(Q37244563)

19 August 2017

Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B. (English)

1 reference

19 August 2017

0 references

Eleftheria Maratos-Flier

series ordinal

2

object named as

Eleftheria Maratos-Flier

1 reference

19 August 2017

3

Jeffrey S Flier

1 reference

19 August 2017

Ren Zhang

1

1 reference

PMCID

2703511

19 August 2017

language of work or name

English

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publication date

9 April 2009

1 reference

19 August 2017

7

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inferred from page(s)

published in

Endocrinology

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19 August 2017

150

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19 August 2017

7

1 reference

19 August 2017

3076-3082

1 reference

PMCID

2703511

describes a project that uses

19 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2703511/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts

6 September 2017

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Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).

6 September 2017

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Inflammation and insulin resistance

6 September 2017

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Effects of etanercept in patients with the metabolic syndrome

6 September 2017

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Keynote review: phosphodiesterase-4 as a therapeutic target

6 September 2017

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Inflammation, stress, and diabetes

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6 September 2017

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Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes

6 September 2017

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Obesity wars: molecular progress confronts an expanding epidemic

6 September 2017

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Inflammation: the link between insulin resistance, obesity and diabetes

6 September 2017

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

6 September 2017

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Obesity is associated with macrophage accumulation in adipose tissue

6 September 2017

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Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

6 September 2017

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PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

6 September 2017

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Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses

6 September 2017

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Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ.

6 September 2017

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The next generation of PDE4 inhibitors

6 September 2017

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The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation.

6 September 2017

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Obesity and the regulation of energy balance

6 September 2017

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Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain

6 September 2017

1 reference

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Molecular regulation of adipogenesis

6 September 2017

1 reference

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Adipose tissue as an endocrine organ

6 September 2017

1 reference

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Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes

6 September 2017

1 reference

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Central nervous system control of food intake

6 September 2017

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Genetics of body-weight regulation

6 September 2017

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Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here?

6 September 2017

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Annual Deaths Attributable to Obesity in the United States

6 September 2017

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Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice

6 September 2017

1 reference

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The molecular biology of cyclic nucleotide phosphodiesterases.

6 September 2017

1 reference

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Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect

6 September 2017

1 reference

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C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?

6 September 2017

1 reference

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Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity

6 September 2017

1 reference

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Leptin and the regulation of body weight in mammals

6 September 2017

1 reference

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Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.

6 September 2017

1 reference

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Positional cloning of the mouse obese gene and its human homologue

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

The adipocyte: storage depot or node on the energy information superhighway?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

A novel serum protein similar to C1q, produced exclusively in adipocytes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Tumor necrosis factor alpha: a key component of the obesity-diabetes link

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Elaboration of type-1 plasminogen activator inhibitor from adipocytes. A potential pathogenetic link between obesity and cardiovascular disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Identification of two splice variant forms of type-IVB cyclic AMP phosphodiesterase, DPD (rPDE-IVB1) and PDE-4 (rPDE-IVB2) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

mRNA expression and antilipolytic role of phosphodiesterase 4 in rat adipocytes in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

AdipoQ is a novel adipose-specific gene dysregulated in obesity

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Augmentation of lipolysis in adipocytes from fed rats, but not from starved rats, by inhibition of rolipram-sensitive phosphodiesterase 4.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

The obesity epidemic is a worldwide phenomenon

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Characterization of the rolipram-sensitive, cyclic AMP-specific phosphodiesterases: identification and differential expression of immunologically distinct forms in the rat brain

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2703511

As obesity rates rise, experts struggle to explain why

4 December 2018

1 reference

12 December 2020

Adipose tissue as an endocrine and paracrine organ

1 reference

12 December 2020

METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS

1 reference

12 December 2020

No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients

1 reference

12 December 2020

cAMP-dependent protein kinase and lipolysis in rat adipocytes. I. Cell preparation, manipulation, and predictability in behavior

1 reference

12 December 2020

Identifiers

DOI

10.1210/EN.2009-0108

1 reference

19 August 2017

1 reference

19 August 2017

1 reference

PMCID

2703511