(Q37165495)

18 August 2017

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title

Safety of the nonselective NSAID nabumetone : focus on gastrointestinal tolerability (English)

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18 August 2017

Bernard Bannwarth

1

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18 August 2017

1 January 2008

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18 August 2017

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18 August 2017

31

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18 August 2017

6

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18 August 2017

485-503

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https://scigraph.springernature.com/pub.10.2165/00002018-200831060-00004

18 August 2017

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Current use of nonsteroidal antiinflammatory drugs and the risk of acute myocardial infarction

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Nonsteroidal anti-inflammatory drug-induced hepatotoxicity

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Efficacy and safety of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in the elderly

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Comparison of the upper gastrointestinal safety of Arthrotec 75 and nabumetone in osteoarthritis patients at high risk for developing nonsteroidal anti-inflammatory drug-induced gastrointestinal ulcers

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Efficacy of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis

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Treatment of patients with osteoarthritis with rofecoxib compared with nabumetone

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Mitochondrial damage: a possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine

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A longterm endoscopic evaluation of patients with arthritis treated with nabumetone vs naproxen

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Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation

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Importance of local versus systemic effects of non-steroidal anti-inflammatory drugs in increasing small intestinal permeability in man

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12 December 2020

An overview of the long-term safety experience of nabumetone

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12 December 2020

A multicenter, randomized, controlled trial to evaluate the safety profile, tolerability, and efficacy of rofecoxib in advanced elderly patients with osteoarthritis

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Nonsteroidal anti-inflammatory drugs and heart failure

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Epidemiology of NSAID induced gastrointestinal complications.

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12 December 2020

Gastrointestinal safety profile of nabumetone: a meta-analysis

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12 December 2020

Effects of nabumetone, celecoxib, and ibuprofen on blood pressure control in hypertensive patients on angiotensin converting enzyme inhibitors

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12 December 2020

Worldwide safety experience with nabumetone

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12 December 2020

Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage

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12 December 2020

Nonsteroidal antiinflammatory drugs and the small intestine

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12 December 2020

Safety evaluation of nabumetone in United States clinical trials

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12 December 2020

Nabumetone induces less gastrointestinal mucosal changes than diclofenac retard

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12 December 2020

Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis

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12 December 2020

Adverse effects of conventional non-steroidal anti-inflammatory drugs on the upper gastrointestinal tract

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12 December 2020

Treatment of elderly patients with nabumetone or diclofenac: gastrointestinal safety profile

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12 December 2020

Early pathogenic events in NSAID-induced gastrointestinal damage

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12 December 2020

Gastric ulcer formation and cyclo-oxygenase inhibition in cat antrum follows parenteral administration of aspirin but not salicylate

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12 December 2020

Use of non-aspirin nonsteroidal antiinflammatory drugs and the risk of cardiovascular events

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12 December 2020

An open label study to establish dosing recommendations for nabumetone in juvenile rheumatoid arthritis

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Lumiracoxib in the management of osteoarthritis and acute pain

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12 December 2020

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Intestinal tract injury by drugs: Importance of metabolite delivery by yellow bile road

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Tolerability and efficacy of nabumetone and naproxen in the treatment of rheumatoid arthritis

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12 December 2020

Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: cohort study

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12 December 2020

Randomized trial of low-dose misoprostol and naproxen vs. nabumetone to prevent recurrent upper gastrointestinal haemorrhage in users of non-steroidal anti-inflammatory drugs

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12 December 2020

Risk of hospitalization with peptic ulcer disease or gastrointestinal hemorrhage associated with nabumetone, Arthrotec, diclofenac, and naproxen in a population based cohort study

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12 December 2020

Nabumetone in elderly patients with osteoarthritis: economic benefits versus ibuprofen alone or ibuprofen plus misoprostol

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12 December 2020

Nabumetone compared with naproxen in the treatment of rheumatoid arthritis: a multicenter, double blind, randomized, parallel group trial in hospital outpatients

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12 December 2020

Systematic review: the hepatotoxicity of non-steroidal anti-inflammatory drugs

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12 December 2020

A decision analysis model in the evaluation of NSAIDs in a managed care setting: a case study

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12 December 2020

Where is the evidence that cyclooxygenase inhibition is the primary cause of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal injury? Topical injury revisited

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12 December 2020

Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases

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12 December 2020

Antiinflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6-methoxy-2-naphthylacetic acid (6MNA). Comparative studies with indomethacin

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12 December 2020

Gastroduodenal tolerability of nabumetone versus naproxen in the treatment of rheumatic patients

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12 December 2020

COX-2 selective inhibitors: analysis of the renal effects

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12 December 2020

Safety and efficacy of nabumetone in osteoarthritis: emphasis on gastrointestinal safety

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12 December 2020

Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial

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12 December 2020

Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells

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12 December 2020

Efficacy and safety of rofecoxib 12.5 mg versus nabumetone 1,000 mg in patients with osteoarthritis of the knee: a randomized controlled trial

1 reference

12 December 2020

NSAID injury to the gastrointestinal tract: evidence that NSAIDs interact with phospholipids to weaken the hydrophobic surface barrier and induce the formation of unstable pores in membranes

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12 December 2020

Nonsteroidal anti-inflammatory drugs and risk of ARF in the general population

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12 December 2020

The unique pharmacologic profile of nabumetone

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12 December 2020

Renal effects of non-steroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors

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12 December 2020

Interaction of indomethacin and naproxen with gastric surface-active phospholipids: a possible mechanism for the gastric toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs)

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12 December 2020

Clinical pharmacokinetics of nabumetone. The dawn of selective cyclo-oxygenase-2 inhibition?

1 reference

12 December 2020

Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs.

1 reference

12 December 2020

The different patterns of blood pressure elevation by rofecoxib and nabumetone.

1 reference

12 December 2020

A population based historical cohort study of the mortality associated with nabumetone, Arthrotec, diclofenac, and naproxen

1 reference

12 December 2020

Do selective cyclo-oxygenase-2 inhibitors have a future?

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drugs and hepatic toxicity: a systematic review of randomized controlled trials in arthritis patients

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12 December 2020

A multicenter study of nabumetone and diclofenac SR in patients with osteoarthritis

1 reference

12 December 2020

Rationalizing cyclooxygenase (COX) inhibition for maximal efficacy and minimal adverse events

1 reference

12 December 2020

Safety experience with nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis.

1 reference

12 December 2020

Time dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach

1 reference

12 December 2020

Intestinal permeability and inflammation in patients on NSAIDs

1 reference

12 December 2020

Profile and mechanisms of gastrointestinal and other side effects of nonsteroidal anti-inflammatory drugs (NSAIDs).

1 reference

12 December 2020

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1 reference

12 December 2020

Gastric mucus and bicarbonate secretion in relation to mucosal protection

1 reference

12 December 2020

A double-masked comparison of Naprelan and nabumetone in osteoarthritis of the knee. Naprelan Study Group

1 reference

12 December 2020

Nabumetone compared with indomethacin in the treatment of osteoarthritis in general practice

1 reference

12 December 2020

The effect of nabumetone and its principal active metabolite on in vitro human gastric mucosal prostanoid synthesis and platelet function

1 reference

12 December 2020

Spontaneous reports of hypertension leading to hospitalisation in association with rofecoxib, celecoxib, nabumetone and oxaprozin

1 reference

12 December 2020

The coxibs, selective inhibitors of cyclooxygenase-2.

1 reference

12 December 2020

A microcomputer-assisted study of nabumetone and slow release diclofenac in osteoarthritis.

1 reference

12 December 2020

Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group

1 reference

12 December 2020

NSAID use and the risk of hospitalization for first myocardial infarction in the general population: a nationwide case-control study from Finland

1 reference

12 December 2020

Lack of enterohepatic circulation of the active metabolite of nabumetone in humans

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12 December 2020

Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production

1 reference

12 December 2020

10.2165/00002018-200831060-00004

Identifiers

DOI

1 reference

PubMed ID

18484783

Dimensions Publication ID

18 August 2017

0 references

1 reference

PubMed ID

18484783