(Q37185121)

18 August 2017

Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases (English)

1 reference

18 August 2017

1 reference

Yuefeng Peng

1

1 reference

18 August 2017

Haiying Sun

2

1 reference

18 August 2017

Zaneta Nikolovska-Coleska

3

1 reference

18 August 2017

Su Qiu

4

1 reference

18 August 2017

Chao-Yie Yang

5

1 reference

18 August 2017

Jianfeng Lu

6

1 reference

18 August 2017

Qian Cai

7

1 reference

18 August 2017

Han Yi

8

1 reference

18 August 2017

Sanmao Kang

9

1 reference

18 August 2017

Dajun Yang

10

1 reference

18 August 2017

Shaomeng Wang

11

1 reference

18 August 2017

language of work or name

English

0 references

publication date

1 December 2008

1 reference

Journal of Medicinal Chemistry

18 August 2017

1 reference

18 August 2017

51

1 reference

18 August 2017

24

1 reference

18 August 2017

8158-8162

1 reference

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Inhibitor of apoptosis proteins as targets for anticancer therapy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Mechanism of XIAP-mediated inhibition of caspase-9

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

IAP proteins: blocking the road to death's door

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

XIAP: apoptotic brake and promising therapeutic target.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Structural basis of IAP recognition by Smac/DIABLO

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

IAP family proteins--suppressors of apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679375

Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19049347

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19049347

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structure-based design of potent, conformationally constrained Smac mimetics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19049347

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM801254R

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

19049347

1 reference