(Q50926584)

25 March 2018

title

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. (English)

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25 March 2018

author

Bo Torben Porse

3

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25 March 2018

Sten Eirik W Jacobsen

4

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25 March 2018

Peggy Kirstetter

object named as

Peggy Kirstetter

1

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Claus Nerlov

5

object named as

Claus Nerlov

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25 March 2018

author name string

Kristina Anderson

2

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25 March 2018

language of work or name

English

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publication date

3 September 2006

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25 March 2018

published in

Nature Immunology

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25 March 2018

volume

7

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25 March 2018

page(s)

1048-1056

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25 March 2018

issue

10

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25 March 2018

The Wnt signaling pathway in development and disease

cites work

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Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

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Activation of the Wnt signaling pathway in chronic lymphocytic leukemia

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Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

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Beta-catenin is dispensable for hematopoiesis and lymphopoiesis

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Control of lymphocyte differentiation by the LEF-1/TCF family of transcription factors

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Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1

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Deletion of β-catenin impairs T cell development

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Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development.

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Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

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Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts

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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

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Identification of clonogenic common lymphoid progenitors in mouse bone marrow

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B cell development pathways

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B lymphocyte-specific, Cre-mediated mutagenesis in mice

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A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

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Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.

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Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.

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Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells

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PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

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HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

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Functional consequences of integrin gene mutations in mice

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Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cells

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The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential

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Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation

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Wnt proteins are lipid-modified and can act as stem cell growth factors

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Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1

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Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors

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Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism

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From stem cell to T cell: one route or many?

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Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.

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Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice

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E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

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Inducible gene targeting in mice

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T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors

21 January 2018

1 reference

Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation.

21 January 2018

1 reference

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

21 January 2018

1 reference

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

21 January 2018

1 reference

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

21 January 2018

1 reference

7 January 2021

The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival

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7 January 2021

Thymopoiesis independent of common lymphoid progenitors

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7 January 2021

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

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7 January 2021

Identifiers

DOI

10.1038/NI1381

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25 March 2018

PubMed ID

16951689

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25 March 2018