020

Examples abound of gaps in medical knowledge because of groups excluded from scientific study

1 reference

12 December 2020

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

1 reference

12 December 2020

Black-White health disparities in the United States and Chicago: a 15-year progress analysis

1 reference

12 December 2020

Identifiers

DOI

10.1111/BCP.12077

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23331248%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23331248%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

23331248

1 reference