(Q37163028)

18 August 2017

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title

Spatial and temporal coordination of mitosis by Ran GTPase (English)

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18 August 2017

Paul R Clarke

1

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18 August 2017

Chuanmao Zhang

series ordinal

2

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18 August 2017

language of work or name

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14 May 2008

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Nature Reviews Molecular Cell Biology

18 August 2017

published in

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18 August 2017

volume

9

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18 August 2017

issue

6

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18 August 2017

page(s)

464-477

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https://scigraph.springernature.com/pub.10.1038/nrm2410

18 August 2017

exact match

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cites work

Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line

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A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: purification, biochemical characterization, and identification of a leucine-rich repeat motif

21 January 2018

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Premature chromosome condensation is induced by a point mutation in the hamster RCC1 gene

21 January 2018

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Effects of mutant Ran/TC4 proteins on cell cycle progression.

21 January 2018

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Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

21 January 2018

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Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide

31 March 2020

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The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

31 March 2020

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Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor

31 March 2020

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Transport between the cell nucleus and the cytoplasm

31 March 2020

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Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.

31 March 2020

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Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

31 March 2020

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Structural view of the Ran-Importin beta interaction at 2.3 A resolution

31 March 2020

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Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1

31 March 2020

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NTF2 mediates nuclear import of Ran.

31 March 2020

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Nuclear import of Ran is mediated by the transport factor NTF2.

31 March 2020

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Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation

31 March 2020

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The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA

31 March 2020

1 reference

Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)

31 March 2020

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The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1

31 March 2020

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Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells

31 March 2020

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N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis

31 March 2020

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Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B

31 March 2020

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RanGAP1 induces GTPase activity of nuclear Ras-related Ran

31 March 2020

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RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae

31 March 2020

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RanGAP mediates GTP hydrolysis without an arginine finger

31 March 2020

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Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1

31 March 2020

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Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4

31 March 2020

1 reference

A giant nucleopore protein that binds Ran/TC4

31 March 2020

1 reference

Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region

31 March 2020

1 reference

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

31 March 2020

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A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

31 March 2020

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RanBP2 associates with Ubc9p and a modified form of RanGAP1

31 March 2020

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Analysis of a RanGTP-regulated gradient in mitotic somatic cells

31 March 2020

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The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

31 March 2020

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The direction of transport through the nuclear pore can be inverted

31 March 2020

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CRM1 is an export receptor for leucine-rich nuclear export signals

31 March 2020

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CRM1 is responsible for intracellular transport mediated by the nuclear export signal

31 March 2020

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Evidence for a role of CRM1 in signal-mediated nuclear protein export

31 March 2020

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Exportin 1 (Crm1p) is an essential nuclear export factor

31 March 2020

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Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex

31 March 2020

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RanBP1 is crucial for the release of RanGTP from importin β-related nuclear transport factors

31 March 2020

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Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

31 March 2020

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Karyopherin flexibility in nucleocytoplasmic transport

31 March 2020

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Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

31 March 2020

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The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion

31 March 2020

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FG-Rich Repeats of Nuclear Pore Proteins Form a Three-Dimensional Meshwork with Hydrogel-Like Properties

31 March 2020

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The molecular architecture of the nuclear pore complex

31 March 2020

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Nanomechanical basis of selective gating by the nuclear pore complex

31 March 2020

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Nuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanisms

31 March 2020

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The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/Qip

31 March 2020

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The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus

31 March 2020

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A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.

31 March 2020

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Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1

31 March 2020

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Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor

31 March 2020

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Premature of chromosome condensation in a ts DNA- mutant of BHK cells.

31 March 2020

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Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression

31 March 2020

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Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

31 March 2020

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The ran GTPase regulates mitotic spindle assembly.

31 March 2020

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Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran

31 March 2020

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Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran

31 March 2020

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Dynamic instability of microtubule growth

31 March 2020

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Beyond self-assembly: from microtubules to morphogenesis

31 March 2020

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Respective roles of centrosomes and chromatin in the conversion of microtubule arrays from interphase to metaphase

31 March 2020

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Long-Range Communication between Chromatin and Microtubules in Xenopus Egg Extracts

31 March 2020

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The mitotic spindle: a self-made machine

31 March 2020

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Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts

31 March 2020

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Centrosome-independent mitotic spindle formation in vertebrates

31 March 2020

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Efficient chromosome capture requires a bias in the 'search-and-capture' process during mitotic-spindle assembly

31 March 2020

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Cooperative mechanisms of mitotic spindle formation

31 March 2020

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Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.

31 March 2020

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Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly.

31 March 2020

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Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities

31 March 2020

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Bipolarization and poleward flux correlate during Xenopus extract spindle assembly

31 March 2020

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A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo

31 March 2020

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Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells

31 March 2020

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Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis

31 March 2020

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Crm1 is a mitotic effector of Ran-GTP in somatic cells

31 March 2020

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Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts

31 March 2020

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Spatial coordination of spindle assembly by chromosome-mediated signaling gradients

31 March 2020

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Cell biology. A gradient signal orchestrates the mitotic spindle

31 March 2020

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The human CAS protein which is homologous to the CSE1 yeast chromosome segregation gene product is associated with microtubules and mitotic spindle

31 March 2020

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Importin beta is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells

31 March 2020

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Mammalian RanBP1 regulates centrosome cohesion during mitosis

31 March 2020

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Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity.

31 March 2020

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Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly.

31 March 2020

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SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles

31 March 2020

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Molecular mechanisms of kinetochore capture by spindle microtubules.

31 March 2020

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The Ran GTPase mediates chromatin signaling to control cortical polarity during polar body extrusion in mouse oocytes.

31 March 2020

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Importin beta is a mitotic target of the small GTPase Ran in spindle assembly

31 March 2020

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Role of importin-beta in coupling Ran to downstream targets in microtubule assembly

31 March 2020

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TPX2, A novel xenopus MAP involved in spindle pole organization

31 March 2020

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Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

31 March 2020

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Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation

31 March 2020

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A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

31 March 2020

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HURP is part of a Ran-dependent complex involved in spindle formation

31 March 2020

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HURP Is a Ran-Importin β-Regulated Protein that Stabilizes Kinetochore Microtubules in the Vicinity of Chromosomes

31 March 2020

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HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.

31 March 2020

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XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly

31 March 2020

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The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly

31 March 2020

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Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate

31 March 2020

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A mitotic lamin B matrix induced by RanGTP required for spindle assembly

31 March 2020

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Regulation of nuclear lamin polymerization by importin alpha.

31 March 2020

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Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid.

31 March 2020

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Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p

31 March 2020

1 reference

Nuclear import of the TATA-binding protein: mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting

31 March 2020

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Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis

31 March 2020

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The Crm de la crème of mitosis.

31 March 2020

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Emerging roles of the SUMO pathway in mitosis

31 March 2020

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The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function

31 March 2020

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Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication

31 March 2020

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Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein

31 March 2020

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NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules

31 March 2020

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A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast

31 March 2020

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A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.

31 March 2020

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GTP hydrolysis by Ran is required for nuclear envelope assembly.

31 March 2020

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Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts

31 March 2020

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Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly

31 March 2020

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RanGTP mediates nuclear pore complex assembly

31 March 2020

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Nuclear pores form de novo from both sides of the nuclear envelope

31 March 2020

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Ran alters nuclear pore complex conformation.

31 March 2020

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Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos

31 March 2020

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The Ran GTPase cycle is required for yeast nuclear pore complex assembly

31 March 2020

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Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system

31 March 2020

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Role of importin-beta in the control of nuclear envelope assembly by Ran.

31 March 2020

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The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo.

31 March 2020

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Importin β Negatively Regulates Nuclear Membrane Fusion and Nuclear Pore Complex Assembly

31 March 2020

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Importin alpha associates with membranes and participates in nuclear envelope assembly in vitro

31 March 2020

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Nuclear pores: sowing the seeds of assembly on the chromatin landscape.

31 March 2020

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MEL-28 is downstream of the Ran cycle and is required for nuclear-envelope function and chromatin maintenance.

31 March 2020

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MEL-28, a novel nuclear-envelope and kinetochore protein essential for zygotic nuclear-envelope assembly in C. elegans

31 March 2020

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ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division

31 March 2020

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MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly

31 March 2020

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ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensing

31 March 2020

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RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation

31 March 2020

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RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly

31 March 2020

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Mutations in fission yeast Cut15, an importin alpha homolog, lead to mitotic progression without chromosome condensation

31 March 2020

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Partial nuclear pore complex disassembly during closed mitosis in Aspergillus nidulans

31 March 2020

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Cell cycle regulated transport controlled by alterations in the nuclear pore complex.

31 March 2020

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The Ran GTPase regulates kinetochore function

31 March 2020

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A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly

31 March 2020

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The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.

31 March 2020

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The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis

31 March 2020

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The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly

31 March 2020

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The conserved Nup107-160 complex is critical for nuclear pore complex assembly

31 March 2020

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Nup358 integrates nuclear envelope breakdown with kinetochore assembly

31 March 2020

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From pore to kinetochore and back: regulating envelope assembly

31 March 2020

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The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly

31 March 2020

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BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition

31 March 2020

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Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A

31 March 2020

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Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal

31 March 2020

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A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions

31 March 2020

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Xnf7 contributes to spindle integrity through its microtubule-bundling activity

31 March 2020

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Phosphorylation of maskin by Aurora-A is regulated by RanGTP and importin beta

31 March 2020

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Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast.

31 March 2020

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Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin beta

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2410

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Dimensions Publication ID

18 August 2017

1015207461

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