(Q37164036)

18 August 2017

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title

Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal (English)

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18 August 2017

stem cell self-renewal

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1

Leonard I Zon

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PubMed ID

18480811

18 August 2017

language of work or name

English

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publication date

1 May 2008

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18 August 2017

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18 August 2017

453

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18 August 2017

306-313

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18 August 2017

7193

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https://scigraph.springernature.com/pub.10.1038/nature07038

18 August 2017

0 references

cites work

Self-renewal of the adult skeletal muscle satellite cell

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HOX gene regulation in acute myeloid leukemia: CDX marks the spot?

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7 January 2021

SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity

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7 January 2021

Neural stem cells in mammalian development

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7 January 2021

Male and female Drosophila germline stem cells: two versions of immortality.

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7 January 2021

Cancer stem cells in solid tumors

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https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Asymmetric cell divisions sustain long-term hematopoiesis from single-sorted human fetal liver cells

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https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs

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https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteins.

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https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Asymmetric inheritance of mother versus daughter centrosome in stem cell division

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Male germline stem cells: from mice to men.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Purification and unique properties of mammary epithelial stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Self-renewal and cancer of the gut: two sides of a coin.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Nanog and transcriptional networks in embryonic stem cell pluripotency

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Functional identification of the actual and potential stem cell compartments in mouse spermatogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Skin stem cells: rising to the surface

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Of lineage and legacy: the development of mammalian hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Mesodermal Wnt2b signalling positively regulates liver specification.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

A role for Wnt signalling in self-renewal of haematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Distinct Wnt signaling pathways have opposing roles in appendage regeneration

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Smad4 is critical for self-renewal of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

fgf20 is essential for initiating zebrafish fin regeneration.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Hematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Variations on a theme: Hox and Wnt combinatorial regulation during animal development.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Cdx4 is a direct target of the canonical Wnt pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic defects

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Dysregulated expression of stem cell factor Bmi1 in precancerous lesions of the gastrointestinal tract

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Definitive hematopoiesis requires the mixed-lineage leukemia gene

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Chemical genetics reveals a complex functional ground state of neural stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Zfx controls the self-renewal of embryonic and hematopoietic stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

"Stemness": transcriptional profiling of embryonic and adult stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

A stem cell molecular signature

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Dual role of Mpl receptor during the establishment of definitive hematopoiesis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Activation of Wnt signaling in hematopoietic regeneration

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE07038

7 January 2021

Identifiers

DOI

10.1038/NATURE07038

1 reference

PubMed ID

18480811

Dimensions Publication ID

18 August 2017

0 references

1 reference

PubMed ID

18480811