(Q37215386)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

main subject

disease-related genes

1 reference

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

author name string

Leni S Jacob

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Xiaofeng Wu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Michael E Dodge

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Chih-Wei Fan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Ozlem Kulak

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Baozhi Chen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Baolin Wang

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

James F Amatruda

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Lawrence Lum

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

publication date

25 January 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

issue

157

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

page(s)

ra4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

20 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3790583/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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1 reference

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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction

6 September 2017

1 reference

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Dishevelled: The hub of Wnt signaling

6 September 2017

1 reference

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Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Towards an integrated view of Wnt signaling in development

6 September 2017

1 reference

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Wnt/beta-catenin signaling: components, mechanisms, and diseases

6 September 2017

1 reference

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Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis.

6 September 2017

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Somatic LKB1 mutations promote cervical cancer progression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Ciliary dysfunction in developmental abnormalities and diseases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

6 September 2017

1 reference

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Hedgehog signaling in development and cancer.

6 September 2017

1 reference

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LKB1; linking cell structure and tumor suppression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

The intraflagellar transport protein IFT57 is required for cilia maintenance and regulates IFT-particle-kinesin-II dissociation in vertebrate photoreceptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

6 September 2017

1 reference

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Patched1 regulates hedgehog signaling at the primary cilium

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Dynamic recruitment of axin by Dishevelled protein assemblies

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

HEF1-dependent Aurora A activation induces disassembly of the primary cilium

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

The graded response to Sonic Hedgehog depends on cilia architecture

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Mining the Wnt pathway for cancer therapeutics

6 September 2017

1 reference

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Histone deacetylase inhibitors: gathering pace

6 September 2017

1 reference

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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Vertebrate Smoothened functions at the primary cilium

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

6 September 2017

Wnt/beta-catenin pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

6 September 2017

1 reference

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Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

No tail co-operates with non-canonical Wnt signaling to regulate posterior body morphogenesis in zebrafish

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Deconstructing the hedgehog pathway in development and disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Experimental model for studying the primary cilia in tissue culture cells

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3790583

Targeting the Hedgehog pathway in cancer

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21266715

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCISIGNAL.2001225

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21266715%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference