(Q37254347)

19 August 2017

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title

Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators? (English)

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19 August 2017

main subject

ascending cholangitis

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sclerosing cholangitis

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primary sclerosing cholangitis

inferred from title

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Ulrich Beuers

1

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19 August 2017

Gerd A Kullak-Ublick

2

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19 August 2017

Thomas Pusl

3

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19 August 2017

Erik R Rauws

4

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19 August 2017

Christian Rust

5

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19 August 2017

publication date

1 February 2009

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Clinical Reviews in Allergy & Immunology

19 August 2017

published in

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19 August 2017

volume

36

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19 August 2017

issue

1

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19 August 2017

page(s)

52-61

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https://scigraph.springernature.com/pub.10.1007/s12016-008-8085-y

19 August 2017

exact match

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cites work

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12 December 2020

Peroxisome proliferator-activated receptors: nuclear control of metabolism

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12 December 2020

Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer

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12 December 2020

Immunopathogenesis of primary sclerosing cholangitis

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12 December 2020

CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice

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12 December 2020

Fenofibrate for patients with asymptomatic primary biliary cirrhosis

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12 December 2020

Ursodeoxycholic acid therapy and the risk of colorectal adenoma in patients with primary biliary cirrhosis: an observational study

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12 December 2020

Oral budesonide and ursodeoxycholic acid for treatment of primary biliary cirrhosis: results of a prospective double-blind trial

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12 December 2020

Primary sclerosing cholangitis and ulcerative colitis: Evidence for increased neoplastic potential

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12 December 2020

Hepatic and extrahepatic malignancies in primary sclerosing cholangitis

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12 December 2020

Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis

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12 December 2020

Induction of ABCC3 (MRP3) by pregnane X receptor activators

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12 December 2020

Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor

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12 December 2020

Identification of a nuclear receptor for bile acids

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12 December 2020

Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression

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12 December 2020

Intestinal bile acid transport: biology, physiology, and pathophysiology

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12 December 2020

The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

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12 December 2020

Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene

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12 December 2020

Hepatic levels of bile acids in end-stage chronic cholestatic liver disease

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12 December 2020

Bile acid-induced negative feedback regulation of the human ileal bile acid transporter

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12 December 2020

Effects of budesonide on P-glycoprotein expression in intestinal cell lines

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12 December 2020

Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis

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12 December 2020

Biliary secretion of bile acids and lipids in primary sclerosing cholangitis. Influence of cholestasis and effect of ursodeoxycholic acid treatment

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12 December 2020

24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

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12 December 2020

The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells

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12 December 2020

Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro

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12 December 2020

Etiopathogenesis of primary sclerosing cholangitis

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12 December 2020

Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids

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12 December 2020

Medical treatment of cholestatic liver disease

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12 December 2020

An essential role of the CAAT/enhancer binding protein-alpha in the vitamin D-induced expression of the human steroid/bile acid-sulfotransferase (SULT2A1).

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12 December 2020

Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: a meta-analysis

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12 December 2020

Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease

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12 December 2020

Proximal colorectal dysplasia or cancer in ulcerative colitis. The impact of primary sclerosing cholangitis and sulfasalazine: results from a 20-year surveillance study

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12 December 2020

Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes

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12 December 2020

Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation

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12 December 2020

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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12 December 2020

Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.

1 reference

12 December 2020

Primary sclerosing cholangitis--the arteriosclerosis of the bile duct?

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12 December 2020

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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12 December 2020

Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter

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12 December 2020

Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis.

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12 December 2020

New perspectives for the treatment of cholestasis: lessons from basic science applied clinically

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12 December 2020

Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice

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12 December 2020

Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited

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12 December 2020

A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis

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12 December 2020

Prospective randomized crossover trial of combination therapy with bezafibrate and UDCA for primary biliary cirrhosis.

1 reference

12 December 2020

High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis

1 reference

12 December 2020

Fibrate for treatment of primary biliary cirrhosis

1 reference

12 December 2020

Risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis following orthotopic liver transplantation.

1 reference

12 December 2020

Molecular pathogenesis of cholestasis.

1 reference

12 December 2020

Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

1 reference

12 December 2020

Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis: a three-year randomized trial

1 reference

12 December 2020

Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations.

1 reference

12 December 2020

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

1 reference

12 December 2020

Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'.

1 reference

12 December 2020

Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) Gene Transcription by Rifampicin: Roles of Hepatocyte Nuclear Factor 4 and Pregnane X Receptor

1 reference

12 December 2020

Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms

1 reference

12 December 2020

PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition.

1 reference

12 December 2020

Bile acids: natural ligands for an orphan nuclear receptor

1 reference

12 December 2020

Novel biotransformation and physiological properties of norursodeoxycholic acid in humans.

1 reference

12 December 2020

No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis

1 reference

12 December 2020

Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamic action of budesonide in early- and late-stage primary biliary cirrhosis

1 reference

12 December 2020

Vitamin D receptor as an intestinal bile acid sensor

1 reference

12 December 2020

Ursodiol for primary sclerosing cholangitis. Mayo Primary Sclerosing Cholangitis-Ursodeoxycholic Acid Study Group

1 reference

12 December 2020

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

1 reference

12 December 2020

PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis

1 reference

12 December 2020

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

1 reference

12 December 2020

Medical management of mild to moderate Crohn's disease: evidence-based treatment algorithms for induction and maintenance of remission

1 reference

12 December 2020

High-dose ursodeoxycholic acid in primary sclerosing cholangitis: a 5-year multicenter, randomized, controlled study

1 reference

12 December 2020

Long-Term Effect of Corticosteroid Treatment in Primary Sclerosing Cholangitis Patients

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12 December 2020

Budesonide in previously untreated autoimmune hepatitis.

1 reference

12 December 2020

Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis. A 3-year pilot study with a placebo-controlled study period

1 reference

12 December 2020

Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid

1 reference

12 December 2020

Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis

1 reference

12 December 2020

A preliminary trial of high-dose ursodeoxycholic acid in primary sclerosing cholangitis

1 reference

12 December 2020

FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

1 reference

12 December 2020

Liver transplantation for sclerosing cholangitis

1 reference

12 December 2020

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

1 reference

12 December 2020

Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis

1 reference

12 December 2020

Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis

1 reference

12 December 2020

Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury

1 reference

12 December 2020

Liver transplantation for primary sclerosing cholangitis; predictors and consequences of hepatobiliary malignancy

1 reference

12 December 2020

Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: a placebo-controlled trial

1 reference

12 December 2020

The expanding role of the bile acid receptor FXR in the small intestine

1 reference

12 December 2020

Ursodeoxycholic acid in cholestasis: potential mechanisms of action and therapeutic applications

1 reference

12 December 2020

Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor

1 reference

12 December 2020

Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor

1 reference

12 December 2020

Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans

1 reference

12 December 2020

Benefit of farnesoid X receptor inhibition in obstructive cholestasis

1 reference

12 December 2020

1alpha,25(OH)2D3-induced DNA methylation suppresses the human CYP27B1 gene

1 reference

12 December 2020

Primary sclerosing cholangitis: summary of a workshop

1 reference

12 December 2020

Oral budesonide in the treatment of primary sclerosing cholangitis

1 reference

12 December 2020

Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis.

1 reference

12 December 2020

The medical management of primary sclerosing cholangitis

1 reference

12 December 2020

The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechan

1 reference

12 December 2020

Rifampin is safe for treatment of pruritus due to chronic cholestasis: a meta-analysis of prospective randomized-controlled trials

1 reference

12 December 2020

Th1 cytokine-induced downregulation of PPARgamma in human biliary cells relates to cholangitis in primary biliary cirrhosis

1 reference

12 December 2020

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

1 reference

12 December 2020

Budesonide or prednisone in combination with ursodeoxycholic acid in primary sclerosing cholangitis: a randomized double-blind pilot study. Belgian-Dutch PSC Study Group

1 reference

12 December 2020

Colorectal cancer in patients with inflammatory bowel disease after liver transplantation for primary sclerosing cholangitis

1 reference

12 December 2020

Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

1 reference

12 December 2020

1alpha,25-dihydroxyvitamin D3 downregulates CYP27B1 and induces CYP24A1 in colon cells.

1 reference

12 December 2020

Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene

1 reference

12 December 2020

The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: differential effect on apoptosis in the presence of a colon carcinogen

1 reference

12 December 2020

10.1007/S12016-008-8085-Y

Identifiers

DOI

1 reference

19 August 2017

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