(Q37212761)

19 August 2017

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title

Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in alpha-1-antitrypsin deficiency (English)

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19 August 2017

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D H Perlmutter

1

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19 August 2017

publication date

11 July 2008

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Cell Death & Differentiation

19 August 2017

published in

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19 August 2017

volume

16

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19 August 2017

issue

1

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19 August 2017

page(s)

39-45

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https://scigraph.springernature.com/pub.10.1038/cdd.2008.103

19 August 2017

exact match

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cites work

An overview of the serpin superfamily

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.103

Pathogenesis of chronic liver injury and hepatocellular carcinoma in alpha-1-antitrypsin deficiency

21 January 2018

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The cellular response to aggregated proteins associated with human disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.103

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.103

Smoking, lung function, and alpha 1-antitrypsin deficiency.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.103

Accumulation of PiZ alpha 1-antitrypsin causes liver damage in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Alpha1-antitrypsin deficiency in 26-year-old subjects: lung, liver, and protease/protease inhibitor studies

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.103

A lag in intracellular degradation of mutant alpha 1-antitrypsin correlates with the liver disease phenotype in homozygous PiZZ alpha 1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Uncoupling proteasome peptidase and ATPase activities results in cytosolic release of an ER polytopic protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Organizational diversity among distinct glycoprotein endoplasmic reticulum-associated degradation programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Mutant fibrinogen cleared from the endoplasmic reticulum via endoplasmic reticulum-associated protein degradation and autophagy: an explanation for liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.103

Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.103

Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.103

Regulator of G Signaling 16 is a marker for the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.103

An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2008.103

The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Feeding and fasting controls liver expression of a regulator of G protein signaling (Rgs16) in periportal hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Analyses of hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Alpha-1-antitrypsin deficiency: a new paradigm for hepatocellular carcinoma in genetic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Quantitative isolation of alphalAT mutant Z protein polymers from human and mouse livers and the effect of heat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Alpha-1-antitrypsin mutant Z protein content in individual hepatocytes correlates with cell death in a mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

7 January 2021

PULMONARY EMPHYSEMA AND ALPHA1-ANTITRYPSIN DEFICIENCY.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

7 January 2021

Risk of cirrhosis and primary liver cancer in alpha 1-antitrypsin deficiency

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

7 January 2021

Neonatal hepatitis induced by alpha 1-antitrypsin: a transgenic mouse model

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

7 January 2021

Liver Disease in Alpha1-Antitrypsin Deficiency Detected by Screening of 200,000 Infants

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

7 January 2021

Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

7 January 2021

Processing by endoplasmic reticulum mannosidases partitions a secretion-impaired glycoprotein into distinct disposal pathways

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

7 January 2021

Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

7 January 2021

The core domain of RGS16 retains G-protein binding and GAP activity in vitro, but is not functional in vivo

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

7 January 2021

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2008.103

7 January 2021

Identifiers

DOI

10.1038/CDD.2008.103

1 reference

Dimensions Publication ID

19 August 2017

1002606419

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