(Q37237331)

19 August 2017

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title

Investigating human leukemogenesis: from cell lines to in vivo models of human leukemia (English)

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19 August 2017

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J A Kennedy

1

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19 August 2017

F Barabé

series ordinal

2

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19 August 2017

language of work or name

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7 August 2008

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19 August 2017

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19 August 2017

volume

22

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19 August 2017

issue

11

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19 August 2017

page(s)

2029-2040

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https://scigraph.springernature.com/pub.10.1038/leu.2008.206

19 August 2017

exact match

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cites work

Prognostic significance of T-lineage leukemic cell growth in SCID mice: a Children's Cancer Group study

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Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells

21 January 2018

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Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.206

Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice

21 January 2018

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Cancer genes and the pathways they control

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Concepts of human leukemic development.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Origins of chromosome translocations in childhood leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Further evidence for a non-random chromosomal abnormality in acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

The impact of translocations and gene fusions on cancer causation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

FLT3 and acute myelogenous leukemia: biology, clinical significance and therapeutic applications

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

CYTOLOGY OF BURKITT'S TUMOUR (AFRICAN LYMPHOMA)

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Continuous hematopoietic cell lines as model systems for leukemia-lymphoma research

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Nutritional requirements of human leukemic cells. Asparagine requirements and the effect of L-asparaginase

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Il-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Ba/F3 cells and their use in kinase drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Leukemia-lymphoma cell lines as model systems for hematopoietic research

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Establishment of an inducible expression system of chimeric MLL-LTG9 protein and inhibition of Hox a7, Hox b7 and Hox c9 expression by MLL-LTG9 in 32Dcl3 cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Modeling the initiation and progression of human acute leukemia in mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Modelling haematopoietic malignancies in the mouse and therapeutical implications

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Acute leukaemia in bcr/abl transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Transgenics at breaking-point

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

The invertor knock-in conditional chromosomal translocation mimic

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Modeling the dosage effect of oncogenes in leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

STAT5 signaling is required for the efficient induction and maintenance of CML in mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Cancer in rodents: does it tell us about cancer in humans?

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Species- and cell type-specific requirements for cellular transformation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Genetic background and the dilemma of translating mouse studies to humans

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Mutant N-ras preferentially drives human CD34+ hematopoietic progenitor cells into myeloid differentiation and proliferation both in vitro and in the NOD/SCID mouse

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Modulation of p210(BCR-ABL) activity in transduced primary human hematopoietic cells controls lineage programming

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

NUP98-HOXA9 induces long-term proliferation and blocks differentiation of primary human CD34+ hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBPalpha.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Engraftment of immune-deficient mice with human hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Development of a human adaptive immune system in cord blood cell-transplanted mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

A model of human acute lymphoblastic leukemia in immune-deficient SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Human AML cells in NOD/SCID mice: engraftment potential and gene expression

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Targeting of CD44 eradicates human acute myeloid leukemic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Tumor growth need not be driven by rare cancer stem cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Comment on "Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells"

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

BCR-ABL-transduced human cord blood cells produce abnormal populations in immunodeficient mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

JAK-2 mutations and their relevance to myeloproliferative disease

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Leukemia in twins: lessons in natural history

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Distinct classes of human stem cells that differ in proliferative and self-renewal potential

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Humanized mice in translational biomedical research

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Human-Hemato-Lymphoid-System Mice: Opportunities and Challenges

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Nonexpanded primary lung and bone marrow–derived mesenchymal cells promote the engraftment of umbilical cord blood–derived CD34+ cells in NOD/SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Effect of mesenchymal stem cell transplantation on the engraftment of human hematopoietic stem cells and leukemic cells in mice model.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.206

7 January 2021

Identifiers

DOI

10.1038/LEU.2008.206

1 reference

19 August 2017

1 reference