(Q37256627)

English

The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors

scientific article published on 29 May 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Lyle D. Burgoon

object named as

Lyle D Burgoon

2

0 references

author name string

Jennifer M Phillips

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Jay I Goodman

3

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

publication date

29 May 2009

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Toxicological Sciences

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

110

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

319-333

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708600

6 September 2017

Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708600

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Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis

1 reference

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Advances in chemical carcinogenesis: a historical review and prospective

1 reference

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6 September 2017

The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription

1 reference

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Epigenetic changes in cancer

1 reference

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Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

1 reference

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Epigenetic gene silencing in cancer: the DNA hypermethylome

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Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

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Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data

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Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences.

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Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice

1 reference

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Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

1 reference

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6 September 2017

Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital

1 reference

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6 September 2017

DAVID: Database for Annotation, Visualization, and Integrated Discovery

1 reference

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6 September 2017

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

1 reference

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Cancer. Addiction to oncogenes--the Achilles heal of cancer

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6 September 2017

Altered DNA methylation: a secondary mechanism involved in carcinogenesis

1 reference

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6 September 2017

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

1 reference

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6 September 2017

Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis

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The Hallmarks of Cancer

1 reference

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6 September 2017

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2708600

6 September 2017

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

1 reference

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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

1 reference

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Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion

1 reference

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Characterization of a cDNA clone for mouse phenobarbital-inducible cytochrome P-450b

1 reference

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Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis

1 reference

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PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor

1 reference

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Alterations in DNA methylation may play a variety of roles in carcinogenesis

1 reference

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Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats

1 reference

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Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis

1 reference

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Glucocorticoid and sex hormones as activating or modulating factors for expression of Cyp2b-9 and Cyp2b-10 in the mouse liver and hepatocytes

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Identification of genes that may play critical roles in phenobarbital (PB)-induced liver tumorigenesis due to altered DNA methylation

1 reference

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A gene expression biomarker provides early prediction and mechanistic assessment of hepatic tumor induction by nongenotoxic chemicals

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Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis.

1 reference

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Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

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The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

1 reference

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Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter

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Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor

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1 reference

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Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration.

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Inflaming metastasis

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19482888

12 December 2020

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inferred from PubMed ID database lookup

Phenobarbital induces progressive patterns of GC-rich and gene-specific altered DNA methylation in the liver of tumor-prone B6C3F1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19482888

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/TOXSCI/KFP108

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

ResearchGate publication ID

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