(Q37199648)

18 August 2017

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title

The role of regulatory T cells in multiple sclerosis (English)

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18 August 2017

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2

Heinz Wiendl

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18 August 2017

Alla L Zozulya

1

1 reference

18 August 2017

24 June 2008

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Nature Clinical Practice Neurology

18 August 2017

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18 August 2017

4

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18 August 2017

7

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18 August 2017

384-398

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Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.

18 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

B7H1-Ig fusion protein activates the CD4+ IFN-gamma receptor+ type 1 T regulatory subset through IFN-gamma-secreting Th1 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

Prevention of experimental autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

Brain dendritic cells and macrophages/microglia in central nervous system inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

Initiation of immune responses in brain is promoted by local dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

Cutting Edge: TGF- Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

Multiple sclerosis--the plaque and its pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

1 reference

7 January 2021

Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Avoiding autoimmune disease--T cells know their limits

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Multiple sclerosis: trapped in deadly glue

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Dendritic cell-regulatory T-cell interactions control self-directed immunity

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Regulatory T cells: friend or foe in immunity to infection?

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Role of regulatory T cells and FOXP3 in human diseases.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Is FOXP3 a bona fide marker for human regulatory T cells?

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Role of CD8+ T cells in murine experimental allergic encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Regulatory T cells in the control of autoimmune diabetes: the case of the NOD mouse

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Control of regulatory T cell development by the transcription factor Foxp3

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Specific T regulatory cells display broad suppressive functions against experimental allergic encephalomyelitis upon activation with cognate antigen

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Paralysis of CD4(+)CD25(+) regulatory T cell response in chronic autoimmune encephalomyelitis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

CD25 regulatory T cells determine secondary but not primary remission in EAE: impact on long-term disease progression.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

The inflamed central nervous system drives the activation and rapid proliferation of Foxp3+ regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Estrogen treatment induces a novel population of regulatory cells, which suppresses experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Polyclonal expansion of regulatory T cells interferes with effector cell migration in a model of multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Circulating CD4+CD25+ T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

CD4+CD25+FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Suppressor T cells in human diseases

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Decreased FOXP3 levels in multiple sclerosis patients

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Human regulatory T cells and their role in autoimmune disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Abnormal Tr1 differentiation in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

IL-10 suppressor activity andex vivo Tr1 cell function are impaired in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

HLA-G in the nervous system

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Monocyte-derived HLA-G acts as a strong inhibitor of autologous CD4 T cell activation and is upregulated by interferon-beta in vitro and in vivo: rationale for the therapy of multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Postpartum-activation of multiple sclerosis is associated with down-regulation of tolerogenic HLA-G

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Tolerogenic dendritic cells and the quest for transplant tolerance

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Mouse and human dendritic cell subtypes

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Dendritic Cells Matured With TNF can be Further Activated In Vitro and After Subcutaneous Injection In Vivo Which Converts Their Tolerogenicity Into Immunogenicity

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Experimental autoimmune encephalomyelitis induction in naive mice by dendritic cells presenting a self-peptide

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

The brain as an immune privileged site: dendritic cells of the central nervous system inhibit T cell activation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Type II monocytes modulate T cell-mediated central nervous system autoimmune disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Two subsets of dendritic cells are present in human cerebrospinal fluid.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Dendritic cells in multiple sclerosis lesions: maturation stage, myelin uptake, and interaction with proliferating T cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Circulating dendritic cells subsets and regulatory T-cells at multiple sclerosis relapse: differential short-term changes on corticosteroids therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Impaired maturation and altered regulatory function of plasmacytoid dendritic cells in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Altered maturation of circulating dendritic cells in primary progressive MS patients

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Immunological study of IFNbeta-1a-treated and untreated multiple sclerosis patients: clarifying IFNbeta mechanisms and establishing specific dendritic cell immunotherapy.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

CD30 antigen and multiple sclerosis: CD30, an important costimulatory molecule and marker of a regulatory subpopulation of dendritic cells, is involved in the maintenance of the physiological balance between TH1/TH2 immune responses and tolerance. T

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Taking dendritic cells into medicine

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Interferon beta-1a therapy enhances CD4+ regulatory T-cell function: an ex vivo and in vitro longitudinal study in relapsing-remitting multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+regulatory T-cell function and FOXP3 expression

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Dendritic cells and the control of immunity

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Dendritic cells: a conductor of T cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Molecular characterization of allospecific T suppressor and tolerogenic dendritic cells: review

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Virus-stimulated plasmacytoid dendritic cells induce CD4+ cytotoxic regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0832

7 January 2021

Identifiers

DOI

10.1038/NCPNEURO0832

1 reference

18 August 2017

1 reference

PubMed ID

18578001