(Q37198685)

English

Toll-like receptors, transduction-effector pathways, and disease diversity: evidence of an immunobiological paradigm explaining all human illness?

scientific article published on July 2008

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scholarly article

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Europe PubMed Central

PubMed publication ID

18 August 2017

1 reference

Europe PubMed Central

Toll-like receptors, transduction-effector pathways, and disease diversity: evidence of an immunobiological paradigm explaining all human illness? (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

toll-like receptor

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author name string

Timothy J Atkinson

1

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Europe PubMed Central

PubMed publication ID

18 August 2017

publication date

1 July 2008

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Europe PubMed Central

PubMed publication ID

18 August 2017

International Reviews of Immunology

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Europe PubMed Central

PubMed publication ID

18 August 2017

27

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Europe PubMed Central

PubMed publication ID

18 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

255-281

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

The Toll-receptor family and control of innate immunity

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Recognition of microbial infection by Toll-like receptors

1 reference

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21 January 2018

Toll-like receptors: key mediators of microbe detection.

1 reference

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21 January 2018

Innate immunity: the virtues of a nonclonal system of recognition

1 reference

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21 January 2018

How we detect microbes and respond to them: the Toll-like receptors and their transducers

1 reference

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21 January 2018

Role of Toll-like receptors in pathogen recognition.

1 reference

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21 January 2018

The potential for Toll-like receptors to collaborate with other innate immune receptors

1 reference

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21 January 2018

Translational mini-review series on Toll-like receptors: recent advances in understanding the role of Toll-like receptors in anti-viral immunity

1 reference

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21 January 2018

Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells

1 reference

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21 January 2018

The leucine-rich repeat: a versatile binding motif

1 reference

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21 January 2018

Towards an understanding of the signal transduction pathways for interleukin 1.

1 reference

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21 January 2018

The instructive role of innate immunity in the acquired immune response

1 reference

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21 January 2018

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1 reference

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21 January 2018

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression

1 reference

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21 January 2018

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

1 reference

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21 January 2018

The interleukin 1 receptor: ligand interactions and signal transduction

1 reference

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21 January 2018

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

1 reference

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21 January 2018

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

IRAK: a kinase associated with the interleukin-1 receptor

1 reference

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21 January 2018

TRAF6 is a signal transducer for interleukin-1

1 reference

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21 January 2018

The Toll-IL-1 receptor adaptor family grows to five members.

1 reference

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21 January 2018

The role of TRAF6 in signal transduction and the immune response

1 reference

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21 January 2018

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

1 reference

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21 January 2018

MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1

1 reference

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21 January 2018

Pro-inflammatory signaling: last pieces in the NF-kappaB puzzle?

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors: networking for success.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Innate immunity: impact on the adaptive immune response

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors: molecular mechanisms of the mammalian immune response

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Dendritic cells and the control of immunity

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Controlling the Toll road to dendritic cell polarization

1 reference

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21 January 2018

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Differential induction of interleukin-10 and interleukin-12 in dendritic cells by microbial toll-like receptor activators and skewing of T-cell cytokine profiles.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor control of the adaptive immune responses

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Regulation of mammalian defensin expression by Toll-like receptor-dependent and independent signalling pathways

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Activation and regulation of Toll-like receptors 2 and 1 in human leprosy

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Modulation of the host's immune response by schistosome larvae.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

The negative regulation of Toll-like receptor and associated pathways

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Activation of toll-like receptors by microbial lipoproteins: role in host defense

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors: key activators of leucocytes and regulator of haematopoiesis.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors' two-edged sword: when immunity meets apoptosis.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors: balancing host resistance with immune tolerance

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors in systemic autoimmune disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Pattern recognition receptors and their involvement in the pathogenesis of arthritis.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors and their role in the development of autoimmune diseases

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Dendritic cells, Fc{gamma} receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors, endogenous ligands, and systemic autoimmune disease.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Modifying toll-like receptor 9 signaling for therapeutic use.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Tumor necrosis factor alpha blockade treatment down-modulates the increased systemic and local expression of Toll-like receptor 2 and Toll-like receptor 4 in spondylarthropathy.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Association of the polymorphism for Toll-like receptor 2 with type 1 diabetes susceptibility.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 3 gene polymorphisms in South African Blacks with type 1 diabetes.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Novel therapeutic strategies based on toll-like receptor signaling

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors and immune response in allergic disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 4 or 2 agonists decrease allergic inflammation.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Immunobiology of toll-like receptors in allergic disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

The use of Toll-like receptor-7 agonist in the treatment of basal cell carcinoma: an overview

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 4 genetic variation and advanced prostate cancer risk

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Immunomodulatory effects of Toll-like receptor-7 activation on chronic lymphocytic leukemia cells

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

The in vivo antitumoral effects of lipopolysaccharide against glioblastoma multiforme are mediated in part by Toll-like receptor 4.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Increased toll-like receptor 9 expression in cervical neoplasia

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 4 and atherogenesis

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Role of Toll-like receptor 4 in the initiation and progression of atherosclerotic disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

CD14 and toll-like receptor 4: a link between infection and acute coronary events?

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Endotoxin, TLR4 signaling and vascular inflammation: potential therapeutic targets in cardiovascular disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Modulation of atherosclerosis in mice by Toll-like receptor 2

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 2 stimulation induces intimal hyperplasia and atherosclerotic lesion development

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Increased expression of Toll like receptor 4 on peripheral-blood mononuclear cells in patients with coronary arteriosclerosis disease.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

The role of toll-like receptors in the pathogenesis and treatment of dermatological disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 9-induced type I IFN protects mice from experimental colitis

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Immunologic regulation of toll-like receptors in gut epithelium.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 4 deficiency and acute pancreatitis act similarly in reducing host defense during murine Escherichia coli peritonitis

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors, new horizons in sepsis.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors as potential therapeutic targets for multiple diseases

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Evidence for association between a Toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors in central nervous system glial inflammation and homeostasis

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseases.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

The innate immunity of the central nervous system in chronic pain: the role of Toll-like receptors

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors and chronic lung disease.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 2 as a major gene for asthma in children of European farmers

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

The contribution of toll-like receptors to the pathogenesis of asthma

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Lipoprotein I, a TLR2/4 ligand modulates Th2-driven allergic immune responses

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Association of the ASP299GLY TLR4 polymorphism with COPD.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 4 deficiency causes pulmonary emphysema.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors: emerging concepts in kidney disease.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Coactivation of Toll-like receptor-3 and -7 in immune complex glomerulonephritis

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Mammalian toll-like receptors: from endogenous ligands to tissue regeneration.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4.

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

No Association of TLR2 and TLR4 Polymorphisms with Type I Diabetes Mellitus in the Basque Population

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Toll-like receptor 4 (TLR4) gene polymorphisms in celiac disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Sequence Variants of Toll-Like Receptor 4 and Susceptibility to Prostate Cancer

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Local Overexpression of Toll-Like Receptors at the Vessel Wall Induces Atherosclerotic Lesion Formation

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Increased Mucosal Expression of Toll-like Receptor (TLR)2 and TLR4 in Coeliac Disease

1 reference

https://api.crossref.org/works/10.1080%2F08830180801959072

21 January 2018

Identifiers

10.1080/08830180801959072

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

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