(Q36950485)

17 August 2017

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title

Inhibitor of apoptosis proteins as targets for anticancer therapy (English)

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17 August 2017

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1

Simone Fulda

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publication date

1 September 2007

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Expert Review of Anticancer Therapy

17 August 2017

published in

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17 August 2017

volume

7

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17 August 2017

issue

9

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17 August 2017

page(s)

1255-1264

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Proliferation, cell cycle and apoptosis in cancer

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

The biochemistry of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Apoptosis: a link between cancer genetics and chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Targeting apoptosis pathways in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Apoptotic DNA fragmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Toxic proteins released from mitochondria in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Four deaths and a funeral: from caspases to alternative mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Pathways of apoptotic and non-apoptotic death in tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

IAP proteins: blocking the road to death's door

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Structural basis of caspase-7 inhibition by XIAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Structural basis for the inhibition of caspase-3 by XIAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Mechanism of XIAP-mediated inhibition of caspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

IAPs, RINGs and ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

CARD proteins as therapeutic targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Livin, a novel inhibitor of apoptosis protein family member

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Validating survivin as a cancer therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

A p34(cdc2) survival checkpoint in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Survivin, versatile modulation of cell division and apoptosis in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

A novel role for XIAP in copper homeostasis through regulation of MURR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Mammalian mitochondrial IAP binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Structural basis of IAP recognition by Smac/DIABLO

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Generation and characterization of Smac/DIABLO-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Quantitatively determined survivin expression levels are of prognostic value in human gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

An IAP-IAP complex inhibits apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Analysis of human transcriptomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Prognostic importance of survivin in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Application of XIAP antisense to cancer and other proliferative disorders: development of AEG35156/ GEM640

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Caspase activation, inhibition, and reactivation: a mechanistic view

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Donor-acceptor (electronic) coupling in the precursor complex to organic electron transfer: intermolecular and intramolecular self-exchange between phenothiazine redox centers

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Peptides targeting caspase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Targeted therapy by disabling crossroad signaling networks: the survivin paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

XAF1 expression is significantly reduced in human melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Promoter CpG hypermethylation and downregulation of XAF1 expression in human urogenital malignancies: implication for attenuated p53 response to apoptotic stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

All-trans retinoic acid induces XAF1 expression through an interferon regulatory factor-1 element in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.7.9.1255

10.1586/14737140.7.9.1255

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference