(Q37232979)

English

TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway

scientific article published on 24 March 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

apoptotic process

0 references

pancreatic cancer

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Fazlul H. Sarkar

6

object named as

Fazlul H Sarkar

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

author name string

Zhiwei Wang

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Asfar Sohail Azmi

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Aamir Ahmad

3

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Sanjeev Banerjee

4

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Shaomeng Wang

5

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Ramzi M Mohammad

7

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

language of work or name

0 references

publication date

24 March 2009

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Cancer Research

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

69

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

7

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

2757-2765

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

6 September 2017

TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and invasion in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

6 September 2017

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

6 September 2017

BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

6 September 2017

Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

6 September 2017

Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-kappaB, p53, bax, and p27 levels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

6 September 2017

Cancer statistics, 2008

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

6 September 2017

Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

6 September 2017

Down-regulation of Forkhead Box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

6 September 2017

Notch signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

6 September 2017

Mechanisms of cytochrome c release by proapoptotic BCL-2 family members

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

6 September 2017

The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

14 September 2017

Downregulation of BCL-2 induces downregulation of carbonic anhydrase IX, vascular endothelial growth factor, and pAkt and induces radiation sensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

14 September 2017

BCL-2 functions as an activator of the AKT signaling pathway in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

14 September 2017

Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

14 September 2017

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

14 September 2017

Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

14 September 2017

NOTCH and PI3K-AKT pathways intertwined.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

3 September 2018

Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

3 September 2018

Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

3 September 2018

Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

3 September 2018

Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798007

3 September 2018

Off the beaten pathway: the complex cross talk between Notch and NF-kappaB

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial cells expressing Bcl-2 promotes tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IKK beta is required for Bcl-2-mediated NF-kappa B activation in ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of IP3-mediated calcium release and apoptosis by Bcl-2 involves the participation of protein phosphatase 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 Orchestrates a Cross-talk between Endothelial and Tumor Cells that Promotes Tumor Growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABT-737, proving to be a great tool even before it is proven in the clinic

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318573

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-08-3060

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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